DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Appl2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001102211.1	Gene:	Appl2 / 362860	RGDID:	1563028	Length:	662	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	86/448 - (19%)
Similarity:	140/448 - (31%)	Gaps:	141/448 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPKVDWAK 145
            |..::.||:  ||....||.|               ||...|.:.:......:         ::|
  Rat    53 EMCLATQQL--SRQLLAYEKQ---------------NFALGKGDEEVISTLHY---------FSK 91

  Fly   146 EIDE------ELERQK-----------RKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTP 193
            .:||      ||.:|.           |:|..|:......|.|:|....|..::..|.
  Rat    92 VMDELNGLHSELAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSR------- 149

  Fly   194 LPAPLPKPKPNQVGGCSPKT--------TQRVQLNSS------------GVSSAGESDLLG---- 234
                |||.|.|:    ..||        .:|.|..||            ...:|....|:|
  Rat   150 ----LPKRKENE----RVKTDVAKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAHG 206

  Fly   235 -------------------LSSPTKPI----VATNASQDLQNESFTSFLSAESIAGQPDKPIGSN 276
                               |||.|..:    |...|..|....|....||.......||..:.:.
  Rat   207 QINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVATP 271

  Fly   277 GDAANLMGSKPNSL-----------AQEEQDFFNQG--------SLGAGGNEKDQSGKMSKDSIL 322
            ....||: .|...|           ..|...||.||        ...|||..:|    :...|::
  Rat   272 QINRNLI-QKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQD----LDNCSVM 331

  Fly   323 ALYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSVS----MYNSPVMAAPNAF 383
            |:     ...:.:..|...|.....|.:.|.:.::...:::...|::|    :.::|...|.. .
  Rat   332 AV-----DCEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAINNISRQIYLTDNPEAVAIK-L 390

  Fly   384 SNAAISSATAMSMGG--SHGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPL 439
            :..|:.:.|.::..|  ...|..:|......:.|......||.::.:|.:.|..|.|:
  Rat   391 NQTALQAVTPITSFGKKQESFYFSQNIKNSDTGYVKIVPKAAASIPETEELIAPGTPI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	11/50 (22%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	58/293 (20%)
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316	43/221 (19%)
		BAR-PH_APPL	252..376	CDD:270067	25/133 (19%)
		PTB_APPL	480..613	CDD:269980
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900