Protein Alignment PAN2 and Pan2

DIOPT Version :10

• Sequence 1: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_001382635.1
• Gene: Pan2 / 408200
• RGDID: 1303301
• Length: 1207
• Species: Rattus norvegicus
• Alignment Length: 1304
• Identity: 525/1304 - (40%)
• Similarity: 724/1304 - (55%)
• Gaps: 207/1304 - (15%)

  Fly    24 GSAPGNGHFSPSFNGF---------------NIGTTDPE-------------------YVELVPV 54
            |..||...|||:.:..               |: ..|||                   |.||..|
  Rat     5 GLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNV-ELDPEGVALEALPVQESVHIMEGVYSELHSV 68

  Fly    55 LADGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGVLA 119
            :|:.|....||.  ||..||:||:|:.|||.||::..::::|:||||:.:|.:|.|.:|::|:|.
  Rat    69 VAEVGVPVSVSH--FDLQEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIRQIQSLENGILF 131

  Fly   120 LTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGLQDELIDFDLRTLKETRIEHVGA 184
            ||:.:|::..|.||..|.:..:..::|.|:|....:.|::.|||:.:::.||.|::||:...|..
  Rat   132 LTKNNLKYMARGGLIIFDYLLDESEDMHSLLLADNNTLLVGGLQNHVLEIDLNTVQETQKYAVET 196

  Fly   185 GGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGRQNNL 249
            .|.|::|:.:|:.|.|...|.|:||||.|..|:|.....:..||||.|.||||.:||:|.|...|
  Rat   197 PGVTIMRQTNRFFFCGHTSGKVSLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGL 261

  Fly   250 AIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSMYQ 314
            |.||||.||||||:|.|.|:||.:||..|:|:|:.||:||::|..||.|..:...|:.| ..::.
  Rat   262 ACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANP-ADIFH 325

  Fly   315 INTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFA--DVVPQLPMVSI 377
            :|..|...::||:|:|.||:||||..|.:::  ...:|:|.||.|||.||||  .:|..||.:..
  Rat   326 VNPVGPLLMTFDVSASKQALAFGDSEGCVHL--WTDSPEPSFNPYSRETEFALPCLVDSLPALDW 388

  Fly   378 TDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGYSPNPRTARR 442
            :....|||.:.:| |||.. ..||||.........|...:|.|:|..||..|.|||:|||||..|
  Rat   389 SQDLLPLSLIPVP-LTTDA-LLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLR 451

  Fly   443 NQIPYVIEQGG---------VCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDFDQ 498
            |||||.:::..         ..||.|       :.|..:..:.::||||.:||:|||.:||||..
  Rat   452 NQIPYRLKESDHEFDNFSQVTESPTG-------REEEPLHTVSKKYRKVTIKYSKLGLEDFDFKH 509

  Fly   499 HNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTASSP 563
            :|:|.|||||..:||:|||.|:|:|||.:.:|..:..|.|.|||||:|||||||:|||.| ...|
  Rat   510 YNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLS-RGDP 573

  Fly   564 CQASNFLRSFRTVPEASALGLILTD---RSSNVNLISLIQNWNRFILHQMHYEIFDSSKNASTYS 625
            ||.|||||:|||:||||||||||.|   .|...:|..|||.||||||.|:|.:: ...:....|.
  Rat   574 CQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDM-QELEVPQAYR 637

  Fly   626 GSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAETDISKIFGTKQICINRCIKC 690
            |          ||.|....|.   |||                    |.::|..:....:.| :|
  Rat   638 G----------AGGSSFCSSG---DSI--------------------IGQLFSCEMENCSLC-RC 668

  Fly   691 QEEKIKESILLACNLSYP-NHIKD-SDQYFNFGTILKRSLSSEKSIQAFCERCKKFSPTNQSVKV 753
            ..|.::.|..|...|||| ..|.| :.:.::|..:||||:..|::.||:|:.|:|:.||.|:..:
  Rat   669 GSETVRASSTLLFTLSYPEGSICDKTGKNYDFAQVLKRSICLEQNTQAWCDSCEKYQPTIQTRNI 733

  Fly   754 TSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLSTSKPCRYGANCSRSDCHFMHPDR 818
            ..||.||.|||.:|:.|:..|.:.|         .:.|..::..|   :|......:  |...||
  Rat   734 RHLPDILVINCEVNSSKEADFWRLQ---------AEVAFKIAVKK---FGGEVKSKE--FALADR 784

  Fly   819 KSPSHTSQPNAVNNSPNG---------RQKSWFPLTFTM------GIN-----DQGEV-QVQTQS 862
            |.          ..||.|         .:..|.|.:..|      |::     |:.|: .:.|.|
  Rat   785 KE----------LRSPEGFLCCSSMEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGTPS 839

  Fly   863 DASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQV-DDGTQKNLVSLINVQRPYHTMKLAESAD 926
            .....::|:|...           .:|.|.|.|..: |..|..:||:.|.|...||..|...:
  Rat   840 QWGPARAEEEHGV-----------YVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVT-- 891

  Fly   927 DPQSQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTSSTVTESEETIPSES 991
              ..|||:||||.|.|:...|:|.|.::||||.||:|                       :....
  Rat   892 --HQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYY-----------------------VKRNL 931

  Fly   992 SSGSPTNLSNPFLEEIVSPMLGNLSADATLQ-----------PLQSDEMPQSGDLVAMDAEFVTL 1045
            :|....|:.||....:       |.|:|:|.           ||..:||||.||||.:|||||||
  Rat   932 NSRYNLNIKNPIEASV-------LLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTL 989

  Fly  1046 NPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGD 1110
            |.||.|:|.||..:||||..||||||:|:|||||.||:||:||||||||:|||||||:|||||||
  Rat   990 NEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGD 1054

  Fly  1111 LDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRM 1175
            |||..|.|.||.||.:|.||::|:|:||.||||||:.||||||:.||.:|::|||:|||||..||
  Rat  1055 LDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRM 1119

  Fly  1176 VSLRFLAWHFLGTKIQSETHDSIEDARTTLQLYKHYLKLQ----EEKKFANALKNLYERGKQLQW 1236
            :|||||||:||..|||.|||||||||||.||||:.||:|.    |.:.|...||.|||:|:::.|
  Rat  1120 ISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGAEPESFHKVLKGLYEKGRKMDW 1184

  Fly  1237 KVPE 1240
            ||||
  Rat  1185 KVPE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:475233	88/206 (43%)
		WD40 repeat	148..183	CDD:293791	11/34 (32%)
		WD40 repeat	187..221	CDD:293791	14/33 (42%)
		WD40 repeat	227..273	CDD:293791	30/45 (67%)
		WD40 repeat	278..314	CDD:293791	13/35 (37%)
		UCH_1	505..940	CDD:463872	155/461 (34%)
		zf-CCCH_2	799..816	CDD:464217	2/16 (13%)
		PAN2_exo	1036..1209	CDD:99846	124/172 (72%)
Pan2	NP_001382635.1	WD40	75..357	CDD:475233	118/286 (41%)
		WD 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	153..193		12/39 (31%)
		WD 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	195..231		14/35 (40%)
		WD 3. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	244..280		23/35 (66%)
		WD 4. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	328..367		15/40 (38%)
		Linker. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	368..484		46/124 (37%)
		UCH_1	516..903	CDD:463872	155/461 (34%)
		PAN2_exo	980..1153	CDD:99846	124/172 (72%)