DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and ISG20

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001290162.1	Gene:	ISG20 / 3669	HGNCID:	6130	Length:	181	Species:	Homo sapiens

Alignment Length:	191	Identity:	61/191 - (31%)
Similarity:	85/191 - (44%)	Gaps:	38/191 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1029 MPQSGDLVAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQ 1093
            |..|.::||||.|.|.|.|.    |..|           :||.|.:.    ..|....|.:|..:
Human     1 MAGSREVVAMDCEMVGLGPH----RESG-----------LARCSLVN----VHGAVLYDKFIRPE 46

  Fly  1094 EKVVDYLTQFSGIKPGDL--DANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYV 1156
            .::.||.|:.||:.|..:  ...|:..||..|    |.||     |.:.|||.||:||:.:...:
Human    47 GEITDYRTRVSGVTPQHMVGATPFAVARLEIL----QLLK-----GKLVVGHDLKHDFQALKEDM 102

  Fly  1157 PSEQIIDTV------HLFHMPHHRMVSLRFLAWHFLGTKIQSET--HDSIEDARTTLQLYK 1209
            ....|.||.      ....:.|.|.||||.|:...|...||:..  |.|:||||.|::||:
Human   103 SGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQ 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	58/182 (32%)
ISG20	NP_001290162.1	DnaQ_like_exo	8..163	CDD:415823	58/182 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810