DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and REX4

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_014561.1	Gene:	REX4 / 854075	SGDID:	S000005440	Length:	289	Species:	Saccharomyces cerevisiae

Alignment Length:	293	Identity:	76/293 - (25%)
Similarity:	124/293 - (42%)	Gaps:	63/293 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   964 RHVEDDSESASTTSST------------VTESEETIPSESSSGSPTNLSNPFLE----------E 1006
            |:|:..|::.:.:|:|            :.:....:..|.|......|.....|          .
Yeast    31 RNVKKVSKTVNVSSTTQYAPRKRKNGSKIMDMVYNMNKEISKHEKDKLEGKVFEFNPNKANTSTT 95

  Fly  1007 IVSPMLGNLSADATLQPLQSDEMPQSGDLVAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARI 1071
            |..|:...:|.|..:...:|.|:   |..:|||.|||.:.||..|              .::|||
Yeast    96 IKEPVKVGISEDTRINSNKSKEI---GKYIAMDCEFVGVGPEGKE--------------SALARI 143

  Fly  1072 SCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDV 1136
            |.:...|..    .:|:::..:||||::.|..|||||..:      |.....|.:.:|...:::
Yeast   144 SIVNYFGHV----VLDEFVKPREKVVEWRTWVSGIKPEHM------KNAITFKEAQKKTADILE- 197

  Fly  1137 GVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMV------SLRFLAWHFLGTKIQSETH 1195
            |.|.|||.||:|...:.:..|...:.||..  |:|..::.      ||:.|....|...||...|
Yeast   198 GRILVGHALKHDLEALMLSHPKSLLRDTSR--HLPFRKLYAKGKTPSLKKLTREVLKISIQEGEH 260

  Fly  1196 DSIEDARTTLQLYKHYLKLQEEKKFANALKNLY 1228
            .|:||||.|:.|||     :|:.:|....:|.:
Yeast   261 SSVEDARATMLLYK-----KEKTEFEKIHRNTF 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	55/178 (31%)
REX4	NP_014561.1	REX4_like	122..274	CDD:99847	55/178 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810