DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and Rexo1

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001012114.2	Gene:	Rexo1 / 314630	RGDID:	1309872	Length:	1197	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	107/528 - (20%)
Similarity:	175/528 - (33%)	Gaps:	167/528 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 EKSIQAFCERCKKFSPTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLS 795
            ::.:..|.|.|.||..:||.          :|...||.|| :.:.:      |....:....:::
  Rat   795 QRYLNLFIEECLKFCSSNQE----------AIEKALNEEK-VAYDR------SPSKNIYLNVAVN 842

  Fly   796 TSKPCRYGANCSRSDCHFMHPDRKSPSHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEVQVQT 860
            |.|..|                      ...||||.|......:........:|    |::..:|
  Rat   843 TLKKLR----------------------GLVPNAVPNLSKASSRRVVSHEVVLG----GKLAAKT 881

  Fly   861 QSDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYHTMKLAESA 925
            ....|...|.:.||        |....:|:                             :|.|..
  Rat   882 SFSLSRPSSPRVEE--------LKGTALYS-----------------------------RLREYL 909

  Fly   926 DDPQ---SQWYIFNDFSISPVSPQESVWFTLDWKVP----CILFYRHVEDDSESASTTSSTVTES 983
            ..|:   ...|.|.    .|..|..:|.||.:.|.|    |.:..|   ..:|...::|.....:
  Rat   910 LTPEQLKENGYPFP----HPERPGGAVIFTAEEKKPKDPSCRICCR---CGTEYLVSSSGRCVRN 967

  Fly   984 EETI-------PSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQ--------------SD 1027
            ||..       .:..:.|..|...      ..|..:|::......|.:|              ..
  Rat   968 EECYYHWGRLRRNRVAGGWETQYM------CCSAAVGSVGCQVAKQHVQDGRKENLEGFVRTFQK 1026

  Fly  1028 EMPQS--GDLVAMDAE--FVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDD 1088
            |:|:.  ..:.|:|.|  :.|...|...:       |:....|.|.                .|.
  Rat  1027 ELPEDAHAGVFALDCEMSYTTYGLELTRV-------TVVDTDMQVV----------------YDT 1068

  Fly  1089 YISTQEKVVDYLTQFSGIKPGDL-DANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVI 1152
            ::.....||||.|:|||:...|| |.:.:.:.:.|:..|      :.....|.:||.|::|  ::
  Rat  1069 FVKPDNAVVDYNTRFSGVTEADLVDTSITLRDVQAVLLS------MFSADTILIGHSLESD--LL 1125

  Fly  1153 NIYVPSEQIIDTVHLF-H---MPHHRMVSLRFLAWHFLGTKIQS--ETHDSIEDARTTLQLYKHY 1211
            .:.|....::||..|| |   :|:.|  |||.|...:|...||.  :.|.|.|||...:.|.  .
  Rat  1126 ALKVIHGTVVDTSVLFPHRLGLPYKR--SLRNLMADYLRQIIQDNVDGHSSSEDASACMHLV--I 1186

  Fly  1212 LKLQEEKK 1219
            .|::|:.|
  Rat  1187 WKIREDAK 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	35/211 (17%)
		zf-CCCH_2	799..816	CDD:317060	1/16 (6%)
		PAN2_exo	1036..1209	CDD:99846	48/181 (27%)
Rexo1	NP_001012114.2	EloA-BP1	778..938	CDD:292495	40/226 (18%)
Rexo1	NP_001012114.2	REX1_like	1037..1185	CDD:99848	47/180 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810