DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Acap2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_017453554.1	Gene:	Acap2 / 619382	RGDID:	1562939	Length:	816	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	123/513 - (23%)
Similarity:	187/513 - (36%)	Gaps:	151/513 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHI 67
            |.::|..:|....|.::.|.::.....|..|.||....|||||.|||:.|||.|:||||:||||.
  Rat   395 SLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 459

  Fly    68 SRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPD-GFRRPQTDTALEN--FIRAKYEHKKYL 129
            |:|:|:.||||.||.:..:.::||.....||||:|.. |.::||.....|.  :|||||..:|::
  Rat   460 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIRAKYVERKFV 524

  Fly   130 AREWVPPSPPKVDWAKEIDEELERQKR-KKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTP 193
            .:.....||.            |::|| ..||.:               |:|||.:..|.  :||
  Rat   525 DKYSTLLSPS------------EQEKRIISKSCE---------------DQRLSHTRVSV--HTP 560

  Fly   194 LPAPLPKPKPNQVGGC------------SPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATN 246
            :.|........:...|            :....:.::.|.||:....:.....|.|    .|:.|
  Rat   561 VAAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSDDGRESLPS----TVSAN 621

  Fly   247 ASQDLQNESFTS--FLS----------------------AESIAGQPDKPIGSNGDAANLMGSKP 287
            :..:.:.|...|  ||.                      ||::|         :|...|...|..
  Rat   622 SLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALA---------HGADVNWANSDE 677

  Fly   288 NSLAQEEQDFFNQGSL---------GAGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGGFTG 343
            |......|.... |||         ||..|::|..|:            .|..|...:   |.||
  Rat   678 NQATPLIQAVLG-GSLVTCEFLLQNGANVNQRDVQGR------------GPLHHATVL---GHTG 726

  Fly   344 -----MAPGGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMS-----MGG 398
                 :..|...|...::.               ..|:..|..| :||.|.:...::     |..
  Rat   727 QVCLFLKRGANQHATDEEG---------------KDPLSIAVEA-ANADIVTLLRLARMNEEMRE 775

  Fly   399 SHGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPLFGAVPQQQQQHQQQLQQ 456
            |.|..|.....|....:....|.|:.|                  |::..:.||..|:
  Rat   776 SEGLYGQPGDETYQDIFRDFSQMASNN------------------PEKLNRFQQDSQK 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	51/116 (44%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	86/319 (27%)
Acap2	XP_017453554.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810