DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FANCI and AT5G49110

DIOPT Version :9

Sequence 1:	NP_610429.2	Gene:	FANCI / 35895	FlyBaseID:	FBgn0033354	Length:	1481	Species:	Drosophila melanogaster
Sequence 2:	NP_001119400.1	Gene:	AT5G49110 / 834970	AraportID:	AT5G49110	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1557	Identity:	300/1557 - (19%)
Similarity:	569/1557 - (36%)	Gaps:	399/1557 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LSSTELSYKQTFDLITRLSQDLATFPSEQLAWI---------VEHCMDGIRQGDAKCVGWK---- 122
            |:|..:||.|.|: ..::..|..:..:.||...         |:..:|.|..|..:.:...
plant    89 LASLLISYTQIFN-SCKIPSDSDSLKTIQLFGTLLRYLHVKEVKSVVDSILSGVTRVITVDEAQV 152

  Fly   123 -DLLPDALSLLLARPRFLLNGISIDGMEFRDTTVRSIATMQWPASILTPIADMFKTMN-LSSGEI 185
             ||||....||....:       ...::|.::.:..:.:.:|..::||.:..:.|..: |..|..
plant   153 FDLLPVCFDLLRREGK-------ASEIDFVNSAIDRVLSCEWNKALLTKMVSLAKEFSFLDKGRK 210

  Fly   186 VTVLNKFSGALQELSPMELPALCFQLFSMCSTASQLIIPLLALEKYFHRNYYKRLFSDMCSNSTN 250
            ..::.|....::.:...:||:|.:||..:.|                         ...|.....
plant   211 SELVEKVFVGIKLIDLQDLPSLVYQLLVLAS-------------------------KGFCKREVI 250

  Fly   251 LDSIDLFSDKE-------LREAEETILHHLNYCTMY--KLTEKHLAIM---LRNFLHMPDVILTP 303
            ...:..|..|.       :|:.|.|:|.|:|:....  .|.::.:|::   ||.|.|
plant   251 GGVVGYFGSKAETRVASVVRQIEGTVLLHVNFAVKQDPSLGQEVVALVKSDLRAFNH-------- 307

  Fly   304 FMLSAIISMTSINRDPESARISHSILLPFLRNVIKNNEEERTLADYSVWY------RDTLQRKQV 362
            |.::.:.|:..:.:..||:       |..||..:.....:..|:....|.      ...|..|.|
plant   308 FTVAVLFSVARVRKFGESS-------LGMLRTALLTAYNDYRLSKDCKWLPVELKEESFLHAKLV 365

  Fly   363 DLQQVLTVLIDQNKDGKDVITPGLVHLVFYLLKS------------------QSPKMHTLAITFL 409
              ::.|...:.:.:.|::.:.|.::...|.||:|                  :...:..|...|.
plant   366 --EKSLLRAVSECRYGREHVVPSVIQFGFMLLESVEEGRSNEFGDSKGVLGIEKLSIQILGTLFE 428

  Fly   410 TKFIRKRFIFGQGIIKLISEWMIVYQEQNQFSECLTLLSVADTYTVSECMKPIQSVLEHMQWLSG 474
            ...:.:..|..|...:::|   :...:.......|..|....:..:.|.:..::.:|::..::.|
plant   429 VHDMTRNEIIEQCKFRILS---LKCAKSKPIVRLLGYLVQRYSLIMLEFVHHLKELLDYFTFMEG 490

  Fly   475 EQSMRMMNFILPLLKISNRVRDALIDVLCKAMSSSGIQKRRMAIYGFCMILKQLNNSNAVRQTSS 539
            ..|..:::.::||:|.|..::|..|.|:.|||    .::..........::..|..:..:.:..|
plant   491 HISCFLVSAVIPLIKFSRDLQDYTILVIRKAM----FRREDTVRVAATKVITDLILAEKLAKRDS 551

  Fly   540 ATSFCTQHSISGYSIMTQNTLGSRSNPQRNFDMLTLEIIGMLRNCLQQQFDIRCSLYENLQRAVE 604
            :.:|....|.:..|..|:.:...|.|       |..|:.|:|:.||.||..::..:|:.|.:.|.
plant   552 SFTFQDSASQASSSQQTEMSCIVRGN-------LFTELNGLLQRCLYQQARVKEVVYDGLVKLVL 609

  Fly   605 LNAKLVPHVLQVIDWHFRSFFDTPSAEDAGDDLDTVFRIRYDQLVSSSDDQHMEIQLKDNLGKLI 669
            ::.....|||..:..||..||        |.|.|  |::.....:....|   :..:::.|.:|:
plant   610 IDPSSGGHVLDFLMPHFLRFF--------GQDTD--FQLGITSCIRVEGD---KFTIEEPLDRLL 661

  Fly   670 QFVANCLAV-----FDRAPS-------GYDTREMNRLMSFCVDRMVANRLPLEEITPPATHLKCA 722
            ..|:..|.:     .|| ||       |:...:.|       ::.|...|..|..:.....::..
plant   662 FCVSWILLLQQQNSSDR-PSDAAWPCFGFSLSQDN-------EQQVGRNLSHEAYSSALVKIRSF 718

  Fly   723 LVLQQLN------------------------IIEGIICHLL------LKSKPQ---NNAVCQILP 754
            |:.::|.                        ||.||:..||      |:.:|:   .:...:|:.
plant   719 LLGKKLGDIVGQSQDTVSASLEEDKRKSYCLIILGIVQVLLNYIIVDLEKQPEGKKGSVRKEIVD 783

