DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and APPL2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001238833.1	Gene:	APPL2 / 55198	HGNCID:	18242	Length:	670	Species:	Homo sapiens

Alignment Length:	353	Identity:	67/353 - (18%)
Similarity:	115/353 - (32%)	Gaps:	103/353 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNL---- 75
            ||.:....::|..:::.|..|.|...|:                |:|||   |.:...:||
Human   251 EKMRVSQQELLSVDESVYTPDSDVAAPQ----------------INRNL---IQKAGYLNLRNKT 296

  Fly    76 ----DTWTPEQVISLQQMGNSRAR---AVYEAQLPDGFRRPQTDTALEN--FIRAKYEHKKYLAR 131
                .||  |::....|.||...:   ||....:.|          |:|  .:....|.::|..:
Human   297 GLVTTTW--ERLYFFTQGGNLMCQPRGAVAGGLIQD----------LDNCSVMAVDCEDRRYCFQ 349

  Fly   132 EWVPPSPPKV-----------DWAKEIDEELERQ----------KRKKKSTQAQATLGLAGVAGG 175
            ...|.....:           :|...|: .:.||          ..|...|..||...:...
Human   350 ITTPNGKSGIILQAESRKENEEWICAIN-NISRQIYLTDNPEAVAIKLNQTALQAVTPITSF--- 410

  Fly   176 SGDKRLSGSSASALKNTPLPAPLPKPKPNQVGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTK 240
             |.|:.|...:..|||:.:        .|:.....||.|         .|.....:|:...:|.:
Human   411 -GKKQESSCPSQNLKNSEM--------ENENDKIVPKAT---------ASLPEAEELIAPGTPIQ 457

  Fly   241 PIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGDAANLMGSKPNSLAQEEQDFFNQGSLGA 305
            ..:...|         |.||. ::...:...|.|...|.     |.|.:.....|..|....||:
Human   458 FDIVLPA---------TEFLD-QNRGSRRTNPFGETEDE-----SFPEAEDSLLQQMFIVRFLGS 507

  Fly   306 GGNEKDQSGKMSKDSILALYGSAPATHN 333
            ...:.|.:.::..:::..:. :|.|.||
Human   508 MAVKTDSTTEVIYEAMRQVL-AARAIHN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	25/126 (20%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	58/313 (19%)
APPL2	NP_001238833.1	BAR_APPL2	20..240	CDD:153316
		BAR-PH_APPL	258..382	CDD:270067	28/155 (18%)
		PTB_APPL	488..621	CDD:269980	10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900