DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8237 and FAM8A1

DIOPT Version :9

Sequence 1:	NP_610425.1	Gene:	CG8237 / 35891	FlyBaseID:	FBgn0033350	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_057339.1	Gene:	FAM8A1 / 51439	HGNCID:	16372	Length:	413	Species:	Homo sapiens

Alignment Length:	363	Identity:	98/363 - (26%)
Similarity:	153/363 - (42%)	Gaps:	80/363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GEQGEETGQKLTERSTKEA-----------------YFESLAEWAKQATLA----QNAMLMFPYY 45
            ||....:|.:|.|::..||                 |...:.||..|:...    .:.:..||.|
Human    77 GEAASGSGAELQEQAGCEAPEAAAPRERPARLSAREYSRQVHEWLWQSYCGYLTWHSGLAAFPAY 141

  Fly    46 LMAN-YPTMFPGLPSSAALQAAAMGQPQA--------LVQGSAAAPGEPAAEPRLPAPNFSGLRI 101
            .... .|..||. ..:|..||||...||.        |..|:|......||....||| .:||..
Human   142 CSPQPSPQSFPS-GGAAVPQAAAPPPPQLGYYNPFYFLSPGAAGPDPRTAAGISTPAP-VAGLGP 204

  Fly   102 LGEAAQLDI----IQRLG---------------GYEYVLSPFWKRAVAETIDMFILFIVKIIITF 147
            .....|..:    :.|:|               |.|||:.....|.:||.:|.||||.:|..|..
Human   205 RAPHVQASVRATPVTRVGSAAPSRSPSETGRQAGREYVIPSLAHRFMAEMVDFFILFFIKATIVL 269

  Fly   148 GVVNLFNI----EFDEDVIRRTLDQEDLFSNFFDTSLDFISMSTDLLLIEMLTKFIVCCYEALWT 208
            .:::|..|    :|....|...:|:        |||::.:.   .::::.::.:.:||.||.:..
Human   270 SIMHLSGIKDISKFAMHYIIEEIDE--------DTSMEDLQ---KMMVVALIYRLLVCFYEIICI 323

  Fly   209 YLYQGATPGKSLMKIRIYYVEAVMPLQGPPLPQFVLQPQREPMRALLYPPQTPSLMRSFARALIK 273
            :...||||||.|:.:|:...:..:.:              .|.|.|:.|....|:..|..|||||
Human   324 WGAGGATPGKFLLGLRVVTCDTSVLI--------------APSRVLVIPSSNVSITTSTIRALIK 374

  Fly   274 NLGMTLLFPICVLMVFFKNNRTAYDVLTKTIVVESNSI 311
            |..:...||..:.::||::||||||::..||||:.|.:
Human   375 NFSIASFFPAFITLLFFQHNRTAYDIVAGTIVVKRNGV 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8237	NP_610425.1	RDD	123..302	CDD:294483	52/182 (29%)
FAM8A1	NP_057339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		7/27 (26%)
		Atrophin-1	<5..233	CDD:331285	37/157 (24%)
		Necessary and sufficient to interact with SYVN1. /evidence=ECO:0000269\|PubMed:28827405	107..139		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..236		2/18 (11%)
		RDD	244..403	CDD:310697	52/183 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147026
Domainoid	1	1.000	49	1.000	Domainoid score	I11895
eggNOG	1	0.900	-	-		E1_KOG4647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4983
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1123503at2759
OrthoFinder	1	1.000	-	-		FOG0005417
OrthoInspector	1	1.000	-	-		oto91784
orthoMCL	1	0.900	-	-		OOG6_107529
Panther	1	1.100	-	-	LDO	PTHR13659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3819
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790