DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and agfg1a

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021337018.1	Gene:	agfg1a / 327597	ZFINID:	ZDB-GENE-030131-5808	Length:	596	Species:	Danio rerio

Alignment Length:	587	Identity:	142/587 - (24%)
Similarity:	214/587 - (36%)	Gaps:	173/587 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLG-VHISRVKSVNLDT 77
            :||...:|.:|.....|:.|.|||.:||.:|:..:|.|:|..|:||.|.|. .|  ||||:::.|
Zfish    10 EEKHLKMLREMTSLAPNRKCFDCDQRGPTYANMTVGSFVCTSCSGILRGLNPPH--RVKSISMTT 72

  Fly    78 WTPEQVISLQQMGNSRARAVY-------EAQLPDGFRRPQTDTALENFIRAKYEHKKYLAREWVP 135
            :|.:::..||:.||...:.::       ...:|| ||.||   .::.|::.|||.|::    :||
Zfish    73 FTQQEIELLQKHGNEVCKQIWLGLYDDRNLAIPD-FREPQ---KVKEFLQDKYEKKRW----YVP 129

  Fly   136 PSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLP- 199
            |...|.                           :|.|...     :||||||:..:||...||.
Zfish   130 PEQAKT---------------------------VASVHAS-----ISGSSASSTSSTPEVRPLKT 162

  Fly   200 ------------KPKPNQVGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQ 252
                        |..|:|    || ...|.||........ :.||  ||.....|.|...||...
Zfish   163 LLGESVPSLHLNKNTPSQ----SP-VVSRAQLAHQQYQDR-KFDL--LSDLGGDIFAPPHSQSTG 219

  Fly   253 NESFTSFLSAESIAGQPDKPIGSNGDAANL-------------MGSKPNSLAQEEQDFFNQGSLG 304
            |.:|.:|....|.:.|   .:.::.|.||.             ..|.|.:..|..|..:|  ||.
Zfish   220 NANFANFAHFNSHSAQ---SVNASADFANFDTFKSSAAPTTAAFPSAPQAPFQPPQPVYN--SLP 279

  Fly   305 AGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSV 369
            ...:..:.:..:..   ||::.|:....|  .||..|..      .|:......|....:..|||
Zfish   280 FSRSVGEFTSLLPP---LAMHSSSSGLSN--ANFANFDN------FHKSCSADFPSFSSSQSNSV 333

  Fly   370 -SMYNSPVMAAP-----------NAFSNAAISSATAMSMGGSHGFTGAQFPSTGGSPYAA----- 417
             .::.:..::.|           |.||:......::.......|....|....||..|||
Zfish   334 GDVHKADAVSVPADRYAALADLDNIFSSKPEQGPSSAPPSAGVGPPPPQAALLGGDRYAAFAELD 398

  Fly   418 ----------AGQAAATNLMQTNQSILSGMPLFGAVP-QQQQQHQQQLQQQHH------------ 459
                      :|..|||    |.|..:.|..  .||| .|.||....:.|...
Zfish   399 NVFGPSVPNVSGYQAAT----TAQGAVYGTS--SAVPTAQAQQGLPNIPQGFAGPSTNPFVAPGA 457

  Fly   460 -----------------PQLGGLSMNLMQPLPSGLNIGQPPQGAGGFAATGPTTSSVPSNLNQQF 507
                             |.:|..:.:::.|||..   ..|   |..||:.||.:.|:|:.    |
Zfish   458 PQAPPTNPFQANGRAAVPGMGVAAADMLGPLPGH---SYP---AAHFASFGPPSMSMPTG----F 512

  Fly   508 GN 509
            ||
Zfish   513 GN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	40/121 (33%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	84/313 (27%)
agfg1a	XP_021337018.1	ArfGap	17..134	CDD:214518	43/126 (34%)
agfg1a	XP_021337018.1	DNA_pol3_gamma3	<365..594	CDD:331207	37/166 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910