DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FANCI and fanci

DIOPT Version :9

Sequence 1:	NP_610429.2	Gene:	FANCI / 35895	FlyBaseID:	FBgn0033354	Length:	1481	Species:	Drosophila melanogaster
Sequence 2:	XP_021326126.1	Gene:	fanci / 324185	ZFINID:	ZDB-GENE-030131-2905	Length:	1376	Species:	Danio rerio

Alignment Length:	1506	Identity:	336/1506 - (22%)
Similarity:	594/1506 - (39%)	Gaps:	303/1506 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DELELLIQNTPIEKLKETLKSTMTRSEGITYWNYLLRGFNPESKDALAKR-----FECVRSFMDG 70
            |:|..::.|:.: |.|:|         ||.. ..:.:| :|.|....|.|     ..|:.....|
Zfish    33 DQLTTMLTNSAL-KGKDT---------GILI-KAIFKG-SPVSVSHGANRRLLVYKHCIPLCESG 85

  Fly    71 LSSTELSYKQTFDLITRLSQDLATFPSEQLAWIVEHCMDGIRQGDAKCVGWKDLLPDALSLLLAR 135
            ...||::    .|:|..|..|..:.|...||.:....:|.|:.|:.......:|.|..|:.|.|.
Zfish    86 DLQTEVA----SDIIGLLMLDTHSLPGPALATLASLYVDAIKVGEMNSGRSLELFPTILTALSAT 146

  Fly   136 PRFLLNGISIDGMEFRDTTVRSIATMQWPASILTPIADMFKTMNLSSGEIVTVLNKFSGALQELS 200
            .........:.|.|::...:.|:.:.:|....:..:..||:.:.||:.|:..::.|......:|.
Zfish   147 DALAYGKGELTGNEYKKQLINSLCSSRWDPQCVIHLTTMFRDVPLSTEELQFLIEKILRMFLKLD 211

  Fly   201 PMELPALCFQLFSMCSTASQLIIPLLALEKYFHRNYYKR---LFSDMCSNSTNLD-SIDLFSDKE 261
            ..|:|.|.:||..:.:...:.::    ||...  ||:|:   |..:...|....| .:......:
Zfish   212 LQEIPPLVYQLLLLSAKGCKKLV----LEGII--NYFKKQDQLQKEEQRNGECEDVEVQTIPQDQ 270

  Fly   262 LREAEETILHHLNYCTMYKLTEKHLAIML-----RNFLHMPDVI----LTPFMLSAIISMTSINR 317
            ||..|.|::.|:.:           ||.|     |.|.....|.    |.||.::.::|:..|.|
Zfish   271 LRHVEGTVILHIVF-----------AIRLDHELGREFFKNLKVAQSDPLCPFSIALLLSVARIQR 324

  Fly   318 DPESARISHSILLPFLRNVIKNNEEERTLADYSVWYRDTLQRKQVDLQQVLTVLIDQNKD---GK 379
            ..|.       :..||:..|..|.::..:.:.|.:.:|.|.:    ...|..:::|..|:   |.
Zfish   325 YEEQ-------VFEFLKGAITKNFKDDQIQNSSKFLQDLLPQ----FSSVSDMILDTVKNSVFGW 378

  Fly   380 DVITPGLVHLVFYLLKSQSPK-----------------MHTLAITFLTKFIRKRF---------I 418
            |.:|.|||.|.|.|:.|..||                 .:.||.....:.:.:.|         |
Zfish   379 DHVTQGLVQLGFILMDSFGPKPGPFGKVTEGTSSTAKTPNQLACRLGGQVLLESFKMHEPIRGEI 443

  Fly   419 FGQGIIKLISEWMIVYQEQNQFSECLTLLSVADTYTVSECMKPIQSVLEHMQWLSGEQSMRMMNF 483
            ..|.:.:|:::   .......|.:.|:.:.::....:.|....:....:.:.:|.......::..
Zfish   444 LEQVLNRLVTK---TASPVTHFIDLLSSIVLSAPMILLESSSKVTETFDQLSYLPLSTVQGLLKA 505

