DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FANCI and fnci-1

DIOPT Version :9

Sequence 1:	NP_610429.2	Gene:	FANCI / 35895	FlyBaseID:	FBgn0033354	Length:	1481	Species:	Drosophila melanogaster
Sequence 2:	NP_001021652.1	Gene:	fnci-1 / 189113	WormBaseID:	WBGene00020935	Length:	1437	Species:	Caenorhabditis elegans

Alignment Length:	1612	Identity:	290/1612 - (17%)
Similarity:	573/1612 - (35%)	Gaps:	425/1612 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RSLGEKARFDELELLIQNTP--IEKLKETLKSTMTRSEGI----TYWNYLLRGF-NPESKDALAK 59
            |..|.:...|.|....|..|  :..:.||.|:.:..:.||    ..|:.|.|.. ...|.|...:
Worm    13 RGGGTEKFVDALIKFRQKHPDNLNSVSETSKNAVITNLGILNNDNKWSSLERLLVQMCSDDRGGR 77

  Fly    60 RFECVRSFMDGLS-------STELSYKQTFDLITRLSQDLATFPS-----EQLAWIVEHCMD-GI 111
            .||...|....||       :..||.:....|:..|::...:.|:     ..|...||:..: |:
Worm    78 MFEFTHSIFTLLSILPNPTDAENLSIRTIKFLLNTLTKATVSVPNFFGMYNDLMVQVENISNYGL 142

  Fly   112 RQGDAKCVGWKDLLPDALSLLLARPRFLLNGISIDGMEFRDTTVRSIATMQWPASILTPIADMFK 176
            .|           |.|.:|::|.|..           |::|.....              ||  .
Worm   143 TQ-----------LVDYVSIMLKRAN-----------EWKDQAEGE--------------AD--D 169

  Fly   177 TMNLSSGE---------------IVTVLNKFSGALQ-ELSPMELPAL------------------ 207
            |.|::.|:               :...:.|.....| ||....||..
Worm   170 TENVARGKNNNSKMSFNQRWKDFVAVFIKKVRDIDQIELDDELLPGSDAADNILFEWLKTTEDVD 234

  Fly   208 CFQLFSMCSTASQLIIPLLALEKYFHRNYYKRLFSDMCSNSTNLDS------------------- 253
            .|:|.|..|.:|...|...:::::......:::..|  ::|.::||
Worm   235 AFELISEISASSSSGITTPSIDRFCDEVIVEKIGID--TSSDDMDSERKRRSIMTWKSLILTTKT 297

  Fly   254 ---------------IDLFSDKELREAEE-TILHHLNYCTMYKLTEKHLAIML-----RNFLHM- 296
                           .::..|:|..:.|: .|..||..|    ||..|..:.:     :.||..
Worm   298 EKERLGRLWNGIICAWEISEDEEKEKMEQRKISEHLEKC----LTVGHRILNINVESAKKFLTFI 358

  Fly   297 -PD---VILTPFMLSAIISMTSINRDPESARISHSILLPFLRNVIKNNEEERTLADYSVWYRDTL 357
             .|   |:.:.|.|...:....::|:.....:..:     .:.:.|..|:    |:..:|..|.:
Worm   359 RTDKYRVLSSEFGLCLCLIQCCLDRNDAMMDMKKT-----FQKLWKIGEQ----AEECLWMSDIV 414

  Fly   358 QR---KQVDLQ-QVLTVLIDQNKDGKDVITPGLVHLVFYLLKSQSPKMHTLAITFLTKFIRKRFI 418
            ..   :.|||| ::::..:..|::.:.:::..|:.|:..||.:.:.:...:.:..........::
Worm   415 CGRIIRLVDLQLRIISENLHSNENLRRILSRPLISLMLSLLDTPAYQKQVVVVDGRVADGCTLWL 479

  Fly   419 FGQGIIKLISE------------WMIVYQEQNQFSECLTLLSVADTYTVSEC-------MKPIQS 464
            ..:.|:.::|:            :..:....|. |..|.|:.|. ...|.:|       .|.|..
Worm   480 LSRDILIIVSQADVDMGAQLSHLFKSIASSSNN-SSALILIDVL-RELVRKCSVEILNNSKLIDG 542

  Fly   465 VLEHMQWLSGEQSMRMMNFILPLLKISNRVRDALI-----DVLCKAMSSSGIQKRRMAIYGFCMI 524
            :.:::..:..:.::.::..::|::....::|:||.     |:||::...|.:.          ::
Worm   543 LFDYVCRMRKDIAVSLIRCLIPIINTRPQLRNALFKSLKKDLLCESTVGSAVP----------IV 597

  Fly   525 LKQLNNSNAVRQTSSATSFCTQHSIS----GYSIMTQNTLGSRSNPQRNFDMLTLEIIGMLRNCL 585
            |..|.:.:..|:......|  .||:|    .:|..|.|::|.:.|..:.   :.||::|:::.||
Worm   598 LILLRSVSKRREDGGGGQF--DHSMSQSFGTFSTQTLNSMGLKKNVDQT---VGLELVGIIKRCL 657

  Fly   586 QQQFDIRCSLYENLQRAVELNAKLVPHVLQVIDWHFRSFFDTPSAE---DAGDDLDTVFRIRY-- 645
            .|....:.:||:.:.......:.::...|.:|..|.|...:...:|   ..|:.:..|..|.:
Worm   658 WQPVKTKIALYDGICELATQTSTMLNQFLDMILSHARMIPEWKKSEMTVSIGNIVQIVEPIPHLI 722

