Protein Alignment FANCI and fanci

DIOPT Version :10

• Sequence 1: NP_610429.2
• Gene: FANCI / 35895
• FlyBaseID: FBgn0033354
• Length: 1481
• Species: Drosophila melanogaster
• Sequence 2: XP_012815006.2
• Gene: fanci / 100038061
• XenbaseID: XB-GENE-981363
• Length: 1339
• Species: Xenopus tropicalis
• Alignment Length: 1483
• Identity: 355/1483 - (23%)
• Similarity: 620/1483 - (41%)
• Gaps: 272/1483 - (18%)

  Fly     3 SLGEKARFDELELLIQNTPIEKLKETLKSTMTRSEGITYWNYLLRGF---NPESKD-ALAKRFEC 63
            ||..:.:.:.|:..:||....:|.|.:.....:.:..   ..||||.   :|.|:| |:.:|...
 Frog     7 SLAAEDKNEGLQCCLQNLKETELLEIITKHAVKGKEC---GALLRGIFRGSPCSQDVAVQRRLTV 68

  Fly    64 VRSFMDGLSSTELSYKQTFDLITRLSQDLATFPSEQLAWIVEHCMDGIRQGDAKCVGWKDLLPDA 128
            .|..:..:.|.:|..:...:::..|..::..||...|..:....:|.::.|........||.|..
 Frog    69 YRHCIQLVESGDLQREVASEIMGLLMLEVHLFPGASLIELANLFVDAVKGGSLSNGKSLDLFPTV 133

  Fly   129 LSLLLARPRFLLNGISIDGMEFRDTTVRSIATMQW-PASILTPIADMFKTMNLSSGEIVTVLNKF 192
            ||.|.::.........:.|.||:...:.|:.:.:| |.|::. :..||:.::||..|:..|:.|.
 Frog   134 LSALSSKESLAYGKGELTGEEFKKQLINSLCSSRWDPQSVIF-LTSMFRDVSLSVEELQFVVEKV 197

  Fly   193 SGALQELSPMELPALCFQLFSMCSTASQ--LIIPLLALEKYFHRNYYKRLFSDMCSNSTNLDSID 255
            ...|.:|...|:|.|.:||..:.:..|:  ::..::.:   |:....|:|.....|.|.:|:...
 Frog   198 LRMLSKLDLQEMPPLVYQLLLLSAKGSKKNIVEGIITI---FNDLDQKQLIQQENSISLDLEDAT 259

  Fly   256 LFSDKELREAEETILHHLNYCTMYKLTEKHLAIMLRNFLHM-----PDVILTPFMLSAIISMTSI 315
            :..| :|...|.||:.|:.:.  .|| ::.|...|..:|..     ...||.||..:.::|::.|
 Frog   260 IPQD-QLCHVEGTIILHIVFA--IKL-DQELGRELLKYLKAGQQGDTSKILCPFSAALLLSVSRI 320

  Fly   316 NRDPESARISHSILLPFLRNVIKNNEEERTLADYSVWYRDTLQRKQVDLQQVLTVLIDQNKDGKD 380
            :|..|.       :..||::.|....::......|.:.:| |..:...:..:|...:..:..|.|
 Frog   321 HRFQEQ-------VFDFLKSTILRVYKDHQFHQSSKFLQD-LVPQPACVSSILLKTVKNSVYGWD 377

  Fly   381 VITPGLVHLVFYLLKSQSPK-------MHTLAITFLT----------KFIRKRFIFGQGIIKLIS 428
            .:|.|||.|.|.|:.|..||       :.|:::...|          :.:.:.|...:.|...|.
 Frog   378 HVTQGLVELGFILMDSFGPKAAFGTKVVETISVNSRTPAQQACQLGSRILLEAFKVHEPIRSEIL 442

  Fly   429 EWM---IVYQEQNQFSECLTLLS---VADTYTVSECMKPIQSVLEHMQWLSGEQSMRMMNFILPL 487
            |.:   ::.:..|..:..|.|||   |:....:......:....:|:.:|.......::..:.||
 Frog   443 EQVLNRVITKAANPVTHFLDLLSDIVVSAPLILQNSSSKVTEAFDHLSFLPLTTVQGLLKAVQPL 507

  Fly   488 LKISNRVRDALIDVLCKAMSSSGIQKRRMAIYGFCMILKQLNNSNAVRQTSSATSFCTQHSISGY 552
            ||||..:||:||.||.|||.||.|..|:.|:.||.::|:   |...:...||  |.|:| :|...
 Frog   508 LKISMSMRDSLILVLRKAMFSSQIDARKSAVAGFLLLLR---NFKVLGSLSS--SQCSQ-AIGAS 566

  Fly   553 SIMTQNTLGSRSNPQRNFDMLTLEIIGMLRNCLQQQFDIRCSLYENLQRAVELNAKLVPHVLQVI 617
            .|  |..:..|.|...| :...|||:|.||.||.||.|:|..|||.....:..|::|...|:|.:
 Frog   567 QI--QVDVHMRYNAAAN-EAFCLEILGSLRRCLSQQADVRLMLYEGFYDVLRRNSQLASSVMQTL 628

  Fly   618 DWHFRSFFDTPSAEDAGDDLDTVFRIRYDQLVSSSDDQHMEIQLKDNLGKLIQFVANCLAVF--- 679
            ....:.:::        .:.|.:..::.:..:::..|   .|.|::.|..|:..:.:||..:
 Frog   629 LSQLKRYYE--------PEPDLLPPLKLEGCITAQGD---HIFLQEPLAHLLCCIHHCLHWYKSS 682

