Protein Alignment CG8243 and acap2a

DIOPT Version :9

• Sequence 1: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_005163306.1
• Gene: acap2a / 564814
• ZFINID: ZDB-GENE-081104-34
• Length: 824
• Species: Danio rerio
• Alignment Length: 523
• Identity: 128/523 - (24%)
• Similarity: 207/523 - (39%)
• Gaps: 160/523 - (30%)

  Fly     2 SSSNAG------QRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIH 60
            ||::.|      :..||:  |.::.|.::|....|::|.||....|||||.||.:.|||.|:|||
Zfish   382 SSASLGSLDSGCESVKLV--KGESALQRVLAIPGNEFCCDCGQSDPRWASINLCITLCIECSGIH 444

  Fly    61 RNLGVHISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPD-GFRRPQTD---TALENFIRA 121
            |:||||.|:|:|:.||||.||.:..:.::||.....:|||...: |.::||..   ..:|.||||
Zfish   445 RSLGVHNSKVRSLTLDTWEPELLKLMCELGNDVINQIYEAHREENGGKKPQPGDPRREIEAFIRA 509

  Fly   122 KYEHKKYLAREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSA 186
            ||..|:::.:      |.:       .|::|:....:|.                 |||:.|:..
Zfish   510 KYVDKRFVLK------PTE-------QEQMEKIMTLRKH-----------------DKRMQGNME 544

  Fly   187 SALKNTPLPAPLPKPKPNQVGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDL 251
            .      ||   |:|.|       |....|...|:|                    ||:.:.|::
Zfish   545 F------LP---PRPPP-------PTPKLRTASNAS--------------------VASLSGQEV 573

  Fly   252 QNES----------FTSFLSAESIAG--QPDKPIGSNGDAA-NLMGSKPNSLAQEEQDFFNQGSL 303
            :.:|          |:.|.::..:..  :.|..|.::.|.: .::.|.|:|.:..|.|.   ...
Zfish   574 RRDSLFCPDELDSLFSYFDTSSKLQNLKRADSGIQNSADGSREMLASTPSSSSLSETDL---PES 635

  Fly   304 GAGGNEKDQSGKMSK------DSIL-------ALYGSAPA-THNPQMNFGGF--TGMAP------ 346
            .|..|:.::|...||      ||:|       :|...|.| .|...:|:...  :...|
Zfish   636 EAAANQAERSPVFSKLTNFSADSLLYWASCACSLKDMAQALAHGADINWVNLEDSSRTPLIQAVQ 700

  Fly   347 GGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGSHGFTG--AQFPS 409
            ||.:       |..:|:       :.|:..:...:......:..||.:      |.||  ..|..
Zfish   701 GGSL-------ISCEFL-------LQNAACVDQQDIRGRGPLHHATIL------GHTGQVCLFLK 745

  Fly   410 TGG----------SPYAAAGQAAATN------LMQTNQSILSGMPLFGAVPQQQQQHQQQLQQQH 458
            .|.          ||.:.|.:||..:      |.:.|:.:......||      |..|..|.|.|
Zfish   746 RGAKQNTVDTDSRSPLSIAVEAANADIVTLLRLAKMNEEMRGSEGAFG------QAGQYSLSQSH 804

  Fly   459 HPQ 461
            ..|
Zfish   805 TEQ 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	50/117 (43%)
		COG5347	20..300	CDD:227651	81/296 (27%)
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322
		PH_ACAP	273..369	CDD:270070
		PH	273..365	CDD:278594
		ArfGap	402..520	CDD:279720	50/123 (41%)
		ANK repeat	657..686	CDD:293786	8/28 (29%)
		ANK	658..776	CDD:238125	25/137 (18%)
		Ank_2	660..754	CDD:289560	19/113 (17%)
		ANK repeat	690..721	CDD:293786	6/44 (14%)
		ANK repeat	723..754	CDD:293786	7/36 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810