  Fly   484 ILPLLKISNRVRDALIDVLCKAMSSSGIQKRRMAIYGFCMILK--QLNNSNAVRQTSSATSFCTQ 546
            :.||||:|..::||||.||.|||.||.:..|:.|:.||.::||  ::..|.|..|.|.|.:
Zfish   506 VQPLLKVSMSMKDALILVLRKAMFSSHLDGRKSAVAGFLLLLKNFRILGSLASSQASQAIT---- 566

  Fly   547 HSISGYSIMTQNTLGSRSNPQRNFDMLTLEIIGMLRNCLQQQFDIRCSLYENLQRAVELNAKLVP 611
                  |...|..:.||.|...| :...|||:..||.||.||.|:|..|||.....:..|::|..
Zfish   567 ------SSQVQADVHSRYNTAAN-EAFCLEILSSLRRCLNQQADVRLMLYEGFHDVLRRNSQLAS 624

  Fly   612 HVLQVIDWHFRSFFDTPSAEDAGDDLDTVFRIRYDQLVSSSDDQHMEIQLKDNLGKLIQFVANCL 676
            .:.|.:....:.:|:        .:.|.:..::.:..:|:..||   :.|::.|..|:....:||
Zfish   625 SITQTLLSQLKRYFE--------PEQDLLPPVKLESCISAQGDQ---VFLQEPLAHLLCCTVHCL 678

  Fly   677 AVFDRAPSGYDT--------------REMNRLMSFCVDRMVANRLPLEEITPPATHLKC------ 721
            .......||.:.              .|:..::.....||:.:.|...|:.      ||
Zfish   679 LWNQNVRSGGNVSDDEDDEEDVGGVESELQAMLESITKRMIKSELEDFELD------KCAEFSTG 737

  Fly   722 ----------ALVLQQLNIIEGIICHLLLKSKPQNNAVCQILPLFNQHCKLLESLKALSDASKKA 776
                      |:::..||  |.::.:..:.:....|....:|.||.::.|:.:.|:
Zfish   738 SSVGVKNSIYAVLVMGLN--EVLMEYNFITANYSKNHFEDVLELFKRYLKVCDILR--------- 791

  Fly   777 HKQLKQTAKNNSTSTCNLTLNGVPVKTMCTQPDNIWDLAILDKLLHLLLDDVVAFAAPEKTVLLR 841
                ::..|....|:          ||    |.::..|..:..||..|..|... :..|...:||
Zfish   792 ----ERAGKGRPASS----------KT----PRSLLSLGFVSTLLTALFRDSTQ-SREESLSVLR 837

  Fly   842 SNEPLVRYVLSVTASRVESIR----------LEPDYKQLAYSKRTFKQLTDITKVI---YERCIQ 893
            ||...:||.:||...:::.:.          ..||        :||:.|.|||.|:   |.....
Zfish   838 SNGDFLRYSVSVALQKIQQLEETGHTDGPEGQSPD--------KTFRHLCDITSVLMWRYTNVPS 894

  Fly   894 RLPELWKNFDMQSAALATQCFSECLK---TAHETYSKKFEDFVKSFDLA----SIKGSRNKEVVY 951
            .:.:..|....||.:|.  |....|:   |..:.|..:..:|:.|.|::    ..|....::..:
Zfish   895 TVEDAGKKEKGQSVSLL--CLEGLLRVFTTVLQRYPTRVSNFLSSLDVSGEGEGDKSDLTEQTAF 957

  Fly   952 TIQDVLDDFMTEYGTDDSICKNEFVSKLPVYLLESLEILLDHIDYQDRAATESYTWLLNFCSKN- 1015
            .|:......|.:....:    .||.||....|:..|.:|...:....:...:..||.:..|.:.
Zfish   958 YIRQFQRALMNQLSGPE----EEFNSKEAQLLVSILSVLSRQLSPSSQQFLQMITWTVKICKETN 1018

