DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and CG12877

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001034073.1	Gene:	CG12877 / 43333	FlyBaseID:	FBgn0039544	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	839	Identity:	160/839 - (19%)
Similarity:	259/839 - (30%)	Gaps:	318/839 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 KSTASSPCQASNFLRSFRTVPEASALGLILTDRSSNVNLISLIQNWNRFILHQMHYEIFDSSKNA 621
            ||::||....|:..:|      :|:.....|.|||:                        |||:|
  Fly   285 KSSSSSSSSKSHHHKS------SSSSSRSKTKRSSS------------------------SSKSA 319

  Fly   622 STYSGSVQTSTNAENAGSSETSGSSDLYD-------------------SISDENSK--------- 658
            .|.....:...:.|.|..:......||.|                   .|.||..|
  Fly   320 GTSKSEPEADKDTEAAVLTPAEPMDDLDDMDFDFEADTSEGEIVRQCEMIFDEMEKKFAQMHKDE 384

  Fly   659 ------EDDRERSKINAETDISKIFGTKQICINRCIKCQEEKIKESILLACNLSYPNHIKDSDQ- 716
                  |..|:|...:.:.|......|..:...|......:||...:..:..:..|||::::.|
  Fly   385 GGNANPESSRKRKAPSPDIDTFTEAATAALQKRRVAHENADKITPHLAPSAAMRKPNHVRNAMQA 449

  Fly   717 YFNFGTILKR--SLSSEKS---IQAFCERCKKFSPTNQSVKVTS-----------LPQILSINC- 764
            .||....|:|  .|.:|.|   ::...||.::.....:..||.|           .|.:.|...
  Fly   450 IFNRRAELRRQEKLQAEASAEQVRQAQERVRQAQEELRQAKVNSNLTPLISRSALTPPVRSARSI 514

  Fly   765 -----------------GLNNEKDITFLKRQ----LNRCSEKTT--VDAAASLSTS-KPCRYGAN 805
                             .|..||...|...|    ..|.:.|.|  :|.||.:|.: ||.....:
  Fly   515 APVANIVAIARAKKKIEELQAEKKPAFTPAQSFKGAGRVAHKPTAALDKAAPVSNAEKPTVLDPS 579

  Fly   806 CSR--------------SDCHFMHPDRKSPSHTSQPN--------------------AVN----- 831
            .|:              ..|..::|........:|..                    |:|
  Fly   580 SSKISYNVRIQYYEMMVRHCTVIYPQLADAWERAQVEELTVFKKCNTPAIYKNSCMLAINKLRKE 644

  Fly   832 -----NSPN------------GRQKSWFPLTFTMGINDQGEVQVQTQSDASSGKSEQEEETEKPP 879
                 |.|:            |.:::   ||.:..:..:|::       :|.|..|        |
  Fly   645 ALEAGNKPSVACKTVSHEMMLGGKRA---LTTSWSVEKKGKL-------SSLGNGE--------P 691

  Fly   880 TKGLDNNRMYALHAVVCQVDD--GTQKNLV-------------SLINVQRPYHTMKLAE------ 923
            ...||..:.|.:      |.|  .|::.||             ::|...||.......|
  Fly   692 FDALDAEKAYKM------VFDLRLTEEQLVENGYPRPGDKRGSAVIRACRPNRRPNQKERYCSRC 750

  Fly   924 ----SADDPQSQWYIFNDFSISPVSPQESVW---FTLDWK---------VP-CILFYRHVED--D 969
                |.|     .|....|.:....|:.:.:   || |.:         .| |.....||.|  |
  Fly   751 GKVFSLD-----IYEHQSFDMCNYHPKSTGYRRGFT-DHQHRCCQQPAGTPGCTYANYHVSDYYD 809

  Fly   970 SESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGD 1034
            .|..:....|:...||.:|::.                                          |
  Fly   810 PEKLTCFVKTIERGEEFVPTKK------------------------------------------D 832

  Fly  1035 LVAMDAEFVTLNPEENEIRPDGKTATIKPCH----MSVARISCIRGQGPAEGVPFMDDYISTQEK 1095
            :.|:|.|.                     |:    :.:.|::.:    ...|....|..:....:
  Fly   833 IYALDCEM---------------------CYTTHGIELTRVTVV----DINGRSVYDALVKPDNQ 872

  Fly  1096 VVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQ 1160
            :|||.|.:|||    .:|..|.:..| ::.....|..:.....:.|||.|::|.:.:.:.  .:.
  Fly   873 IVDYNTTYSGI----TEAMLSNETRT-IRDVQAVLMSMFHAKTVLVGHSLESDLKALKLI--HDV 930

  Fly  1161 IIDTVHLFHMPHH----RMVSLRFLAWHFLGTKIQ-SET-HDSIEDARTTLQLYKHYLK 1213
            ::||..||  ||.    :..:|:.|....|...|| ||. |||.|||...:||.|:||:
  Fly   931 VVDTSVLF--PHKMGPPKKRALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIKYYLR 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	97/539 (18%)
		zf-CCCH_2	799..816	CDD:317060	3/30 (10%)
		PAN2_exo	1036..1209	CDD:99846	44/182 (24%)
CG12877	NP_001034073.1	CDC45	129..>199	CDD:280821
		EloA-BP1	572..736	CDD:292495	27/187 (14%)
		REX1_like	834..983	CDD:99848	44/182 (24%)
		DnaQ	847..>991	CDD:223916	43/154 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810