DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and rexo1

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001119888.1	Gene:	rexo1 / 564551	ZFINID:	ZDB-GENE-030131-1650	Length:	1207	Species:	Danio rerio

Alignment Length:	1176	Identity:	207/1176 - (17%)
Similarity:	356/1176 - (30%)	Gaps:	456/1176 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 HRP-----KTIDPEVLSNMKMQGPIGYSPNPRTARRNQIPYVIEQGGVCSPNGNGTA-----AAT 466
            |:|     :..||   .:.:|.....|:|:|.:::     |.::     :.|.|..|     .|.
Zfish   137 HKPPVPSHEGYDP---GSYQMDQASEYTPSPHSSK-----YTLD-----TENTNANALEYVPTAV 188

  Fly   467 KAENGVKIIPRRYRKVELKY---TKLGTQDFDFD------------QHNQTCFAG---------- 506
            ...|..|:.||.....:.||   |...|.|.::|            :......||
Zfish   189 SKSNIKKLTPRPPSHAKCKYTLDTSKPTTDMEYDPLSNYSAKPTIKEQKTLALAGQRRKRLYSEK 253

  Fly   507 ---LEATLP------NSYCNAML--QILYFTDA-----------LRVKLLEHSCIK-EFCLSCEL 548
               .|..:|      :|:..|.:  ....|:::           :.|..|:|:.|. ....|..:
Zfish   254 QGEAEEYVPTVKKPKSSFTKADVPKYTASFSESDEESSGTEYRPVNVSRLKHNRINIGLPKSSAM 318

  Fly   549 GFLFNMLDKSTA-SSPCQASNF------LRSFRTVPEASALGLILTDRSSNVNLISLIQNWNRFI 606
            |.....:.|:.| .|||::.:.      ..:.:|..:.||       ..:..|....::..|:..
Zfish   319 GQQKKQISKTDAYFSPCESDDTESQDVNRTNKKTDKKVSA-------SQTKTNKTDKVKKENKDS 376

  Fly   607 LHQMHYEIFDSSK-NASTYSGSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAE 670
            ..:...|..|||. :.::.|.|.:.::.::|...|..|......|..:.::::|.|::..||..|
Zfish   377 NKKSQKEQQDSSSVDKTSKSSSKKDNSQSKNIEGSSKSKEKSHKDKSASKSAEEKDKKVVKIKTE 441

  Fly   671 -----------------------TD--ISKIFGTKQICINRCIKCQE----------EKIKESIL 700
                                   ||  :|||...|...:....|.::          :|.|:||.
Zfish   442 SSHKEKNKSSDGIKKPKMDKPVKTDKVLSKIKDQKNGKLESGSKEKDKKKSSSSNTKDKSKKSIS 506

  Fly   701 L----------ACNLSY----------------PNHIKDSDQYFNFGTILKRSLSSEKSIQAFCE 739
            :          ..|||:                ...::.|...|..|.::.....|..|.:...|
Zfish   507 VLDHKEAKKTKQRNLSHVDLFGADSAEEEDEEDERIVRKSASAFKRGGLVNNKRKSSSSSEDDSE 571

  Fly   740 --------RCKKFSPTNQSVKVTSLP--QILSINCGLNNEKDITF-----LKRQLNRCSEKTTVD 789
                    ..:.||.....::..|.|  :.|.|   .|..|::..     ..:|.:|.:|:...:
Zfish   572 VDEDDGGVDTEDFSCLQDVMEYDSDPMEECLRI---FNESKEVKMEDKGRQAKQPSRETEEEDEE 633

  Fly   790 AAASLST-----------------------SKPCRYGANCSRSDCHFMHPDRK------------ 819
            ..::|:|                       |.|.:.....::..|:......:
Zfish   634 TESTLTTLFPGQKKRVSHFKAQGKSETTMNSVPMQQRRMTAQEICYQRMQKAQQQAAQLAEAVKT 698

  Fly   820 -SPSHTSQP--------NAVNNSPNGRQKSWFP-------LTFTMGINDQGEVQVQTQSDASS-- 866
             |.|.:|.|        ..|.:.||....|..|       |:.|..:.||..|:.||.:...|
Zfish   699 ASASASSNPVLGISGEKRRVAHRPNASLPSSKPADASSRVLSPTRVVTDQLSVKAQTSAGILSKT 763

  Fly   867 -GKSEQEEETEKPPTKGLDNNR--------------------------------------MYALH 892
             ..:.|:.....|..|.....|                                      ..||.
Zfish   764 ISTTVQKRVAHTPTLKSSTMKRPVIPTEFGAKVPTIVRQRYLNIFIDECLKFCSSEQDAFQLALE 828

  Fly   893 AVVCQVDDGTQKNLVSLINVQRPYHTMKLAESADDPQSQWYIFNDFSISPVSPQESVWFTLDWKV 957
            ......|..:.||:  .:||  ..:|:|...|...|           .|||:           |.
Zfish   829 EEKVVYDRSSSKNI--YLNV--AVNTVKKLRSRSTP-----------ASPVT-----------KS 867

  Fly   958 PCILFYRHVEDDSE-----SASTTSSTVTES-----------------------EE-------TI 987
            |.:...:..:...|     .|:|||.|:..|                       ||       .:
Zfish   868 PAVSVNKKAQSHEEVLGGRLAATTSFTINRSGKQHDVNPKGAILYKKLRKYAMTEEQLQEHGYPL 932

  Fly   988 PSESSSGSPT--NL-----SNPF------------------------------------------ 1003
            |....||...  ||     ::||
Zfish   933 PHPEISGHAVVHNLPEKKNNDPFSKICCRCGAEYKVNSNGSCVRKEECSHHWGRLRRNRVPGGWE 997

  Fly  1004 -LEEIVSPMLGNLSADATLQPLQ--------------SDEMPQSGD--LVAMDAEFVTLNPEENE 1051
             |....|..:|:...:...|.:|              |..:|..|:  :.|:|.|.
Zfish   998 TLYNCCSGAVGSPGCEVCKQHVQDGRKESLDGFVKTFSKPLPVDGNAGVYALDCEM--------- 1053

  Fly  1052 IRPDGKTATIKPCH----MSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLD 1112
                        |:    :.:.|::.|.    :|.....|.::....:||||.|:|||:...||:
Zfish  1054 ------------CYTKQGLELTRVTVIN----SELKVVYDTFVKPGSRVVDYNTRFSGVTADDLE 1102

  Fly  1113 -ANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTV----HLFHMPH 1172
             ...|.:.:.|:..|      :.....|.:||.|::|...:.:.  ...::||.    |...:|:
Zfish  1103 NTTISLRDVQAVLLS------MFSADSILIGHSLESDLFALKLI--HSMVVDTAIVFPHRLGLPY 1159

  Fly  1173 HRMVSLRFLAWHFLGTKIQSET--HDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQLQ 1235
            .|  :||.|...:|...||...  |||.||||..::|                          :.
Zfish  1160 KR--ALRNLMADYLKRIIQDNVGGHDSSEDARACMEL--------------------------MI 1196

  Fly  1236 WKVPED 1241
            ||:.||
Zfish  1197 WKIKED 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	106/643 (16%)
		zf-CCCH_2	799..816	CDD:317060	2/16 (13%)
		PAN2_exo	1036..1209	CDD:99846	45/183 (25%)
rexo1	NP_001119888.1	EloA-BP1	785..948	CDD:292495	31/188 (16%)
		REX1_like	1047..1195	CDD:99848	45/208 (22%)
		DnaQ	1060..>1196	CDD:223916	41/175 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810