DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and rexo4

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001006868.1	Gene:	rexo4 / 448635	XenbaseID:	XB-GENE-6258946	Length:	414	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	100/436 - (22%)
Similarity:	158/436 - (36%)	Gaps:	113/436 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 QVQTQSDASSGK-SEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYHTMK 920
            |.|:.|.::.|| :..:::|:|...|     :.:..|..:.. .....|.|..|:..::|
Frog     8 QDQSPSGSALGKAANSQKQTKKQKKK-----KFWKNHPKIAG-KTSEAKTLFPLLPPKQP----- 61

  Fly   921 LAESADDPQSQWYIFNDF------SISPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTS-- 977
                 .:..|.|....:.      ..:|.:|.|. :...|.||.     .....|.|...:|.
Frog    62 -----QEFSSNWKALQELLKPKLNPAAPATPSEK-FPKKDQKVS-----EKKNGDPEPPKSTPKI 115

  Fly   978 ----STVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSG----- 1033
                ::||..|...||::   .||.     ..|:.......:.|:.|.| |...:.||.|
Frog   116 NGGITSVTPKEAKAPSQA---PPTK-----AVEVKKEKKRKIKAEGTEQ-LDPPKKPQGGTQPEP 171

  Fly  1034 -------DLVAMDAEFVTLNPEENEIRPD--GKTATIKP----------------------CHM- 1066
                   |.|..|.....|.||...|..:  |.|.|..|                      |.|
Frog   172 PKVDIWFDDVDPDDIEAALGPEAGRIAREMQGVTETAPPTAEKVLVKEKAFEGLTRTVAMDCEMV 236

  Fly  1067 ---------SVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRLTA 1122
                     .:||:|.:...|..    ..|.|:...|:|.||.|..|||:|.|:      |...|
Frog   237 GVGLDGEESMLARVSIVNLFGKC----VYDKYVRPTERVTDYRTAVSGIRPDDI------KNGEA 291

  Fly  1123 LKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMV-----SLRFLA 1182
            .|....::..::. |...|||.:.||.:::.:..|.:.|.||..  :.|....|     ||:.|.
Frog   292 FKDVQAEVAEILR-GRTLVGHAVHNDLKILFLDHPKKAIRDTQK--YKPFKEKVKSGRPSLKLLC 353

  Fly  1183 WHFLGTKIQSETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLY 1228
            ...|..|:|:..|.|::||:..::||     ..|:|.:..|:|..|
Frog   354 EKILNVKVQTGEHCSVQDAQAAMRLY-----TMEKKCWEAAIKAKY 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	15/89 (17%)
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	54/211 (26%)
rexo4	NP_001006868.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174		39/196 (20%)
rexo4	NP_001006868.1	REX4_like	229..380	CDD:99847	45/168 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910