  Fly   755 LFNQHCKLLESLKALSDASKKAH--KQLKQTAKNNSTSTCNLTLNGVPVKTMCTQPDNIWDLAIL 817
            |.:    |.|||:.....||:::  |:::.:|.|: |...|.::|....|.......:|:.|.:|
plant   784 LID----LYESLEKDVGKSKQSNVGKRVRFSACND-TDLGNTSINEEREKVPFLATSSIYQLFLL 843

  Fly   818 DKLL--------------HLLLDDVVAFAAPEKTVLLRSNEPLVRYVLSVTASRV-------ESI 861
            ...|              |       :.::|.||     .:.:..:.|.|....:       |..
plant   844 SFKLYSSKSVGTQSGSQDH-------SHSSPAKT-----EKSIFSFTLHVCVGHINSSLCMKEEN 896

  Fly   862 RLEP----DYKQLAYSKRTFKQLTDITKVIY--------------------------ERCIQ--- 893
            .|:|    |.|.|.         ..:.||:|                          ::|:.
plant   897 PLKPLVCGDMKVLG---------PPLLKVVYLLKPEPPLATGQTNKEKKGRKDVDGRKQCLHLAL 952

  Fly   894 -RLPELWKNFDMQSA------------ALATQCFSECLKTAHETYSKKFED-FVKSFDLASIKGS 944
             .|.||...:...|.            |.......||.:      :.|.|| .:||.::...|
plant   953 LSLKELLNIYSSGSGLTGLLEDLLAVPASEDATLEECRE------ASKIEDPLIKSIEIFMAK-- 1009

  Fly   945 RNKEVVYTIQDVLDDFMTEYGTDDSICKNEFVSKLPVYLLESLEILLDHIDYQDRAATESYTWLL 1009
                   .::.::.||:.:...|....|. .:....|.:|..:.:.|.: :..|:......:|..
plant  1010 -------IMKPMITDFIAQNSNDVEEAKT-IIFNCTVQILCDIMLKLGN-NLPDKFKQRHGSWAH 1065

  Fly  1010 NFCSKNEILNSEMGLVHRMLFVQRQKTHLGPFFDS----------VARQLGHVLGVQNEDA--PS 1062
            ..|...|..|:.         |.:....|...|.:          ||::|.:::|:...|.  .|
plant  1066 QICRSCETSNTT---------VAKSVLKLAISFTTSPGDLCIAVEVAQELQNIMGLDKSDTLEVS 1121

  Fly  1063 ESVELTLKSISTVTIESC-LQHLYAAIQKQLNDVDYFVTKANNLNYKCQVVPEIDQIYWRGNLDS 1126
            ||. :.:...::.::.|| ||.:.:||.    |:|:...|..|.....|     ..|:...:.:|
plant  1122 ESY-MVINQSTSASVTSCILQSIDSAIV----DMDWATKKLKNFYVVSQ-----KNIHLSDDTES 1176

  Fly  1127 MDRSICTQIIH--ISRTLLVLTNVCIPLGSLMDG----LMKLLIQHYTCLKSLTKHYISSYTSDT 1185
            ...|:..:.::  ...|:.:|::  ..|.:|.:.    .::|.::.|..|..:.|..|:.....
plant  1177 TVGSVLEEALYSMAESTVRILSS--FVLMNLKESQAAQFLRLAVRFYKQLAQIVKLRIAPKGCK- 1238

  Fly  1186 SIENIKSTKFELLLRAVGKQLPANIYELITYIE-------ANTL------------------DEE 1225
              :.:.|.||:.|:....|.|...:|..::.::       ..||                  .:|
plant  1239 --QILPSLKFQKLVELTCKSLTVPLYPFLSEMQKVKVVQAVITLMFLRIQKREVLLLFQIQEQQE 1301

  Fly  1226 AQQHTKKRKVQAERAKVLRETRLIPKVIMVIEDFNKHIILLSKKTKSKNRLTDYLHLGTMRDFD- 1289
            :..|..|..:.    |:.:|.:.||.:|..|||..:::|.|||.||.  .|..:....|.|||.
plant  1302 SVSHNSKGIIN----KIKQENKCIPDLIFQIEDCERYLIQLSKVTKL--NLLRHAKRSTARDFKI 1360

  Fly  1290 IKSTDLRAAIERSISDGRNISTEDSNAEDRDEDEDENENVEEDDDAQSTTYPEDLEEKEDECLVI 1354
            |:.:|..|..|    ||.|         ..:|.|.:|.|:.||          ||.::.|:
plant  1361 IEDSDPPAGGE----DGGN---------QEEETETQNNNIGED----------DLRQESDD---- 1398

  Fly  1355 EKKEERRRRRAPSSEAEDPQPKRKRGRKAAEQLEAEDEEQVEEEQPETTLKLRRNKKVEPKT 1416
            :..||....|..||.:   .|.....:..|...|.:|||:.|:::.|......|.||:..|:
plant  1399 DGSEEMLSPRNASSVS---SPGLDSDKTIAAATEEDDEEEQEQDEGEEESGDNRPKKMARKS 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FANCI	NP_610429.2	FANCI	37..1293	CDD:212594	268/1432 (19%)
AT5G49110	NP_001119400.1	FANCI	67..1363	CDD:212594	268/1431 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4553
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I1966
OMA	1	1.010	-	-		QHG60155
OrthoDB	1	1.010	-	-		D169407at2759
OrthoFinder	1	1.000	-	-		FOG0006301
OrthoInspector	1	1.000	-	-		oto3823
orthoMCL	1	0.900	-	-		OOG6_104620
Panther	1	1.100	-	-	LDO	PTHR21818
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5252
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840