DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and smap1

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021336343.1	Gene:	smap1 / 777731	ZFINID:	ZDB-GENE-060920-2	Length:	483	Species:	Danio rerio

Alignment Length:	559	Identity:	194/559 - (34%)
Similarity:	268/559 - (47%)	Gaps:	141/559 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGV 65
            |::.:..::.:.:.|:.|.:|::|||::|||||.||:||||||||||||:|:|||||||||||||
Zfish     1 MTTRSEREKAQKLNEQHQAILSKMLREDDNKYCADCEAKGPRWASWNLGVFICIRCAGIHRNLGV 65

  Fly    66 HISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALENFIRAKYEHKKYLA 130
            |||||||||||.|||||:.|:|.|||::||.:|||.||:.|||||||.|:|.|||.|||.|||..
Zfish    66 HISRVKSVNLDQWTPEQIQSVQSMGNTKARQLYEAHLPENFRRPQTDQAVEFFIRDKYERKKYYD 130

  Fly   131 REWV------------PPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSG 183
            :..|            ..|.|....|::...|.||:|:|::..:.:.|           ||...
Zfish   131 KNSVNGAIKSSDAALPSVSSPSSQAAEKSKLEKEREKKKEEKKREKDT-----------DKENK- 183

  Fly   184 SSASALKNTPLPAPLPKPK-PNQVGG-CSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATN 246
                       ||.|.|.: .||:.. .|||.           |:....|||||.:||....::.
Zfish   184 -----------PAVLEKKREDNQIDSRISPKK-----------SAEPAIDLLGLDAPTVGSASSG 226

  Fly   247 A-------------------SQDLQNESFTSFLSAESIAGQPDKPIGSNGDAANLMGSKPNSLAQ 292
            |                   |..|.:.|.:|.:|:...||.. :...:.|..|...|:...:.||
Zfish   227 AGTSSAAPISDDLDIFGPMVSNPLPSNSNSSQVSSSKAAGSA-QASSAGGAVAGATGTGSAAPAQ 290

  Fly   293 EEQDFFNQGSLGAGGNEKDQSGK--MSKDSILALYGS-------APAT------------HNPQM 336
            .:.|.|::.|   |.::.:.|.|  :||||||:||||       |.||            ..||.
Zfish   291 GDLDLFSETS---GNSKAEDSAKKPLSKDSILSLYGSSTVPQQPAQATAMFMGPSQMQFPAQPQG 352

  Fly   337 NFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGS-- 399
            ||..|.||  ||.|              ||.:       :|.|......|.:...|.|.:|.:
Zfish   353 NFQAFPGM--GGAM--------------PPTT-------MMGAVMGQGGAMMGQNTGMMVGMTMP 394

  Fly   400 HGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPLFGAVP-QQQQQHQQQLQQQHHPQLG 463
            :||.|...|...|   .|.|       |...|.::....::...| ||.|.:..|:.|    |:.
Zfish   395 NGFMGNAQPGVMG---LAPG-------MMGPQGMVPPQNMYAMQPGQQGQWNMAQINQ----QMS 445

  Fly   464 GLSMNLMQPLPSG--LNIGQPPQGAGGFAA--TGPTTSS 498
            |:::|     .||  :..|||....||:.|  :|.|.|:
Zfish   446 GMNLN-----GSGAPMAFGQPGAPMGGWVAPPSGQTLST 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	84/113 (74%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	127/312 (41%)
smap1	XP_021336343.1	ArfGap	18..132	CDD:307528	84/113 (74%)
smap1	XP_021336343.1	Med15	<329..>466	CDD:312941	44/178 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3227
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3372
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097163at2759
OrthoFinder	1	1.000	-	-		FOG0001773
OrthoInspector	1	1.000	-	-		otm24882
orthoMCL	1	0.900	-	-		OOG6_100831
Panther	1	1.100	-	-	O	PTHR45705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1895
SonicParanoid	1	1.000	-	-		X1301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860