DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8243 and Appl1

DIOPT Version :9

Sequence 1:NP_610424.1 Gene:CG8243 / 35890 FlyBaseID:FBgn0033349 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_660256.1 Gene:Appl1 / 72993 MGIID:1920243 Length:707 Species:Mus musculus


Alignment Length:430 Identity:81/430 - (18%)
Similarity:122/430 - (28%) Gaps:158/430 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 EQVIS--LQQMGN-----SRARAVYEAQLPDGFRRPQTD----------TALENFIRAKYEHKKY 128
            ::|:|  |||...     |...||...||.|....|.:.          |..|.|..|..:|...
Mouse    79 DEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAA 143

  Fly   129 LAREWVPPSPPKVDWAK-EIDEELERQKRKKKST---------------------------QAQA 165
            :.|........:.|..| |:.|::...::|:..|                           |||.
Mouse   144 INRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQI 208

  Fly   166 T---LGLAGVAGG-------------------SGDKRLSGSSASALKNTPLPAPLPKPKPNQVGG 208
            :   :|...:.|.                   .||......:...|:....|..||.|.|.:...
Mouse   209 SFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPI 273

  Fly   209 CSPKTTQRVQLNSSG----VSSAGESDLL-----GLSSPTKPIVATNASQDLQNES--------- 255
            ....|.:...||:..    |||..:....     .|.|..:..||...:.|:.|.|         
Mouse   274 NRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDR 338

  Fly   256 -----FTSF-------LSAES-------------------IAGQPDKPIGSNGDAANLMGSKPNS 289
                 .|||       |.|||                   ::..|::.......:| |....|:.
Mouse   339 RYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSA-LEAVTPSP 402

  Fly   290 LAQEEQDFFNQG-----------SLGAGGNEKDQSGKMSKDSILA-------------------- 323
            ..|:..:....|           |.|:.|:|......:|.||::|                    
Mouse   403 SFQQRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQ 467

  Fly   324 --LYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQ 361
              .:|......||   ||     ..||....:.:..|.||
Mouse   468 AKAFGQGGRRTNP---FG-----ESGGSTKSETEDSILHQ 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8243NP_610424.1 ArfGap 18..132 CDD:279720 17/67 (25%)
COG5347 20..300 CDD:227651 62/334 (19%)
Appl1NP_660256.1 Required for RAB5A binding. /evidence=ECO:0000250 1..428 64/349 (18%)
BAR_APPL1 20..234 CDD:153315 29/154 (19%)
BAR-PH_APPL 252..376 CDD:270067 26/123 (21%)
PH 280..375 CDD:278594 19/94 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 6/35 (17%)
F&H. /evidence=ECO:0000250 403..414 1/10 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..490 7/31 (23%)
PTB_APPL 489..624 CDD:269980 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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