Protein Alignment PAN2 and zgc:152968

DIOPT Version :10

• Sequence 1: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_001314684.2
• Gene: zgc:152968 / 564848
• ZFINID: ZDB-GENE-061013-448
• Length: 1250
• Species: Danio rerio
• Alignment Length: 1480
• Identity: 245/1480 - (16%)
• Similarity: 450/1480 - (30%)
• Gaps: 558/1480 - (37%)

  Fly    42 GTTDPEYVELVPVLADGGEHFGVSSVAFDDY---EELLWMGNQGGHVTSYYTNSMQKYTSFQVHA 103
            |..||:...     |:|..|     ...|:|   |||..:..:...|.|......::.:.:|...
Zfish    43 GLGDPKVTS-----ANGSFH-----TTEDNYACLEELERINKEIEAVRSEVEKEQKRLSQYQTSQ 97

  Fly   104 TDIVRDISTLDSGVLALTQTS------LRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGL 162
                           :||||.      ||  ..:..|| ....|::|....:...|..:.|:...
Zfish    98 ---------------SLTQTGQCSGKYLR--TTKSRPK-DQNGNHLKSKKPVCSTSGQKYVVDRA 144

  Fly   163 QDEL-IDFD------------------LRTLKETRIEHVGAGGCT--VLRKNSRYLFAGDQLGTV 206
            :.:. :::|                  |::..:..|:|......|  :::..|.:....:..||:
Zfish   145 RPKTDLEYDPCSNFSADLLSSSSAECKLKSSDKVDIDHGLKSKQTGKIVQPLSSHFDDSEDKGTL 209

  Fly   207 TLRDLNSLSVQH----------TIKTHTNILSDFSVQGNLLISCGYSGRQNNLAIDRFLMVYDLR 261
            .: |:.||:..|          .||||.       ::.|..::...|.:|.|
Zfish   210 VI-DIPSLTKDHRKHKPKQESAIIKTHV-------LERNGAVNNDLSNQQTN------------- 253

  Fly   262 MLRLIAPIQVMIDPQMLK-----FLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSMYQINTNGSQ 321
                         |...|     .|||...:..:........||..:.::|.     |.::.|.
Zfish   254 -------------PNQHKEKSSDGLPSHDMKCTLSDQENARTLVKPMMITEE-----QESSEGE- 299

  Fly   322 CLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVS---------- 376
             |..|:|.      |.|:.         :.||.:   .:::.|..| :|:|..:|
Zfish   300 -LVIDVSQ------FEDEH---------KLPQQR---ETKNKELLD-LPKLCPISNAPAEHYKEA 344

  Fly   377 --------ITDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGY 433
                    ||..|.|...:        ..:..|..||         ...:|...:|:.|:..:
Zfish   345 NDGQIIKGITMANHPGKDI--------EPFLEDLREE---------PVAEPNNFTNINMETFV-- 390

  Fly   434 SPNPRTARRNQIPYVIEQGGVCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDFDQ 498
              ..:..:.:.:..|::....|..|....:...|....||::|     |...|
Zfish   391 --KQKEEKAHNLENVLDDISTCLNNMRSQSDELKTIQDVKMLP-----VNSVY------------ 436

  Fly   499 HNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTAS-- 561
             ...|   :.:..|.|    .||.|...:.      ::|.|..:.|..|     |:..|..:.
Zfish   437 -GDEC---ISSQFPRS----ALQNLTSREP------QNSSISGYALKSE-----NVSSKDISQIH 482

  Fly   562 ---SPCQASNFLRS-FRTVPEASALGLILTDRSSNVNLISLIQNWNRFILH-------QMHYEIF 615
               .|..:|..|.| .....|...||...|...:..:.::|..:.....:|       ::.:.:.
Zfish   483 QQYFPMVSSQSLPSPLHKAEEHRFLGPPHTQSLTETSWVTLQSSHGEPFVHNTPAYVSEIDFGVV 547

  Fly   616 DSSKNAS-----------------TYSG----SVQTSTNAENAGSSETSGSSDLYDSISDENSKE 659
            .:..|:.                 :||.    :|.:.|.|..||:   :....:.||.||...:.
Zfish   548 SAPSNSQLNPRTVESIEKLPTSNVSYSAACDMTVPSQTFATMAGN---NNEPIVVDSSSDAELRY 609

  Fly   660 DDRERSKINAETDISKIFGTKQICINRCIKCQEEKIKESILLACNLSYPNHIKDSDQYFNFGTIL 724
            .|.:.|..:...:..:||             .|....|:.::.|:.  |:.: .::...|...:|
Zfish   610 SDLDLSDTDPMEECYRIF-------------MEANQSEAPVVQCDA--PDKV-GTEMKSNPVALL 658

