Protein Alignment CG8243 and AGFG1

DIOPT Version :9

• Sequence 1: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001128659.1
• Gene: AGFG1 / 3267
• HGNCID: 5175
• Length: 584
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 128/564 - (22%)
• Similarity: 196/564 - (34%)
• Gaps: 196/564 - (34%)

  Fly    23 QMLRD----EDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLG-VHISRVKSVNLDTWTPEQ 82
            :||||    ..|:.|.|||.:||.:.:..:|.|:|..|:|..|.|. .|  ||||:::.|:|.::
Human    15 KMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPH--RVKSISMTTFTQQE 77

  Fly    83 VISLQQMGNSRARAVY-------EAQLPDGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPK 140
            :..||:.||...:.::       .:.:|| ||.||   .::.|::.|||.|::    :|||...|
Human    78 IEFLQKHGNEVCKQIWLGLFDDRSSAIPD-FRDPQ---KVKEFLQEKYEKKRW----YVPPEQAK 134

  Fly   141 VDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQ 205
            |                           :|.|...     :||||||:..:|    |..||..:.
Human   135 V---------------------------VASVHAS-----ISGSSASSTSST----PEVKPLKSL 163

  Fly   206 VGGCSPKTTQRVQLNSSGVSSAGESDLLG--------------LSSPTKPIVATNASQDLQNESF 256
            :|..:|    .:.||.   .:..:|.::|              ||.....|.|..|.|.....:|
Human   164 LGDSAP----TLHLNK---GTPSQSPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTATANF 221

  Fly   257 TSFLSAESIAGQPDKPIGSNGDAANLMGSKPNSLAQEEQDFFNQGSLGAGGNEKDQSGKMSKDSI 321
            .:|....|.|.|.    .:|.|.||.             |.|.|.|    |:..
Human   222 ANFAHFNSHAAQN----SANADFANF-------------DAFGQSS----GSSN----------- 254

  Fly   322 LALYGSAP-ATHNP-------------QMNFGGFTGMAPGGYMHQQQQQQI-------------- 358
               :|..| |:|:|             ..:||.||...|....|......:
Human   255 ---FGGFPTASHSPFQPQTTAFRMLSSSCSFGEFTSAFPLQATHSGSAASVNANFAHFDNFPKSS 316

  Fly   359 -----------PHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGSHGFTGAQFPSTGG 412
                       .||..:..:.||...:.:..|.   ..||:::...:...|..|..|:.|.:||.
Human   317 SADFGTFNTSQSHQTASAVSKVSTNKAGLQTAD---KYAALANLDNIFSAGQGGDQGSGFGTTGK 378

  Fly   413 SP-----------------YAAAGQ------AAATNLMQTNQSILSGMPLFGAVPQQQQQHQQQL 454
            :|                 |||..:      :|||:......:..:...:||.||.......|..
Human   379 APVGSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQPA 443

  Fly   455 QQQHHPQLGGLSMNLMQPLPSGLNIGQPPQGAGGFAATGPTTSS 498
            ...             .|.|    .|..|......||.||:.:|
Human   444 SSS-------------VPAP----FGATPSTNPFVAAAGPSVAS 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	40/120 (33%)
		COG5347	20..300	CDD:227651	80/302 (26%)
AGFG1	NP_001128659.1	COG5347	8..319	CDD:227651	94/391 (24%)
		ArfGap	14..135	CDD:214518	43/129 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810