Protein Alignment PAN2 and Rexo4

DIOPT Version :10

• Sequence 1: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_997117.2
• Gene: Rexo4 / 227656
• MGIID: 2684957
• Length: 432
• Species: Mus musculus
• Alignment Length: 530
• Identity: 120/530 - (22%)
• Similarity: 181/530 - (34%)
• Gaps: 184/530 - (34%)

  Fly   726 RSLSSEKSIQAFCERCKKFS----PTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKT 786
            |.|:.:|:.:.| .:.|..:    |.:....|...|.....|.. .|.|.:..|.:|.::.:||.
Mouse    39 RKLARKKAKKKF-RKSKALAGSGVPGSHPAAVAGRPPKAPENFS-QNWKALQELLKQKSQAAEKP 101

  Fly   787 TVDAAASLSTSKPCRYGANCSRSDCHFMHP-----DRKSPSHTSQPN------------AVNNSP 834
            .|                  |:.| ..|||     :||..|..|:.:            :|.::|
Mouse   102 LV------------------SQMD-DKMHPQIIQQNRKKASDKSKGDKQRTEKAKSTRGSVTSAP 147

  Fly   835 NGRQKSWFPLTFTMGINDQGEVQVQTQSDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVD 899
            ..| |...|.|.|.|...:...:.:|.||.||     .:...||..|        |..|.|
Mouse   148 TDR-KILVPPTDTSGTEQKKGAKKRTYSDISS-----HQGALKPKWK--------ATEAAV---- 194

  Fly   900 DGTQKNLVSLINVQRPYHTMKLAESADDPQSQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYR 964
                                              |.|    .|...:|.:||
Mouse   195 ----------------------------------ILN----QPTPTEEDIWF------------- 208

  Fly   965 HVEDDSESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEM 1029
               ||.:.        .:.|:.|..|::.             :|...||......:|:..|:
Mouse   209 ---DDVDP--------DDIEDAIGPEAAM-------------LVRKRLGQKKRTISLEKEQA--- 246

  Fly  1030 PQSGDL---VAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYIS 1091
              .|.|   :|:|.|.|.:.|:..|              ...||:|.:...|..    ..|.|:.
Mouse   247 --FGGLTKALALDCEMVGVGPKGEE--------------SIAARVSIVNQYGKC----VYDKYVK 291

  Fly  1092 TQEKVVDYLTQFSGIKPGDL----DANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVI 1152
            ..|.|.||.|..|||:|.:|    :....||.:.      :.||     |.|.|||.|.||.:|:
Mouse   292 PTEPVTDYRTAVSGIRPENLKQGEEFEVVKKEVA------EMLK-----GRILVGHALHNDLKVL 345

  Fly  1153 NIYVPSEQIIDTVHLFHMPHHRMV-----SLRFLAWHFLGTKIQSETHDSIEDARTTLQLYKHYL 1212
            .:..|.::|.||...  .|....|     ||:.|:...||.::|...|.||:||:..::||. .:
Mouse   346 FLDHPKKKIRDTQKF--KPFRSRVKSGRPSLKRLSEKILGIRVQQAEHCSIQDAQAAMRLYV-MV 407

  Fly  1213 KLQEEKKFAN 1222
            |.:.|...||
Mouse   408 KREWESSTAN 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:475233
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:463872	46/234 (20%)
		zf-CCCH_2	799..816	CDD:464217	3/16 (19%)
		PAN2_exo	1036..1209	CDD:99846	53/181 (29%)
Rexo4	NP_997117.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..177		34/156 (22%)
		REX4_like	254..404	CDD:99847	52/180 (29%)