  Fly   680 ---DRAPSGYDTREMNRLMSFCVDRMVANRLPLEEITPPATH--LKCALVLQQL------NIIEG 733
               .|.|...|..|.|.......|        |.:|....|.  :||.|...:|      ::..|
 Frog   683 LLQHRNPDDDDDDEDNDHTGCQQD--------LHDILESITRRMIKCDLEDFELDKSADFSLASG 739

  Fly   734 I-------------ICHLLL----------KSKPQNNAVCQILPLFNQHCKLLESLKALSDASKK 775
            :             ||.:|:          |||.::     ||.||..:.||.:.||      :|
 Frog   740 VGVKNNIYAVLVMGICEVLIEYNFIIANFSKSKFED-----ILGLFKCYSKLSDILK------EK 793

  Fly   776 AHKQLKQTAKNNSTSTCNLTLNGVPVKTMCTQPDNIWDLAILDKLLHLLLDDVVAFAAPEKTVLL 840
            |.|. :|...|....                   ::..:..:..||..|..|... :..|...:|
 Frog   794 AAKG-RQPGNNKMAR-------------------SLISMTFVSTLLTALFRDSTR-SHEESLSVL 837

  Fly   841 RSNEPLVRYVLSVTASRVESIRLE-------PDYKQLAYSKRTFKQLTDITKVIYERCIQRLPEL 898
            |:|...:||.:.|...:::  :||       ||.:.   |::.|:.:.:||:|:          :
 Frog   838 RANMDFMRYSVCVALQKIQ--QLEETGVTDGPDGQN---SEKMFQSICEITRVL----------M 887

  Fly   899 WKNFDMQSAA-----------LATQCFSECLK---TAHETYSKKFEDFVKSFDL---ASIKGSRN 946
            |:...:.:||           ::..|....|:   |..:.|..|...|..:.|.   ...:|:|.
 Frog   888 WRYNSIPTAAENPGKKDKGKNISLLCLEGLLRVFNTIQQRYPSKIPQFFTALDALGEEDEEGARE 952

  Fly   947 KEVVYTIQDVLDDFMTEYGTDDSICKNEFVSKLPVYLLESLEILLDHIDYQDRAATESYTWLLNF 1011
            ..|.......:..|........|..:::|.||..:.|:..|..|...:........:..:|.:..
 Frog   953 INVTEKAAFQIKQFQRSLINQLSGGEDDFNSKEALLLVSILSTLSRLLAPSSPQFVQMLSWTVKI 1017

  Fly  1012 CSKNEILNSEM--GLVHRMLFVQRQ-KTHLGPFFDSVARQL-----GHVLGVQNEDAPSES---- 1064
            |.:..|.:.:.  ||::.:..:..| |:.:     ||.|:|     || ||..::|...|.
 Frog  1018 CKETNIEDVQFCKGLMNLLFSLHAQFKSPV-----SVLRELCQDIHGH-LGDIDQDIEVEKQSHF 1076

  Fly  1065 VELTLKSIS-TVTIESCLQHLYAAIQKQLNDVDYFVTKANNLNYKCQVVPEIDQIYWRGNLDSMD 1128
            ..::||:.: |||:     .:.|...|.|.:||:.:.|...|....::..| |..........::
 Frog  1077 ASVSLKTAAPTVTL-----LVLAQAAKVLEEVDWLIIKLKGLLGSEKLSTE-DLTQTSNARLPIE 1135

  Fly  1129 RSICTQIIHISRTLLV----LTNVCIPLGSLMDGLMKLLIQHYTCLKSLTKHYI---SSYTSDTS 1186
            ::|..|:    .|||.    |....:|.||..:.|:|.|.:.||.|.|:.|:|:   ||:....
 Frog  1136 KAIILQL----GTLLTACHELVQTALPAGSCTETLLKELAKMYTILTSVVKYYLQICSSHGGQI- 1195

  Fly  1187 IENIKSTKFELLLRAVGKQLPANIYELITYIEANTLDEE---AQQHTKKRKVQAE---RAKVLRE 1245
                 |.:.|.|::..|..|....|..|||:: |...|.   |.:..||:|.:|.   .||:||:
 Frog  1196 -----SARLEKLVKLSGSHLTPQCYAFITYVQ-NIHSESLSLAGEKKKKKKEEASTVTTAKILRD 1254

  Fly  1246 TRLIPKVIMVIEDFNKHIILLSKKTKSKNRLTDYLHLGTMRDFDIKSTDLRAAIERSISDGRNIS 1310
            |:.||.:|..||.:.|.:|.|||  |||..|..|:.|.|.|||.|.:..|.||:
 Frog  1255 TKPIPNLIFAIEQYEKFLIHLSK--KSKVNLMQYMKLSTSRDFRINAATLDAAL----------- 1306

  Fly  1311 TEDSNAEDRDEDEDENENVEEDDDAQSTTYPEDLEEKEDECLVIEKKEERRRR 1363
             ::..:|| :|:|.:||....::.:|                  |.|::|||:
 Frog  1307 -QEKGSED-EENEPDNEQTVTEEQSQ------------------EPKKKRRRK 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCI	NP_610429.2	FANCI	37..1293	CDD:212594	333/1377 (24%)
fanci	XP_012815006.2	FANCI_S1-cap	1..53	CDD:434117	11/48 (23%)
		FANCI	41..1300	CDD:212594	333/1377 (24%)