DRSC/TRiP Functional Genomics Resources

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Protein Alignment PAN2 and AEN

DIOPT Version :9

Sequence 1:NP_610427.2 Gene:PAN2 / 35893 FlyBaseID:FBgn0033352 Length:1241 Species:Drosophila melanogaster
Sequence 2:NP_073604.3 Gene:AEN / 64782 HGNCID:25722 Length:325 Species:Homo sapiens


Alignment Length:268 Identity:73/268 - (27%)
Similarity:110/268 - (41%) Gaps:51/268 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   988 PSESSSGSPTNLSNPFLEEIVSP-----MLGNLSADATLQPLQSDEM-PQSGDLVAMDAEFVTLN 1046
            |...||..||........|..|.     ..|:.||..:.:|...... |.....||:|.|.|...
Human    57 PEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTG 121

  Fly  1047 PEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDL 1111
            |.       |:.:       .:||.|.:...|..    ..|.||..:..:.||.|::|||....:
Human   122 PR-------GRVS-------ELARCSIVSYHGNV----LYDKYIRPEMPIADYRTRWSGITRQHM 168

  Fly  1112 DANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHL---FHMP-- 1171
                  ::....:.:.:::..|:. |.:.|||.|.|||:.:....|..|..||.::   ...|  
Human   169 ------RKAVPFQVAQKEILKLLK-GKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGL 226

  Fly  1172 HHR-MVSLRFLAWHFLGTKIQ--SETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQ 1233
            |.| .|||:.||...|..|||  ...|.|:|||.|.::||: .:::|.|::.|.:|         
Human   227 HTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYR-LVEVQWEQQEARSL--------- 281

  Fly  1234 LQWKVPED 1241
              |..|||
Human   282 --WTCPED 287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PAN2NP_610427.2 WD40 63..>270 CDD:330360
WD40 repeat 148..183 CDD:293791
WD40 repeat 187..221 CDD:293791
WD40 repeat 227..273 CDD:293791
WD40 repeat 278..314 CDD:293791
UCH_1 505..940 CDD:315986
zf-CCCH_2 799..816 CDD:317060
PAN2_exo 1036..1209 CDD:99846 52/180 (29%)
AENNP_073604.3 Nucleolar localization signal 27..35
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..105 4/19 (21%)
DnaQ 106..314 CDD:223916 61/219 (28%)
DnaQ_like_exo 111..267 CDD:299142 52/180 (29%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18264133 165..188 1/29 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..325 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0847
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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