DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8243 and ARAP3

DIOPT Version :9

Sequence 1:NP_610424.1 Gene:CG8243 / 35890 FlyBaseID:FBgn0033349 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_071926.4 Gene:ARAP3 / 64411 HGNCID:24097 Length:1544 Species:Homo sapiens


Alignment Length:462 Identity:104/462 - (22%)
Similarity:149/462 - (32%) Gaps:179/462 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 QTLLTQMLRDED----------NKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKS 72
            |..:|:.|.|.:          |:.|.||.:..|.||:.|||:.:|.:|||.||.||..||:|:|
Human   479 QEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQS 543

  Fly    73 VNLDT--WTPEQVISLQQMGNSRARAVYEAQLP--DGFRRPQTDTALENFIRAKYE-------HK 126
            :.|||  |:.|.|.....:||.||...:...||  :|.....|......||..||.       |.
Human   544 LKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHP 608

  Fly   127 KY-------------LAR--------------------EWVPPSP-----------PKVDWAKEI 147
            :|             :||                    .|.||:|           |......|:
Human   609 QYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEV 673

  Fly   148 DEELERQKRKKKSTQAQATLG-------LAGVAGGSGDKR----------LSGSSAS--ALKNTP 193
                          ..:||..       ::..||.|..:|          :.|::..  |.:|:|
Human   674 --------------VVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSP 724

  Fly   194 LPAPLPKPKPNQVGGCSPKTTQ----------------RVQ-LNSSG-------VSSAGE----- 229
            .|..|.:|:.....|.||..|.                |:| ..:.|       .|:.|:     
Human   725 EPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPL 789

  Fly   230 --SDLLG----------LSSPTKPIVATN-------------------------ASQDLQNESFT 257
              ..|||          |.||:....|..                         |.:|:.:....
Human   790 SCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRL 854

  Fly   258 SFLSAESIAGQPDKP----IGSNGDAANLMGSKPNSLAQEEQDF--FNQ--GSLGAGGNEKDQSG 314
            ..:|..|.|..|||.    :...|....|.|       :...||  :|.  |....||....|..
Human   855 QEISVVSAADTPDKKEHLVLVETGRTLYLQG-------EGRLDFTAWNAAIGGAAGGGGTGLQEQ 912

  Fly   315 KMSKDSI 321
            :||:..|
Human   913 QMSRGDI 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8243NP_610424.1 ArfGap 18..132 CDD:279720 48/167 (29%)
COG5347 20..300 CDD:227651 95/435 (22%)
ARAP3NP_071926.4 SAM_Arap1,2,3 4..66 CDD:188889
SAM 12..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..194
PH 288..379 CDD:278594
PH1_ARAP 289..381 CDD:270073
PH2_ARAP 398..479 CDD:270074 104/462 (23%)
PH 399..482 CDD:278594 1/2 (50%)
ArfGap 490..606 CDD:279720 40/115 (35%)
PH3_ARAP 676..786 CDD:270076 22/109 (20%)
PH-like <846..894 CDD:302622 12/54 (22%)
RhoGAP_ARAP 909..1084 CDD:239850 4/11 (36%)
RA 1117..1209 CDD:279168
PH5_ARAP 1212..1331 CDD:270079
PH 1241..1325 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1422..1544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.