DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Arap1

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006508249.1	Gene:	Arap1 / 69710	MGIID:	1916960	Length:	1452	Species:	Mus musculus

Alignment Length:	454	Identity:	107/454 - (23%)
Similarity:	162/454 - (35%)	Gaps:	95/454 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLD--TWTPEQVISLQQMGNS 92
            |::|.||.|..|.|||.||.:.:|.||||.||.||..:|:|:|:.:|  .||...:.....:||.
Mouse   549 NRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEALIQLFLHLGNG 613

  Fly    93 RARAVYEAQLP--DGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPKVDWAKEIDEELERQK 155
            .....:.|.:|  :......:..|....:.|||...||  |.:    .|.....:|:|:.|....
Mouse   614 PGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKY--RRY----HPLFGNQEELDKALCAAV 672

  Fly   156 RKKKSTQAQATLGL-AGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQVGGCSPKTTQRVQL 219
            ......:.||.||. |||:..|||.               .||.|.....|.|    :|.|...|
Mouse   673 TTTDLAETQALLGCGAGVSCFSGDP---------------AAPTPLALAEQAG----QTLQMEFL 718

  Fly   220 NSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGDAANLMG 284
            .::..:.....|      ..||: ..:.|..|...|.:.||...:.||:|
Mouse   719 RNNQSTEVPRLD------SVKPL-EKHYSVTLPTVSHSGFLYKTASAGKP--------------- 761

  Fly   285 SKPNSLAQEEQD----FFNQGSLGAGGNEK--DQSGKMSKDSILALYGSAPATHNPQMNFGGFTG 343
             ..:..|:||..    ..:.|.|....||:  ..:|::....|:.|..|...||..:..|..:|
Mouse   762 -LQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYT- 824

  Fly   344 MAPGG--YMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGSHGFTGAQ 406
              .|.  |:...:..::.|::             |.....||.........|           ..
Mouse   825 --EGERLYLFGLENAELAHEW-------------VKCIAKAFVPPLAEDLLA-----------RD 863

  Fly   407 FPSTGGSPYAAAGQAAATNLMQTNQS--ILSGMPLFGAVPQQQQQHQQQLQQQHHPQLGGLSMN 468
            |...|..|.     .|..:|.|..:.  .|:|..|....|:...:...||::.....:.|.|.|
Mouse   864 FERLGRLPC-----KAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRKLQELSIQGDSEN 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	36/105 (34%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	73/278 (26%)
Arap1	XP_006508249.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	331..422	CDD:270073
		PH2_ARAP	438..527	CDD:270074
		ArfGap_ARAP	537..652	CDD:350066	36/104 (35%)
		PH3_ARAP	745..851	CDD:270076	25/137 (18%)
		PH-like	864..954	CDD:388408	15/64 (23%)
		RhoGAP_ARAP	959..1137	CDD:239850
		RA_ARAP1	1173..1265	CDD:340746
		PH5_ARAP	1265..1404	CDD:270079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900