DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PAN2 and Pan2

DIOPT Version :9

Sequence 1:	NP_610427.2	Gene:	PAN2 / 35893	FlyBaseID:	FBgn0033352	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	XP_006513048.1	Gene:	Pan2 / 103135	MGIID:	1918984	Length:	1205	Species:	Mus musculus

Alignment Length:	1301	Identity:	526/1301 - (40%)
Similarity:	721/1301 - (55%)	Gaps:	202/1301 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSAPGNGHFSPSFNGF---------------NIGTTDPE-------------------YVELVPV 54
            |..||...|||:.:..               |: ..|||                   |.||..|
Mouse     5 GLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNV-ELDPEGVALEALPVQESVHIMEGVYSELHSV 68

  Fly    55 LADGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGVLA 119
            :|:.|....||.  ||.:||:||:|:.|||.||::..::::|:||||:..|.:|.|.:|::|:|.
Mouse    69 VAEVGVPVSVSH--FDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGGDDIRQIQSLENGILF 131

  Fly   120 LTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGLQDELIDFDLRTLKETRIEHVGA 184
            ||:.:|::..|.||..|.:..:..::|.|:|......|::.|||:.:::.||.|::||:...|..
Mouse   132 LTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTDNSTLLVGGLQNHVLEIDLNTVQETQKYAVET 196

  Fly   185 GGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGRQNNL 249
            .|.|::|:.:|:.|.|...|.|:||||.|..|:|.....:..||||.|.||||.:||:|.|...|
Mouse   197 PGVTIMRQTNRFFFCGHTSGKVSLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGL 261

  Fly   250 AIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSMYQ 314
            |.||||.||||||:|.|.|:||.:||..|:|:|:.||:||::|..||.|..:...|:.| ..::.
Mouse   262 ACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANP-ADIFH 325

  Fly   315 INTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFA--DVVPQLPMVSI 377
            :|..|...::||:|:|.||:||||..|.:::  ...:|:|.||.|||.||||  .:|..||.:..
Mouse   326 VNPVGPLLMTFDVSASKQALAFGDSEGCVHL--WTDSPEPSFNPYSRETEFALPCLVDSLPPLDW 388

  Fly   378 TDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGYSPNPRTARR 442
            :....|||.:.:| |||.. ..||||.........|...:|.|:|..||..|.|||:|||||..|
Mouse   389 SQDLLPLSLIPVP-LTTDA-LLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLR 451

  Fly   443 NQIPYVIEQGG---------VCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDFDQ 498
            |||||.:::..         ..||.|       :.|..:..:.::||||.:||:|||.:||||..
Mouse   452 NQIPYRLKESDHEFDNFSQVTESPTG-------REEEPLHTVSKKYRKVTIKYSKLGLEDFDFKH 509

  Fly   499 HNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTASSP 563
            :|:|.|||||..:||:|||.|:|:|||.:.:|..:..|.|.|||||:|||||||:|||.| ...|
Mouse   510 YNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLS-RGDP 573

  Fly   564 CQASNFLRSFRTVPEASALGLILTD---RSSNVNLISLIQNWNRFILHQMHYEIFDSSKNASTYS 625
            ||.|||||:|||:||||||||||.|   .|...:|..|||.||||||.|:|.:: ...:....|.
Mouse   574 CQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDM-QELEVPQAYR 637

  Fly   626 GSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAETDISKIFGTKQICINRCIKC 690
            |          ||.|....|.   |||                    |.::|..:....:.| :|
Mouse   638 G----------AGGSSFCSSG---DSI--------------------IGQLFSCEMENCSLC-RC 668

  Fly   691 QEEKIKESILLACNLSYP-NHIKD-SDQYFNFGTILKRSLSSEKSIQAFCERCKKFSPTNQSVKV 753
            ..|.::.|..|...|||| ..|.| :.:.::|..:||||:..|::.||:|:.|:|:.||.|:..:
Mouse   669 GSETVRASSTLLFTLSYPEGSICDKTGKNYDFAQVLKRSICLEQNTQAWCDNCEKYQPTIQTRNI 733

