DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAN2 and C05C8.5

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_504838.1	Gene:	C05C8.5 / 179116	WormBaseID:	WBGene00015462	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	79/384 - (20%)
Similarity:	140/384 - (36%)	Gaps:	101/384 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   876 EKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYH-TMKLAESADDPQSQWYIFNDFS 939
            :||....|.::|             ...:|||..:||...:. |..|:..::..:.||...:
Worm    91 QKPRWVSLSHHR-------------NVLQNLVVRVNVDDDFFTTTNLSFLSEFFEKQWIELD--- 139

  Fly   940 ISPVSPQESVW-------FTLDWKV--PCILFYRHVEDDSESAST----TSSTVTESEETIPSES 991
             |.||.:...|       .|:..::  ..::..:..:.|.:...:    |:..:.:.....|.|
Worm   140 -SDVSDRGLFWNSIMQVRLTIQEQIRRKSVIMQKTYDRDGKHDKSHFVLTTEQLAQRRYPFPGE- 202

  Fly   992 SSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDLVAMDAEFVTLNPEENEIRPDG 1056
                         |.:|....|.....|            |..:.::|.|....:....|:
Worm   203 -------------EGVVPTKQGYKKISA------------SSPMFSVDCEMCETDVANREL---- 238

  Fly  1057 KTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRLT 1121
                        .|||.:   ...|.. .:|..:..:.::.||:|::|||.|..::.      :|
Worm   239 ------------TRISIV---DEFENT-ILDTLVKPEGRITDYVTRWSGITPDMMEG------VT 281

  Fly  1122 ALKYSYQK-LKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMV---SLRFLA 1182
            ......|| ::.|:....|.|||.|::|.:.:.:..|.  .:|..|:.:..:....   ||:.|.
Worm   282 TTLGDVQKAIQSLLPPDAILVGHSLEHDLQAMKMTHPF--CLDVGHVLNYTNSNTEFRNSLKNLT 344

  Fly  1183 WHFLGTKIQSE-THDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQLQWKVPE 1240
            ..|||.:|||| .|.|.|||...::|.:  |||::...|.|.         ...||..|
Worm   345 ELFLGAQIQSEFGHCSYEDAWAAMRLAQ--LKLEKGLMFGNV---------SFGWKYSE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:315986	13/64 (20%)
		zf-CCCH_2	799..816	CDD:317060
		PAN2_exo	1036..1209	CDD:99846	44/177 (25%)
C05C8.5	NP_504838.1	REX1_like	222..372	CDD:99848	44/177 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810