DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Asap3

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_038967221.1	Gene:	Asap3 / 684122	RGDID:	1593929	Length:	903	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	120/520 - (23%)
Similarity:	188/520 - (36%)	Gaps:	141/520 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LTQMLRDE-----DNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWTP 80
            ||.||..|     .|.:|.||.|..|.|.|.|||:..||:|:|:||.|||..||::|:.||...|
  Rat   423 LTNMLVAEVKSRPGNDHCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRYSRIQSLTLDLLGP 487

  Fly    81 EQVISLQQMGNSRARAVYEAQLPD-GFRRPQTDTAL---ENFIRAKY-EHKKYLAREWVPPSPPK 140
            .:::....:|||....|.||.||. |..:|..::.:   .|:|.||| |||  .||...|
  Rat   488 SELLLALNIGNSHFNEVMEAHLPSHGSPKPSAESDMSSRRNYIVAKYVEHK--FARRSTP----- 545

  Fly   141 VDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQ 205
                       |.||.:...........|...|.|....:|                ||.|....
  Rat   546 -----------EPQKLRTAICSRDLLSVLEAFANGQDFGQL----------------LPGPDGQA 583

  Fly   206 VGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIV----ATNASQDLQNESFTSFLSAESIA 266
            .|..:.....||         |.::.|        |||    ......|.:.....:.|...::.
  Rat   584 PGELALHLAIRV---------ASQASL--------PIVDFLIQNGGHLDAKAADGNTALHCAALH 631

  Fly   267 GQPD---------KPIGSNGDAANLMGSKPNSLAQEEQDFFNQGSLGAGGNEKDQSGKMSKDSIL 322
            ||.|         .|:|    |.|..|.....:|:.:|....:..|     |:.|:|.::....:
  Rat   632 GQLDCLKLLLKGRAPMG----AVNNAGETALDVARNKQHKDCEELL-----EQAQAGTLAFPLPM 687

  Fly   323 ALYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAA 387
            ..:......|       ||         ..:::::..|..:.||            |...:|:..
  Rat   688 DYHWGHSMDH-------GF---------DSEEEEEEKHCPVKPP------------AQACWSSGR 724

  Fly   388 --ISSATAMSMGGSHGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPLFGA-----VPQ 445
              ||:.|..:: .:.|.|.:|..|....|        ...:..::::||.|.....:     :|.
  Rat   725 LDISNRTYETV-ANPGPTSSQSQSEDSPP--------PLPIKNSSRTILLGRAGDSSRDRSDIPS 780

  Fly   446 QQQQHQQQLQQQHHP-----------QLGGLSMNLMQPLPSGLNIGQPPQGAGGFAATGPTTSSV 499
            .:.:..:..:.:..|           :.||||..|..|..|   :.:||..:....|:|.|.:.|
  Rat   781 LRSESPEASENRSSPASSSSSFTSSVEPGGLSQALPSPEES---LQEPPGTSRPGLASGTTPAEV 842

Fly 500 499
Rat 843 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	50/120 (42%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	82/301 (27%)
Asap3	XP_038967221.1	BAR_ASAP3	35..243	CDD:153324
		PH_ASAP	294..400	CDD:270071
		ArfGap_ASAP3	423..543	CDD:350087	51/121 (42%)
		ANK repeat	550..583	CDD:293786	7/48 (15%)
		ANK repeat	585..618	CDD:293786	9/49 (18%)
		Ank_2	589..674	CDD:403870	20/110 (18%)
		ANK repeat	620..651	CDD:293786	7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000