DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and Rexo4

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001029056.1	Gene:	Rexo4 / 311826	RGDID:	1306220	Length:	409	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	100/490 - (20%)
Similarity:	166/490 - (33%)	Gaps:	183/490 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   732 KSIQAFCERCKKFSPTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLST 796
            |::|...:| |..:|..        |:|..::..::::    .:::...:.|:|:..|...  ..
  Rat    62 KALQELLKR-KSEAPEK--------PRISQLDDKIHHQ----IIQKNRKKTSDKSKGDKRT--ED 111

  Fly   797 SKPCRYGANCSRSDCHFMHPDRKSPSHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEVQVQTQ 861
            .||.|                   .|.||.|..|..:|       .|.|...|...:...:.:|:
  Rat   112 DKPTR-------------------DSVTSAPKKVRKTP-------VPPTNASGTEQKKGAEKRTR 150

  Fly   862 SDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYHTMKLAESAD 926
            ||.||.:.:.:.:                          |..|....:::
  Rat   151 SDLSSHQGDIKHK--------------------------GKAKEAAVILS--------------- 174

  Fly   927 DPQSQWYIFNDFSISPVSPQESVWF-TLDWKVPCILFYRHVEDDSESASTTSSTVTESEETIPSE 990
                          .|...:|.:|| .:|            .||.|:|
  Rat   175 --------------QPTPTEEDIWFDDVD------------PDDIEAA----------------- 196

  Fly   991 SSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDL---VAMDAEFVTLNPEENEI 1052
                     ..|....:|...||..::..:|...|:     .|.|   :|:|.|.|.:.|:..|
  Rat   197 ---------VGPEAAMLVRKRLGQRTSTISLVKEQA-----FGGLTKALALDCEMVGVGPKGEE- 246

  Fly  1053 RPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDL----DA 1113
                         ...||:|.:...|..    ..|.|:...|.|.||.|..|||:|.:|    :.
  Rat   247 -------------SIAARVSIVNQYGKC----VYDKYVKPTEPVTDYRTAVSGIRPENLKQGEEF 294

  Fly  1114 NFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMV-- 1176
            ...||.:.|:      ||     |.|.|||.|:||.:|:.:..|.::|.||...  .|...:|
  Rat   295 EVVKKEVAAM------LK-----GRILVGHALRNDLKVLFLEHPKKKIRDTQKF--KPFRSLVKS 346

  Fly  1177 ---SLRFLAWHFLGTKIQSETHDSIEDARTTLQLY 1208
               ||:.|:...||.::|...|.|::||:..::||
  Rat   347 ARPSLKQLSEKILGLRVQQAEHCSVQDAQAAMRLY 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	29/207 (14%)
		zf-CCCH_2	799..816	CDD:317060	2/16 (13%)
		PAN2_exo	1036..1209	CDD:99846	54/182 (30%)
Rexo4	NP_001029056.1	DnaQ	228..>392	CDD:223916	54/185 (29%)
Rexo4	NP_001029056.1	REX4_like	231..381	CDD:99847	52/180 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810