DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and SMAP1

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001037770.1	Gene:	SMAP1 / 60682	HGNCID:	19651	Length:	467	Species:	Homo sapiens

Alignment Length:	552	Identity:	183/552 - (33%)
Similarity:	251/552 - (45%)	Gaps:	143/552 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGV 65
            |::.:..::.:.:.|:.|.:|:::||:||||||.||:||||||||||:|:|:|||||||||||||
Human     1 MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGV 65

  Fly    66 HISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALENFIRAKYEHKKYLA 130
            |||||||||||.||.||:..:|.|||::||.:|||.||:.|||||||.|:|.|||.|||.|||..
Human    66 HISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYD 130

  Fly   131 REWV----------PPSP----PKVDWAKEIDE-ELERQKRKKKSTQAQATLGLAGVAGGSGDKR 180
            :..:          |..|    |.:..|  :|: :||::|.|||.                 :|:
Human   131 KNAIAITNISSSDAPLQPLVSSPSLQAA--VDKNKLEKEKEKKKE-----------------EKK 176

  Fly   181 LSGSSASALKNTPLPAPLPKPKPNQVGGCSPKTTQRVQLNSSGVSSAGES--DLLGLSSP-TKPI 242
            .........|  ||.|...:.|..|:   .||       .|:....|.|.  |||||..| ..|:
Human   177 REKEPEKPAK--PLTAEKLQKKDQQL---EPK-------KSTSPKKAAEPTVDLLGLDGPAVAPV 229

  Fly   243 VATNASQDLQNESFTSF-------LSAESI---AGQPDKPIGSNGDAANLMGSKPNSLAQEEQDF 297
            ...|.:....|:....|       |.|..:   .|.|..|.     ||.|     :::...:.|.
Human   230 TNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPA-----AATL-----STVTSGDLDL 284

  Fly   298 FNQGSLGAGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQF 362
            |.:.:.   .:|:....::||||||:|||               ||..        |||..|..|
Human   285 FTEQTT---KSEEVAKKQLSKDSILSLYG---------------TGTI--------QQQSTPGVF 323

  Fly   363 MTPPN------------SVSMYNSPVMAAPNAFSNAAISSATAM-SMGGSHGFTGAQFPSTGGSP 414
            |.|.|            .......||.|||....|....|.:.| .|...:||.|
Human   324 MGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMG---------- 378

  Fly   415 YAAAGQAAATNLMQTNQSILSGMPLFGAVPQ-----------QQQQHQQQLQQQHHPQLGGLSMN 468
                  .|.|.:|...|:::.  |..|.|.|           |.||.|..|.|.:. |:.|:|::
Human   379 ------NAQTGVMPLPQNVVG--PQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQ-QMAGMSIS 434

  Fly   469 LMQPLPSGLNIGQPPQGAGGF--AATGPTTSS 498
            ...|.   ...|||.....|:  :::|.|.|:
Human   435 SATPT---AGFGQPSSTTAGWSGSSSGQTLST 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	81/113 (72%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	123/307 (40%)
SMAP1	NP_001037770.1	ArfGap	20..120	CDD:279720	72/99 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..224		28/109 (26%)
		Interaction with clathrin heavy chains. /evidence=ECO:0000250	218..222		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..467		17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3433
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3651
Isobase	1	0.950	-	0	Normalized mean entropy	S2206
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097163at2759
OrthoFinder	1	1.000	-	-		FOG0001773
OrthoInspector	1	1.000	-	-		otm40960
orthoMCL	1	0.900	-	-		OOG6_100831
Panther	1	1.100	-	-	O	PTHR45705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1895
SonicParanoid	1	1.000	-	-		X1301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810