DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and GIT2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_476510.1	Gene:	GIT2 / 9815	HGNCID:	4273	Length:	759	Species:	Homo sapiens

Alignment Length:	189	Identity:	56/189 - (29%)
Similarity:	85/189 - (44%)	Gaps:	33/189 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWTPEQVIS 85
            :::.||  .::.|.||....|.|||.|.|.|||..|..:||:||.|||:|:.:....|.|..:..
Human     1 MSKRLR--SSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQM 63

  Fly    86 LQQMGNSRARAVYEAQLPD------GFRR--PQTDTALEN---FIRAKYEHKKYLAREWVPPSPP 139
            ::.:.|:.|.:::|..|.|      |.|:  || |....|   ||||||:...::.|  :|....
Human    64 VETLYNNGANSIWEHSLLDPASIMSGRRKANPQ-DKVHPNKAEFIRAKYQMLAFVHR--LPCRDD 125

  Fly   140 KVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALK----NTPL 194
            ....||::.::|....|..........|.|             |:.|:...    ||||
Human   126 DSVTAKDLSKQLHSSVRTGNLETCLRLLSL-------------GAQANFFHPEKGNTPL 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	42/121 (35%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	56/189 (30%)
GIT2	NP_476510.1	ArfGap	2..124	CDD:214518	44/126 (35%)
		ANK	109..220	CDD:238125	17/78 (22%)
		ANK 1	132..161		6/41 (15%)
		Ank_2	137..229	CDD:289560	10/48 (21%)
		ANK repeat	137..165	CDD:293786	6/40 (15%)
		ANK 2	166..195		4/6 (67%)
		ANK repeat	167..197	CDD:293786	4/5 (80%)
		ANK 3	199..228
		GIT_SHD	266..294	CDD:285690
		GIT_SHD	330..358	CDD:285690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..422
		GIT_CC	414..478	CDD:293167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..643
		GIT1_C	638..752	CDD:289013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900