DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and ubp13

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_593053.2	Gene:	ubp13 / 2541684	PomBaseID:	SPAC22G7.04	Length:	1088	Species:	Schizosaccharomyces pombe

Alignment Length:	1240	Identity:	372/1240 - (30%)
Similarity:	580/1240 - (46%)	Gaps:	246/1240 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGVLALT 121
            ||.....:||:|||.|.||:|.|::.|.:.|.:..|:..||.|..|... |..:...:.||.:|:
pombe    14 DGVSTCSLSSIAFDPYSELVWTGHKNGQIKSSFGPSLTSYTQFIGHEGP-VHQVLPQERGVFSLS 77

  Fly   122 QTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPH--RLVMAGLQDEL----IDFDLRTLKETRIE 180
            ..|||...|:|..::.::.::..:..:|...|.:  .:|:.|...:|    .:..:...|:..:.
pombe    78 SKSLRLSNRKGTIRWRYQDSDCIDYRAMFYQSRNNPEVVIGGYHQKLTVVNAERGISIHKDKNVS 142

  Fly   181 HVGAGGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGR 245
            .:     .::|:| |.|..|...|.:.|||.||....:.:..||..:||....||||:|||||.|
pombe   143 DI-----FIMRRN-RLLCCGSTNGEIILRDPNSFQPVNKVVAHTGTISDIDTSGNLLLSCGYSLR 201

  Fly   246 QNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRV 310
            .....:|.|:.|:|||.|..:.||.....|.:::..|.|::...|.|..||..:|||....:.::
pombe   202 HGTYMLDPFVKVWDLRNLSSLVPIPFPAGPTIIRMHPKLSTTAVVCSCSGQFHIVDTGNPLDAKL 266

  Fly   311 SMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADV-VP-QLP 373
            ....:.   |.....||:|:..||.|.|...:|::.:.::.|           .|:|: :| |||
pombe   267 MQIPLT---SYLTGMDIASTGDAMVFTDVEDNIHLWSPLENP-----------SFSDLKLPIQLP 317

  Fly   374 MVSITDT-----NFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGY 433
            ..| |:|     |.||:|:.||:..  .:..|.|.:.|: :...:| .:|    ||:.:...|..
pombe   318 NTS-TETVQLENNDPLNSIGLPYYK--DELLSSWSKYLI-FDVGKP-ILD----SNLLIAKQISE 373

  Fly   434 SPNP-----RTARRNQI---PY----VIEQGG-----------VCSPNGNGTAAATKAE-----N 470
            :.:|     ::..||||   |:    :|.:|.           :.|.|....:|:...|     :
pombe   374 NSHPVPQEIKSFHRNQIIEVPWLNRKLISEGATPKFHSERQKDIMSGNDIEGSASYFEEIEDTIS 438

  Fly   471 GVKIIPRRYRKVELKYTKLGTQDFDFDQHNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLE 535
            |...||:.|::..:||:|.|.:||||..:|:|.:||||..:.|||||::||:|.:..:.....:.
pombe   439 GPDSIPKFYQRPVIKYSKFGIEDFDFGFYNKTKYAGLETDITNSYCNSVLQLLSYVPSFSKAAIS 503

  Fly   536 HS---CIKEFCLSCELGFLFNMLDKSTASSPCQASNFLRSFRTVPEASALGLILTDRSSNVNLIS 597
            ||   |....||.|||||||.||.:||..: |||:||||:|.....|.:||::..|.|......|
pombe   504 HSLGPCDLMECLLCELGFLFAMLKESTGRN-CQATNFLRAFSNSSFAQSLGIVFDDYSDGTFPDS 567

  Fly   598 -LIQNWNRFILHQMHYEIFDSSKNASTYSGSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDD 661
             :||.:.:|:|.::                                       ..|:|...|:|.
pombe   568 FVIQKFTKFMLTEI---------------------------------------SRIADYEDKKDG 593

  Fly   662 RERSKINAETDISKIFGTKQICI-----NRCIKC--QEEKIKESILLACNLSYPNHIKDSDQYFN 719
                     |.....|..|..||     .||..|  ..:|||.|:.: .:|.||:  :..:...:
pombe   594 ---------TSFPVSFLLKSFCIPEMQTYRCGICGITSQKIKSSLYI-IDLHYPS--QQLESILS 646