  Fly   646 ---DQLVSSSDDQHMEIQLKDNLGKLIQFVANCLAVFDRAPSGYDTREMNRLMSFCVDRMVANRL 707
               :.|:|.......|.:| :....|::..||.:.::.......|..:|.      :|:.:
Worm   723 QTMECLMSELLSHDPEFKL-EGTELLLRPAANQMEIWVTTAMRNDVSDMG------LDKNI---- 776

  Fly   708 PLEEITPPATHLKCALVLQQ--LNIIEGIICHL------------------LL------------ 740
               |.|....:.:|:|:..|  |:..:.:|.|:                  ||
Worm   777 ---EWTTATVNGRCSLLFAQMMLSTYDVLIEHMWRRVETTESKEDADKIVALLARRSELDILYKE 838

  Fly   741 -----KSKPQNNAVCQILPLFNQHCKLLESLKALSDASKKAHKQLKQTAKNNSTSTCNLTLNGVP 800
                 |.|.:.....:.:.:.:...::|.|.|.||....|    |.:.|:|:..||.|.|:|
Worm   839 KTTTKKEKDKEKEKEEKITIDSSQSEILTSAKTLSSIMTK----LIKPAENDGNSTANATIN--- 896

  Fly   801 VKTMCTQPDNIWDLAILDKLLHLLLDDVVAFAAPEKTVLLRSNEPLVRYVLSVTASRVESIRLEP 865
                 .:|:.:.|:.:      .||..||..|....:.|::...|| ..:||.|:|   .|.|..
Worm   897 -----VRPEIVADVQM------ELLVWVVGRAKVLSSALVKEYRPL-HSILSGTSS---LISLSK 946

  Fly   866 DYKQLAYSKRTFKQLTDI-----TKVI----YERCIQRLPELWKNFDMQSAALATQCFSECLKTA 921
            ....|.........:::|     |:.:    |...:|.|.   ..|......|.:..|.|.....
Worm   947 SLIDLYMGNNCSSWVSEIDTGSPTRTLAIESYANILQFLS---IKFKQTPTRLTSAWFEEKDGED 1008

  Fly   922 HETYSKKFEDFVKSFDLASIKGSRNKEVVYTIQDVLDDFMTEYGTDDSICKNEFV--SKLP--VY 982
            .||..|:.|..:.:...|.....|      ..:.::|            .:||.:  .|.|  .|
Worm  1009 EETKRKRQEPNIVALRQAHFLSCR------LFRQIID------------VENEEIEEEKKPKAQY 1055

  Fly   983 LLESLEILLDHIDYQDRAATESYT-------WLLNFCSKNEILNSEMGLVHRML-----FVQRQK 1035
            .::...||        :||:.:.:       |...|....::|..|....::||     |:....
Worm  1056 EMQGRAIL--------KAASAALSLTKNVKVWSNLFTRVVKVLEDETFYNNQMLRDYCKFIITCS 1112

  Fly  1036 THLGPFFDSVARQLGHVLGVQNEDAPSESVELTLKSISTVTIESCLQHLYAAIQKQLNDV----- 1095
            ........:.|.::..::....|....|:.|:....||..||...::..:..::|.|..:
Worm  1113 LRCADSDKTTAIEMHEIMENILEFLSEENEEMKYHFISKTTINVSIEFQFMFVEKTLALIRDAFT 1177

  Fly  1096 ---DYFVTKANNLNYKCQVVPEIDQIYWRGNLDSMDRSICTQIIHISRTLLVLTNVCIPLGSLMD 1157
               |:||.            |.:        .|:|..::.|:.:.::..:..:..:.:....:.:
Worm  1178 FQKDFFVK------------PPV--------FDNMLCTLLTKCLEVTELVSRILQIFVQYKMMQE 1222

  Fly  1158 GLMKLLIQHYT-------CLKSLTKHY---ISSYTSDTSIENIKSTKFELLLRAVGKQLPANIYE 1212
            .:.:::..::|       .|::|||.:   :|.:.|...:..:..||...:|..|...:..:
Worm  1223 RVTEIMTSYFTTIQMGVVLLQNLTKGWGKEMSEWQSTNILATLVKTKLRPILAMVDDHIGFS--- 1284

  Fly  1213 LITYIEANTLDEEAQQHTKKRKVQAER-AKVLRETRLIPKVIMVIEDFNKHIILLSKKTKS---- 1272
                        :.:...||:..|..| ||..|:.:|..|.....|.....|::|.|..|.
Worm  1285 ------------KGKDEMKKKISQKTRYAKSKRDEKLFSKFSHEREAVQHGILVLCKLIKDDRFD 1337

  Fly  1273 ---KNRLTDYLHLGTMRDFDIKSTDLRAAIERSISDGRNIST-EDSNAEDRDEDEDENENVEEDD 1333
               ||....|      |||.|....||    ..:|...|... |.:....|.:...|:|.:||.:
Worm  1338 LQIKNNSIGY------RDFRIDMEVLR----NKLSGQANEEVCEPATKRGRRDPSMEDEEIEETE 1392

  Fly  1334 DA-----QSTTYPEDLEEKEDECLVIEKKEERRRRRAPSSEAEDPQPKRKRG 1380
            ::     :|:..||:..::|:...|:::            |.:|.:....||
Worm  1393 ESTTSARRSSEEPEEPRDQENTVGVVKQ------------EVDDEEESVSRG 1432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FANCI	NP_610429.2	FANCI	37..1293	CDD:212594	262/1480 (18%)
fnci-1	NP_001021652.1	FANCI_S2	<519..582	CDD:373215	9/63 (14%)
fnci-1	NP_001021652.1	FANCI_HD2	618..833	CDD:373219	44/231 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104620
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4053
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860