  Fly   754 TSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLSTSKPCRYGANCSRSDCHFMHPDR 818
            ..||.||.|||.:|:.|:..|.:.|         .:.|..::..|   ||......:  |...||
Mouse   734 RHLPDILVINCEVNSSKEADFWRLQ---------AEVAFKIAVKK---YGGEMKSKE--FALADR 784

  Fly   819 KSPSHTSQPNAVNNSPNG--------RQKSWFPLTFTMGINDQGEVQVQTQSD----------AS 865
            |.          ..||.|        .:..|.|.:..|.:.....:.|...:|          :.
Mouse   785 KE----------LRSPEGFLCSSIEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGAPSQ 839

  Fly   866 SGKSEQEEETEKPPTKGLDNNRMYALHAVVCQV-DDGTQKNLVSLINVQRPYHTMKLAESADDPQ 929
            .|.:..|||.      |:   .:|.|.|.|..: |..|..:||:.|.|...||..|...:    .
Mouse   840 WGPARAEEEL------GV---YVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVT----H 891

  Fly   930 SQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTSSTVTESEETIPSESSSG 994
            .|||:||||.|.|:...|:|.|.::||||.||:|                       :....:|.
Mouse   892 QQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYY-----------------------VKRNLNSR 933

  Fly   995 SPTNLSNPFLEEIVSPMLGNLSADATLQ-----------PLQSDEMPQSGDLVAMDAEFVTLNPE 1048
            ...|:.||....:       |.|:|:|.           ||..:||||.||||.:||||||||.|
Mouse   934 YNLNIKNPIEASV-------LLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTLNEE 991

  Fly  1049 ENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDA 1113
            |.|:|.||..:||||..||||||:|:|||||.||:||:||||||||:|||||||:||||||||||
Mouse   992 EAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDA 1056

  Fly  1114 NFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMVSL 1178
            ..|.|.||.||.:|.||::|:|:||.||||||:.||||||:.||.:|::|||:|||||..||:||
Mouse  1057 KISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISL 1121

  Fly  1179 RFLAWHFLGTKIQSETHDSIEDARTTLQLYKHYLKLQ----EEKKFANALKNLYERGKQLQWKVP 1239
            |||||:||..|||.|||||||||||.||||:.||:|.    |.:.|...||.|||:|:::.||||
Mouse  1122 RFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVP 1186

  Fly  1240 E 1240
            |
Mouse  1187 E 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAN2	NP_610427.2	WD40	63..>270	CDD:330360	88/206 (43%)
		WD40 repeat	148..183	CDD:293791	11/34 (32%)
		WD40 repeat	187..221	CDD:293791	14/33 (42%)
		WD40 repeat	227..273	CDD:293791	30/45 (67%)
		WD40 repeat	278..314	CDD:293791	13/35 (37%)
		UCH_1	505..940	CDD:315986	156/458 (34%)
		zf-CCCH_2	799..816	CDD:317060	3/16 (19%)
		PAN2_exo	1036..1209	CDD:99846	124/172 (72%)
Pan2	XP_006513048.1	WD40	75..357	CDD:421866	118/286 (41%)
		UCH_1	516..902	CDD:404327	156/458 (34%)
		PAN2_exo	979..1152	CDD:99846	124/172 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843047
Domainoid	1	1.000	342	1.000	Domainoid score	I1068
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5918
Inparanoid	1	1.050	865	1.000	Inparanoid score	I419
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55598
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004707
OrthoInspector	1	1.000	-	-		oto92067
orthoMCL	1	0.900	-	-		OOG6_102772
Panther	1	1.100	-	-	LDO	PTHR15728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R887
SonicParanoid	1	1.000	-	-		X3880
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790