Protein Alignment CG8243 and ARFGAP2

DIOPT Version :9

• Sequence 1: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_005253223.1
• Gene: ARFGAP2 / 84364
• HGNCID: 13504
• Length: 560
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 137/586 - (23%)
• Similarity: 213/586 - (36%)
• Gaps: 131/586 - (22%)

  Fly    18 QTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDT-WTPE 81
            |||..::.....||.|.||.||.|.|||...|:||||.|:|:||:||||:|.::|..||: |...
Human    11 QTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWF 75

  Fly    82 QVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALENFIRAKYEHK------KYLAREWVPPSPPK 140
            |:..:|..||:.|.|.:...   |......:|...:.....|..|      ..|||.....
Human    76 QLRCMQVGGNANATAFFRQH---GCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDL---- 133

  Fly   141 VDWAKEIDEELERQKRKKKSTQ--AQATLGLAGVAGGSGDKRLSGSS--------------ASAL 189
              |...:...:.....:||.:.  .:.|..|.|:......:.|:.:|              |:..
Human   134 --WIDNMSSAVPNHSPEKKDSDFFTEHTQVLVGLGASCQQEWLTEASVIWPPFQPPAWDAPATEP 196

  Fly   190 KNTPLPAP------LPKPK--PN-QVGGCSPKTT-QRVQLNSSGVSSAGE--SDLLGLSSPTKPI 242
            ..|..|||      |.:|:  || .:.|.|||.: :.|.|::.|...|.|  |.::|...|....
Human   197 SGTQQPAPSTESSGLAQPEHGPNTDLLGTSPKASLESVYLSAKGALPARELKSSIIGKKKPAAAK 261

  Fly   243 VATNASQDL--QNESFTSFLSAESIAGQPDKPIGSNGDAANLMGSKPNSLA-------------- 291
            ....|.:.|  |..|..||...|..|...:|.  ....||:.......|:.
Human   262 KGLGAKKGLGAQKVSSQSFSEIERQAQVAEKL--REQQAADAKKQAEESMVASMRLAYQELQIDR 324

  Fly   292 -QEEQDFFN-QGS-------LGAG------------------GNEKDQSGKMSKDSI-----LAL 324
             :||:...| :|.       ||.|                  ..|...|.|.|:..:     :..
Human   325 KKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGT 389

  Fly   325 YGSAPATH--NP---QMNFGG--FTGMAPGGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNA 382
            :.|.|..:  ||   ..:||.  .|..|.|....::::.::....:.|.:..:.....|    .:
Human   390 FASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREV----ES 450

  Fly   383 FSNAAISSATAMSMGGSHGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPLFGAVPQQQ 447
            .|:...||.......|:...:...|   .|....|..:|.:.....:..|.:|...|||
Human   451 RSSGLESSEARQKFAGAKAISSDMF---FGREVDAEYEARSRLQQLSGSSAISSSDLFG------ 506

  Fly   448 QQHQQQLQQQHHPQLGGLSMNLMQPLPSGLNIGQPPQG----AGGFAATGPTTSSVPSNLNQQFG 508
                 .:...|    |..|::|...||:. :|.|..||    ||..|.   ..:.|.::|..::|
Human   507 -----DMDGAH----GAGSVSLGNVLPTA-DIAQFKQGVKSVAGKMAV---LANGVMNSLQDRYG 558

  Fly   509 N 509
            :
Human   559 S 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	44/120 (37%)
		COG5347	20..300	CDD:227651	87/332 (26%)
ARFGAP2	XP_005253223.1	PLN03114	1..510	CDD:178661	121/527 (23%)
		ArfGap	11..117	CDD:279720	41/108 (38%)
		RILP-like	266..>338	CDD:304877	16/73 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810