DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and Isg20l2

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001007742.1	Gene:	Isg20l2 / 361977	RGDID:	1359413	Length:	369	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	85/396 - (21%)
Similarity:	141/396 - (35%)	Gaps:	113/396 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 INDQGEVQVQTQSDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQR 914
            :..:|.:..:.|..:...|...|     ||.|| :.:|:           |...|.|..|...:.
  Rat    34 LEQKGFLSKKNQPPSKVSKLNSE-----PPKKG-ETSRV-----------DSISKILSCLKKKKE 81

  Fly   915 PYHTMKLAESADDPQSQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTSST 979
            ...:.:.:|.:.|.::                     :|.|..|.            .:..|.|.
  Rat    82 AAASKRDSEQSKDKKA---------------------SLSWLTPA------------PSKKTDSV 113

  Fly   980 VT------ESEETIPSESSSGSPTNLSNPFLEEIVS----------------PMLGNLSADAT-L 1021
            |.      |.:..:|.............|..::|.:                |:..|...::| .
  Rat   114 VAKIDLLGEFQSALPKPKRRTQKKGSKKPLKKKIATENSTQTQSKDKGSNKKPLKKNAVQNSTQA 178

  Fly  1022 QPL-QSDEMPQS--GDLVAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGV 1083
            ||. :..::|||  ..:||:|.|.|...|:       |:.:       |:||.|.:...|..
  Rat   179 QPEDKCPKVPQSLPRKMVAIDCEMVGTGPK-------GRVS-------SLARCSIVNYNGDV--- 226

  Fly  1084 PFMDDYISTQEKVVDYLTQFSGIKPGDL--DANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLK 1146
             ..|:||.....:|||.|::|||:...:  ...|...|...||         :..|.:.|||.:.
  Rat   227 -LYDEYIRPPCYIVDYRTRWSGIRKCHMVNATPFKTARSQILK---------ILSGKVVVGHAIH 281

  Fly  1147 NDFRVINIYVPSEQIIDTVHL------FHMPHHRMVSLRFLAWHFLGTKIQS--ETHDSIEDART 1203
            ||::.:..:.|.....||..:      ...|.:..:||:.|....|...||:  ..|.|:|||:.
  Rat   282 NDYKALQYFHPKSLTRDTSQIPLLNRKADCPENVTLSLKHLTKKLLSRDIQTGLSGHSSVEDAQA 346

  Fly  1204 TLQLYK 1209
            ||:|||
  Rat   347 TLELYK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	15/89 (17%)
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	50/182 (27%)
Isg20l2	NP_001007742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..68		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..107		5/59 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..188		8/62 (13%)
		ISG20	196..352	CDD:99852	50/182 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810