  Fly  1016 -EILNSEMGLVHRM--LFVQRQKTHLGP------FFDSVARQLGHVLGVQNEDAPSESVELTLKS 1071
             |.:....||:..:  |:|    .|..|      ....:..|||.:......:..|....:.:|:
Zfish  1019 FEDIALTKGLLSLLFSLYV----LHKSPVSLLWEMCQDIHSQLGDIDQDVEVEKQSHFAIICMKT 1079

  Fly  1072 ISTVTIESCLQHLYAAIQKQLNDVDYFVTKANNLNYKCQVVPEIDQIYWR----------GNLDS 1126
            .::.|::     :.:.:.|.|::||:.:.|.     |.|:..:      |          |..|.
Zfish  1080 AASTTLQ-----VLSQVGKVLDEVDWLIAKK-----KAQISSD------RTISGNTQQPLGQQDP 1128

  Fly  1127 MDRSICTQIIHISRTLLVLTNVCIPLGSLMDGLMKLLIQHYTCLKSLTKHYISSYTSDTSIENIK 1191
            ::::|..|:..:...|..|....:|.|:..|.||:.|.:.|..|.:|||:||....:.   ....
Zfish  1129 IEKAITIQLGTLLTALHELVQTALPTGACTDTLMRELSRTYCILTTLTKYYIQLCATQ---PGQL 1190

  Fly  1192 STKFELLLRAVGKQLPANIYELITYIEANTLDEEAQQHTKKRK-----VQAERAKVLRETRLIPK 1251
            ..:.|.|::..|..|....|..|||:::..|.....:..||:|     |.|..|||||||:.||.
Zfish  1191 PARLEKLVKLSGSHLTPQCYCFITYVQSGELTAGGSEKLKKKKKEEEAVAAASAKVLRETKAIPN 1255

  Fly  1252 VIMVIEDFNKHIILLSKKTKSKNRLTDYLHLGTMRDFDIKSTDLRAAIERSISDGRNISTEDSNA 1316
            :|..||.:.|.:|||||  |||..|..|:.|.|.|||.|.:..|.||::
Zfish  1256 LIFNIEQYEKFLILLSK--KSKVNLMQYMKLSTSRDFRINAATLEAALQ---------------- 1302

  Fly  1317 EDRDEDEDENENVEEDDDAQSTTYPEDLEEKEDECL---VIEKKEERRRRRAPSSEAEDPQPKRK 1378
               ::::|:::.|.........|:.:  |....:|.   |...|..|.:.:           ::|
Zfish  1303 ---EQEQDQSQQVSLSKQPHLQTHLQ--EFSRFQCFFPSVFRVKMLRVKHQ-----------RKK 1351

  Fly  1379 RGRKAAEQLEA 1389
            .||.....|::
Zfish  1352 GGRSERRSLQS 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FANCI	NP_610429.2	FANCI	37..1293	CDD:212594	315/1379 (23%)
fanci	XP_021326126.1	FANCI_S1-cap	7..59	CDD:317118	8/36 (22%)
fanci	XP_021326126.1	FANCI	47..1295	CDD:212594	317/1390 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576370
Domainoid	1	1.000	96	1.000	Domainoid score	I7300
eggNOG	1	0.900	-	-		E1_KOG4553
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49530
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3200
OMA	1	1.010	-	-		QHG60155
OrthoDB	1	1.010	-	-		D116753at33208
OrthoFinder	1	1.000	-	-		FOG0006301
OrthoInspector	1	1.000	-	-		oto41222
orthoMCL	1	0.900	-	-		OOG6_104620
Panther	1	1.100	-	-	LDO	PTHR21818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4053
SonicParanoid	1	1.000	-	-		X5252
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800