  Fly   725 KRSLSSEKSIQAFCERCKKFSPTNQS--------------VKVTSLPQILSINCGLNNEKDITFL 775
            |:.::          ...||.|.::|              :.|.|..|:    |    ::....|
Zfish   659 KKRVA----------HVAKFEPASKSKAQIIVPLQEGTSHLNVPSRSQL----C----QRRAAIL 705

  Fly   776 KRQLNRCSEKTTVDAAASLSTSKPCRYGANCSRSDC----------------HFM---------- 814
            ...:..|..:....|...:.||...:...:..::.|                ||:
Zfish   706 TAAVKGCQSQVINSAPKKVYTSNVHQIHQSAVQNSCVGIIPVGATLQLGTNLHFIVPEGNCALPL 770

  Fly   815 ----------HPDRKSP-------SHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEVQVQTQS 862
                      .|.:.||       .|.:||  .|.:|..||                .:.:.||.
Zfish   771 TLIPTTMSVQRPPQPSPPVQLAPAQHPTQP--ANYTPAKRQ----------------AICLSTQD 817

  Fly   863 DASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYHTMKLAESADD 927
                  |.|:......|::..::    |||         :|.|::.:....:.:|.:......|.
Zfish   818 ------STQQRFKYHRPSEAQNS----ALH---------SQPNVMGVKRKAKVHHEVGAKVPHDV 863

  Fly   928 PQSQWYIF-NDFSISPVSPQESVWFTLDWKVPCILFYRHVED-DSESASTTSSTVTESEETIPSE 990
            .|....:| .:|..|.|:.|::  |........|::.|.:.. ...|.:..:....:::..:|::
Zfish   864 RQRYVNLFVEEFLKSSVTVQDA--FEKALAEEKIVYDRSINKLKYLSIAVNALKRLKNQNILPAK 926

  Fly   991 SSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDLV--------AMDAEFVTLN- 1046
            :.|....::|.           ||:       ||.:..:...|||.        .:..:.:.:|
Zfish   927 APSERDQHVSR-----------GNV-------PLNTQALQGPGDLTLFEQLKEHILSEDLLQVNN 973

  Fly  1047 -PEENEIRPD--------------------------------GKTATIKPCHMSVARI------- 1071
             |.:::.:.|                                ||....:.|:....::
Zfish   974 FPRKHQDKADFAIQYGDTKKGISDPLKRICCRCGATFSVDRSGKHTRREECNYHYGKVIENRVPG 1038

  Fly  1072 ------SCIRGQGPAEGVP---------------------------------------------- 1084
                  ||...   |.|.|
Zfish  1039 GVETRYSCCEN---AVGSPGCQVFNLHVHDAVSLQGFVSSLHQSAVGKTCPGIYAIDTQTCYTTQ 1100

  Fly  1085 ----------------FMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKR-LTALKYSYQKLKY 1132
                            ..|.::.....|:||.|:||||...|:.::.|..| :.|:..|:
Zfish  1101 GLELARVTVVSSSLQVVFDSFVKPDNDVIDYNTRFSGISEADVKSSSSSLRDVQAVLLSF----- 1160

  Fly  1133 LVDVGVIFVGHGLKNDFRVINIYVPSEQIIDT----VHLFHMPHHRMVSLRFLAWHFLGTKIQS- 1192
             ::...|.:||||:||...:.|.  ...::||    .|...:||.|  .|..|...:|...||.
Zfish  1161 -INADTILIGHGLENDLAALKII--HSTVVDTSVVFPHRLGLPHKR--ELNSLTADYLRRIIQES 1220

  Fly  1193 -ETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQLQWKVPED 1241
             |.||:.|||...::|                          :.|:|.||
Zfish  1221 VEGHDTREDATACMEL--------------------------MLWRVKED 1244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:475233	40/246 (16%)
		WD40 repeat	148..183	CDD:293791	6/53 (11%)
		WD40 repeat	187..221	CDD:293791	8/45 (18%)
		WD40 repeat	227..273	CDD:293791	4/45 (9%)
		WD40 repeat	278..314	CDD:293791	7/40 (18%)
		UCH_1	505..940	CDD:463872	85/526 (16%)
		zf-CCCH_2	799..816	CDD:464217	3/52 (6%)
		PAN2_exo	1036..1209	CDD:99846	51/296 (17%)
zgc:152968	NP_001314684.2	None