DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and acap3a

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_021325699.1	Gene:	acap3a / 322991	ZFINID:	ZDB-GENE-030131-1711	Length:	845	Species:	Danio rerio

Alignment Length:	357	Identity:	93/357 - (26%)
Similarity:	150/357 - (42%)	Gaps:	77/357 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGV 65
            :||.::...::....:.:.:|.::|....|:.|.||....|||||.|||:.|||.|:||||:|||
Zfish   386 ISSIDSASESRERSVRGENILQRILSLPGNQQCCDCAQTEPRWASINLGVLLCIECSGIHRSLGV 450

  Fly    66 HISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPD-GFRRPQTDTA---LENFIRAKYEHK 126
            |.|:|:|:.||:|.||.:..:.::|||....:||....: |.::|..:::   .|.:|:|||..|
Zfish   451 HCSKVRSLTLDSWEPELLKLMCELGNSIINHIYEGSCEEQGLKKPAPNSSRQEKEAWIKAKYVEK 515

  Fly   127 KYLAREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKN 191
            |:|                           ||..|      |...|.||...:|...|......|
Zfish   516 KFL---------------------------KKMMT------GEVVVNGGRKSERRWNSRKCRRHN 547

  Fly   192 TPLPAPLPKPKPNQ-VGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDL---- 251
            :....|....|..| .|..||.|                     |||.|..:......:.|
Zfish   548 SATTVPKTHRKYRQDPGSASPAT---------------------LSSATAALERKFRRESLFCPD 591

  Fly   252 QNESFTSFLSAESIAGQP-----DKPIGSNGDAAN---LMGSKPNSLAQEE----QDFFNQGSLG 304
            :.::..|:....|....|     |..:|.:.|.:.   :..|..:|:.:||    :|..|:..|.
Zfish   592 ELDNLFSYFDTGSGPRSPTGLSSDSGLGGSTDGSTDVLVFESVVDSVTEEECEVSEDSSNEAELE 656

  Fly   305 AGGNEKDQSGKMSKDSILALYGSAPATHNPQM 336
            ...::.:.|.::  |:...||.:..|.:.|.|
Zfish   657 PEASDPEDSREL--DAGALLYKACQARNLPVM 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	49/117 (42%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	82/300 (27%)
acap3a	XP_021325699.1	BAR	16..215	CDD:325158
		PH_ACAP	271..367	CDD:270070
		ArfGap	403..520	CDD:307528	49/143 (34%)
		ANK	674..790	CDD:238125	5/13 (38%)
		ANK repeat	674..700	CDD:293786	5/13 (38%)
		ANK repeat	702..735	CDD:293786
		ANK repeat	737..762	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810