  Fly   720 FGTILKRSLSSEKSI-QAFCERCKKFSPTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCS 783
            |..:.|.||.....: ..:||.|....|                           ||.|...|
pombe   647 FEWLFKMSLDRRVDLPPGWCEYCLAHQP---------------------------FLLRSFIR-- 682

  Fly   784 EKTTVDAAASLSTSKPCRYGANCSRSDCHFMHPDRKSPSHTSQPNAVNNSPNGRQKSWFPLTFTM 848
                                   |..||.|::...|...|...         ..:|:|.|....:
pombe   683 -----------------------SLPDCLFINTQVKHHEHWKL---------WARKNWLPKKLHL 715

  Fly   849 -GINDQGEVQVQTQSDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQV-DDGTQKNLVSLIN 911
             .:||  .:|..:|..::..|.:|             :..:|.|..::.:: .:|.:.:.||.|.
pombe   716 RRVND--TMQCVSQKISNLDKDQQ-------------SLSVYVLRGIIYEIRQNGEEPHFVSTIR 765

  Fly   912 VQRPYHTMKLAESADDP-QSQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYRHVEDDSESAST 975
            |..       ..|:|:| .::|||||||.:..|:.:|::.....||:|.|::|..:
pombe   766 VSD-------NTSSDNPDDNRWYIFNDFLVKEVTEEEALTVHGPWKIPIIVYYEKL--------- 814

  Fly   976 TSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDLVAMDA 1040
                    :..||........|.|..|:......|:       ..:|||.:|||.....||.:|:
pombe   815 --------DTKIPQWDEVSDYTLLYQPYSLNKNPPI-------NKIQPLTTDEMLYPKMLVGIDS 864

  Fly  1041 EFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSG 1105
            |||.|..||.|:|.||..:||||..:|:||:|.:||:||.:|:||:|||::|.:||.||||::||
pombe   865 EFVALQQEETEVRSDGTKSTIKPSKLSLARVSVLRGEGPNKGLPFIDDYVATDDKVTDYLTEYSG 929

  Fly  1106 IKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHM 1170
            |.|||||.:.|...:..||.:|:||:.||:.|.|||||||:.|||:||:.||.||::|||.||.:
pombe   930 IHPGDLDPDRSPYNVVPLKVAYKKLRLLVNAGCIFVGHGLQKDFRIINLLVPPEQVVDTVDLFFL 994

  Fly  1171 -PHHRMVSLRFLAWHFLGTKIQSETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQL 1234
             ...|.:||:||||:.|..:||...|||||||.|.|:||..|.||:.:.|....|.|:||.|::.
pombe   995 SSRQRKLSLKFLAWYLLDEEIQLTEHDSIEDALTALKLYDCYDKLKSQGKLEETLDNIYEVGRRF 1059

  Fly  1235 QWKVP 1239
            :::.|
pombe  1060 KFRPP 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360	65/212 (31%)
		WD40 repeat	148..183	CDD:293791	6/40 (15%)
		WD40 repeat	187..221	CDD:293791	11/33 (33%)
		WD40 repeat	227..273	CDD:293791	21/45 (47%)
		WD40 repeat	278..314	CDD:293791	9/35 (26%)
		UCH_1	505..940	CDD:315986	109/449 (24%)
		zf-CCCH_2	799..816	CDD:317060	4/16 (25%)
		PAN2_exo	1036..1209	CDD:99846	95/173 (55%)
ubp13	NP_593053.2	WD40	18..>220	CDD:295369	63/208 (30%)
		WD40 repeat	141..177	CDD:293791	11/41 (27%)
		WD40 repeat	184..224	CDD:293791	19/39 (49%)
		Peptidase_C19P	458..812	CDD:239137	122/488 (25%)
		UCH_1	473..788	CDD:290159	109/449 (24%)
		DnaQ	744..1040	CDD:223916	134/326 (41%)
		PAN2_exo	860..1034	CDD:99846	95/173 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	202	1.000	Domainoid score	I645
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5918
Inparanoid	1	1.050	459	1.000	Inparanoid score	I287
OMA	1	1.010	-	-		QHG55598
OrthoFinder	1	1.000	-	-		FOG0004707
OrthoInspector	1	1.000	-	-		oto100504
orthoMCL	1	0.900	-	-		OOG6_102772
Panther	1	1.100	-	-	LDO	PTHR15728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R887
SonicParanoid	1	1.000	-	-		X3880
TreeFam	1	0.960	-	-
	14	13.860