DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and prage

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	135/705 - (19%)
Similarity:	227/705 - (32%)	Gaps:	235/705 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 SSKNASTYSGSVQTSTNAEN-------AGSSETSGS----SDLYDSISDENSKEDDRERSKINAE 670
            :|.::...|..:.:|:...|       |||...||.    |..:...|.:.::..|....:..|.
  Fly   252 NSTSSDATSEDIDSSSELPNKSKGNSCAGSIHASGGSKSRSKRHQKQSGQQTRNPDHNGQRTGAA 316

  Fly   671 TDISKIFGTKQICINRCIKCQEEKIKESILLACNLSY----PNHIKDSDQYFNFGTILKRSLSSE 731
            |                 .|..:|.|:.     |..:    ||...::.|     ..:::.:..:
  Fly   317 T-----------------PCTGQKAKQG-----NAKWRQQQPNPSSNNQQ-----QQMQQQMQQQ 354

  Fly   732 KSIQAFCERCKKFSPTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLST 796
            |       |.:...|...|..:...|   :.|.|               ..|::.|.|:::|.:.
  Fly   355 K-------RGRNKKPGKWSNNIIDNP---NSNHG---------------GSSQQKTCDSSSSSAL 394

  Fly   797 SKPCRYGANCSRSDCHFMHPDRKSP--SHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEVQVQ 859
            |.|.......:.|          ||  |.||.|.|     ||.:|             :.|..::
  Fly   395 SSPTSSATTSATS----------SPTNSPTSYPRA-----NGNRK-------------RIEAALE 431

  Fly   860 TQSDASSGKS------------EQEEETEKPPTKGL-----DNN--RMYALHAVVCQVDDGTQKN 905
            .:.:...|:.            ||.|..:|...:.|     ||:  |:|..     .||....:.
  Fly   432 WRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGF-----PVDSVVHEG 491

  Fly   906 LVSLINVQRPYHTM--KLAESAD-----------DPQSQWYIFNDFSISPVSPQESVWFTLDWKV 957
            .:.:.... |:.:.  .|||:|.           ..:::..:.|.......|||..
  Fly   492 AIEIFKCM-PHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSL--------- 546

  Fly   958 PCILFYRHVEDDSESASTTSSTVTESEETIPSESSSGSPT---------------NLSNP----- 1002
                       ||||....|.:..||..:  |.||:|...               :||.|
  Fly   547 -----------DSESGGEWSGSECESSNS--SSSSAGEAALGLELKYCHFVPVERSLSKPCARCK 598

  Fly  1003 ---FLEEIVSPMLG--------------------------NLSADATLQPLQSDEMPQSGDLVAM 1038
               .::|:....|.                          |...:::......|....||.:|.:
  Fly   599 RHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGV 663

  Fly  1039 DAEFVT-LNPEENEIRPDGKTATIKPCHMS-------VARISCIRGQGPAEGVPFMDDYISTQEK 1095
            :..:.. :..|......|........|.||       |.::|.:    ...|....:.::.....
  Fly   664 NGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTGRGLDVTKVSLV----ALNGQLVYEHFVRPVCD 724

  Fly  1096 VVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQ 1160
            ::||.||:|||...||.:  ..|.|..::   :.|..|:....|.:||||:||.|.:.:.  ...
  Fly   725 IIDYNTQYSGITETDLCS--GAKSLAEVQ---RDLLQLITADTILIGHGLENDLRALRLV--HNT 782

  Fly  1161 IIDT----VHLFHMPHHRMVSLRFLAWHFLGTKIQ----SETHDSIEDARTTLQL 1207
            :|||    .|....|:.|  :||.|....|...||    :..|.|.||:|..::|
  Fly   783 LIDTSISFPHCNGFPYRR--ALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMEL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	64/371 (17%)
		zf-CCCH_2	799..816	CDD:317060	2/16 (13%)
		PAN2_exo	1036..1209	CDD:99846	48/188 (26%)
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	1/35 (3%)
		DnaQ	675..>837	CDD:223916	46/174 (26%)
		REX1_like	686..837	CDD:99848	45/163 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810