Protein Alignment PAN2 and Rexo5

DIOPT Version :10

• Sequence 1: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: XP_315415.5
• Gene: Rexo5 / 1276106
• VectorBaseID: AGAMI1_002655
• Length: 783
• Species: Anopheles gambiae
• Alignment Length: 668
• Identity: 149/668 - (22%)
• Similarity: 248/668 - (37%)
• Gaps: 144/668 - (21%)

  Fly   625 SGS-----VQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAETDISKIFGTKQICI 684
            |||     .|.|..:..||..::.|  |....|:....||..|||.|       .|:.|     :
Mosquito    13 SGSDGVKQAQLSNPSTAAGDGDSLG--DGVGRIALNTKKELRRERKK-------RKLLG-----L 63

  Fly   685 NRCIKCQEEKIKESILLACNLSYPNHIKDSDQYFNFGTILKRSLSSEKSIQAFCERCKKFSPTNQ 749
            :..:...|:....|...:...:.||...|.|...:.|.  ...|:||.:....           |
Mosquito    64 SALLMLNEQDDIGSSRNSSRTTQPNVAGDVDDDDDVGN--SDQLTSESNNNKL-----------Q 115

  Fly   750 SVKVTSLPQILSIN-----CGLNNEKDITFLKRQLNRCSEKTTV---DAAASLSTSKPCRYGANC 806
            :.....|.|||:.|     .|...|......||:...||.....   |.||:....|....||:
Mosquito   116 NGADDRLKQILANNHTAYAIGDEEEAPTVSAKRRREECSSNGAAAENDNAATAVKCKTLASGAD- 179

  Fly   807 SRSDCHFMHPDRKSPSHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEV----QVQTQSDASSG 867
                        |:.:..:.|  :||....|....:       :|.:..:    :|..:....:.
Mosquito   180 ------------KAAAAATGP--LNNDTEYRALKAY-------VNQKKSMRYVPRVLLKPIGQNA 223

  Fly   868 KSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSL-INVQRPYHTMKLAE--SADD-- 927
            ..::.|:.|......||:.:...:|.:: :.|.......||: .|.:..:.|:.:.|  |.:|
Mosquito   224 LLDRNEKKEDRIPLLLDDIQALLMHTLL-RTDSPLAPRWVSIDKNTKLTHTTVLIVEGFSCEDYV 287

  Fly   928 ------PQSQWYIFN-DFSISPVSPQESVWFTLDWKVPCILFYRHVED--DSESASTTSSTVTES 983
                  |.....||. ..::..|.|...:   |: :|.|:......:|  .:|..|..::.....
Mosquito   288 TYREHMPNCADTIFGPQLTLQVVFPSTKI---LE-EVACVPLSDTHKDVLVAEYGSLEAAMRMCK 348

  Fly   984 EETIPSES---SSGSP-----TNLSNPFLEEIVSPMLGNLSADATLQPLQ----SDEMPQSGDLV 1036
            ::.:..:|   :.|||     :::..|..::....:|       .|.|:|    ...||.:|.|.
Mosquito   349 DQMLVRKSVFRNIGSPRKSPCSDVDLPESDKFPRTLL-------LLSPIQMINEGYPMPLAGTLE 406

  Fly  1037 AMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDD--------YISTQ 1093
            .....:||.:.....:.|......| .|.|..|    |.|:.....|..:|:        .:..:
Mosquito   407 NKYKHYVTTSDSYKPVNPRSPMFGI-DCEMCGA----IGGKSVLTRVSIVDEQQKVIYNKLVKPR 466

  Fly  1094 EKVVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPS 1158
            ||::||.|:||||     .|:..:...|.|....:||:.|:....|.|||.|.:|...:.:..|
Mosquito   467 EKIIDYRTKFSGI-----TASMLRDVRTTLADVQRKLRELLPPDAILVGHSLNSDLLAMELLHP- 525

  Fly  1159 EQIIDTVHLFHM---PHHRMVSLRFLAWHFLGTKIQSET--HDSIEDARTTLQLYKHYLKLQEEK 1218
             .:|||..::::   |.|:. .|:.|...||..:||..|  ||||||...:|:|.:  |||....
Mosquito   526 -YVIDTSIIYNVTGNPMHKQ-KLKILTKKFLDQEIQCSTGGHDSIEDCAASLKLVQ--LKLANSI 586

  Fly  1219 KFANALKNLYERGKQLQW 1236
            .|.:            ||
Mosquito   587 YFGD------------QW 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:475233
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:463872	69/343 (20%)
		zf-CCCH_2	799..816	CDD:464217	2/16 (13%)
		PAN2_exo	1036..1209	CDD:99846	53/185 (29%)
Rexo5	XP_315415.5	None