Protein Alignment PAN2 and PAN2

DIOPT Version :10

• Sequence 1: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_001120932.2
• Gene: PAN2 / 9924
• HGNCID: 20074
• Length: 1202
• Species: Homo sapiens
• Alignment Length: 1290
• Identity: 525/1290 - (40%)
• Similarity: 731/1290 - (56%)
• Gaps: 167/1290 - (12%)

  Fly     7 GTDPIGASEDILSVYDAGSAPGNGHFSPSFNGFNIGTTDPE-------------------YVELV 52
            |.|| |.:|...:::.|.....:.|.:||... |: ..|||                   |.||.
Human     5 GLDP-GLAEYAPAMHSALDPVLDAHLNPSLLQ-NV-ELDPEGVALEALPVQESVHIMEGVYSELH 66

  Fly    53 PVLADGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGV 117
            .|:|:.|....||.  ||.:||:||:|:.|||.||::..::::|:||||:.:|.:|.|.:|::|:
Human    67 SVVAEVGVPVSVSH--FDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIRQIQSLENGI 129

  Fly   118 LALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGLQDELIDFDLRTLKETRIEHV 182
            |.||:.:|::..|.||..|.:..:..::|.|:|......|::.|||:.:|:.||.|::||:...|
Human   130 LFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAV 194

  Fly   183 GAGGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGRQN 247
            ...|.|::|:.:|:.|.|...|.|:||||.:..|:|.....:..||||.|.||||.:||:|.|..
Human   195 ETPGVTIMRQTNRFFFCGHTSGKVSLRDLRTFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLT 259

  Fly   248 NLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSM 312
            .||.||||.||||||:|.|.|:||.:||..|:|:|:.||:||::|..||.|..:...|:.| ..:
Human   260 GLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANP-ADI 323

  Fly   313 YQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFA--DVVPQLPMV 375
            :.:|..|...::||:|:|.||:||||..|.:::  ...:|:|.||.|||.||||  .:|..||.:
Human   324 FHVNPVGPLLMTFDVSASKQALAFGDSEGCVHL--WTDSPEPSFNPYSRETEFALPCLVDSLPPL 386

  Fly   376 SITDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGYSPNPRTA 440
            ..:....|||.:.:| |||.| ..||||.........|...:|.|:|..||..|.|||:|||||.
Human   387 DWSQDLLPLSLIPVP-LTTDT-LLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTR 449

  Fly   441 RRNQIPYVIEQGG---------VCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDF 496
            .||||||.:::..         ..||.|.      :.|..:.::.::||||.:||:|||.:||||
Human   450 LRNQIPYRLKESDSEFDSFSQVTESPVGR------EEEPHLHMVSKKYRKVTIKYSKLGLEDFDF 508

  Fly   497 DQHNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTAS 561
            ..:|:|.|||||..:||:|||.|:|:|||.:.:|..:..|.|.|||||:|||||||:|||.| ..
Human   509 KHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLS-RG 572

  Fly   562 SPCQASNFLRSFRTVPEASALGLILTD---RSSNVNLISLIQNWNRFILHQMHYEIFDSSKNAST 623
            .|||.:||||:|||:||||||||||.|   .|...||..|||.||||||.|:|.:: ...:....
Human   573 DPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDM-QELEIPQA 636

  Fly   624 YSGSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAETDISKIFGTKQICINRCI 688
            |.|          ||.|....|.|                       :.|.::|..:....:.|
Human   637 YRG----------AGGSSFCSSGD-----------------------SVIGQLFSCEMENCSLC- 667

  Fly   689 KCQEEKIKESILLACNLSYPNHIKD--SDQYFNFGTILKRSLSSEKSIQAFCERCKKFSPTNQSV 751
            :|..|.::.|..|...||||:..|.  :.:.::|..:||||:..:::.||:|:.|:|:.||.|:.
Human   668 RCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTR 732

  Fly   752 KVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLSTSKPCRYGANCSRSDCHFMHP 816
            .:..||.||.|||.:|:.|:..|.:.|         .:.|..::..|   :|...|::. .|...
Human   733 NIRHLPDILVINCEVNSSKEADFWRMQ---------AEVAFKMAVKK---HGGEISKNK-EFALA 784

  Fly   817 DRKSPSHTSQPNAVNNSPNGRQ--KSWFPLTFTMGINDQGEVQVQTQSDASS---GKSEQEEETE 876
            |.|   ....|..|...|:..:  ..|.|.:..|.:.....:.|...:|...   |.:..|||
Human   785 DWK---ELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQWGPARAEEE-- 844

  Fly   877 KPPTKGLDNNRMYALHAVVCQV-DDGTQKNLVSLINVQRPYHTMKLAESADDPQSQWYIFNDFSI 940
                .|:   .:|.|.|.|..: |..|..:||:.|.|...||..|...:    ..|||:||||.|
Human   845 ----HGV---YVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVT----HQQWYLFNDFLI 898

  Fly   941 SPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTSSTVTESEETIPSESSSGSPTNLSNPFLE 1005
            .|:...|:|.|.::||||.||:|                       :....:|....|:.||...
Human   899 EPIDKHEAVQFDMNWKVPAILYY-----------------------VKRNLNSRYNLNIKNPIEA 940

  Fly  1006 EIVSPMLGNLSADATLQ-----------PLQSDEMPQSGDLVAMDAEFVTLNPEENEIRPDGKTA 1059
            .:       |.|:|:|.           ||..:||||.||||.:||||||||.||.|:|.||..:
Human   941 SV-------LLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKS 998

  Fly  1060 TIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRLTALK 1124
            ||||..||||||:|:|||||.||:||:||||||||:|||||||:||||||||||..|.|.||.||
Human   999 TIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLK 1063

  Fly  1125 YSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMVSLRFLAWHFLGTK 1189
            .:|.||::|:|:||.||||||:.||||||:.||.:|::|||:|||||..||:|||||||:||..|
Human  1064 STYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLK 1128

  Fly  1190 IQSETHDSIEDARTTLQLYKHYLKLQ----EEKKFANALKNLYERGKQLQWKVPE 1240
            ||.|||||||||||.||||:.||:|.    |.:.|...||.|||:|:::.|||||
Human  1129 IQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPE 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:475233	88/206 (43%)
		WD40 repeat	148..183	CDD:293791	12/34 (35%)
		WD40 repeat	187..221	CDD:293791	13/33 (39%)
		WD40 repeat	227..273	CDD:293791	30/45 (67%)
		WD40 repeat	278..314	CDD:293791	13/35 (37%)
		UCH_1	505..940	CDD:463872	151/445 (34%)
		zf-CCCH_2	799..816	CDD:464217	3/16 (19%)
		PAN2_exo	1036..1209	CDD:99846	124/172 (72%)
PAN2	NP_001120932.2	WD 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	153..193		14/39 (36%)
		WD 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	195..231		14/35 (40%)
		WD40	<204..357	CDD:475233	69/152 (45%)
		WD 3. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	244..280		21/35 (60%)
		WD 4. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	328..367		19/40 (48%)
		Linker. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	368..485		44/125 (35%)
		UCH_1	517..898	CDD:463872	126/391 (32%)
		PAN2_exo	975..1148	CDD:99846	97/183 (53%)