DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and isg20l2

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001096663.1	Gene:	isg20l2 / 558447	ZFINID:	ZDB-GENE-070928-8	Length:	321	Species:	Danio rerio

Alignment Length:	257	Identity:	71/257 - (27%)
Similarity:	107/257 - (41%)	Gaps:	44/257 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   991 SSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDLVAMDAEFVTLNPEENEIRPD 1055
            |||....:.::.:|    .|...|:|.....|.:.....|.....:|:|.|.|...|
Zfish    96 SSSAQAYSRTSTYL----FPSHANISQRDLTQRMAVPRPPGPIKYLALDCEMVGTGP-------- 148

  Fly  1056 GKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRL 1120
                  |.....:||.|.:...|..    ..|.|:.....|.||.|::|||:..||        |
Zfish   149 ------KGAQSELARCSIVSYDGDV----VYDKYVKPINPVTDYRTRWSGIRRQDL--------L 195

  Fly  1121 TALKYSYQKLKYLVDV--GVIFVGHGLKNDFRVINIYVPSEQIIDT--VHLFH----MPHHRMVS 1177
            .|..: |...|.:|.:  |.:.|||.:.|||:.:..:.|:.|..||  :.|.:    .|..:.||
Zfish   196 HATPF-YHAQKEIVKIITGKVVVGHAIHNDFKALKYFHPAFQTRDTSRIPLLNEKAGFPEKQCVS 259

  Fly  1178 LRFLAWHFLGTKIQS--ETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQLQWK 1237
            |:.|....|...||:  ..|.|:|||:.|::|||...::.|:|.   |..||..:...|..|
Zfish   260 LKKLTQAILKRDIQTGYRGHSSVEDAKATMELYKVVERMWEQKL---ASLNLSAKAMDLAMK 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	53/182 (29%)
isg20l2	NP_001096663.1	DnaQ	133..>293	CDD:223916	53/186 (28%)
isg20l2	NP_001096663.1	ISG20	137..293	CDD:99852	53/182 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910