DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Agfg2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006249202.1	Gene:	Agfg2 / 304375	RGDID:	1306590	Length:	488	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	128/549 - (23%)
Similarity:	194/549 - (35%)	Gaps:	197/549 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLG-VHISRVKSVNLDTWTPEQVISLQQMGNSR 93
            |::|.:|..:|..:....:|.|:|..|:|:.|.|. .|  ||||:::.|:|..:|:.||..||..
  Rat    44 NRHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPH--RVKSISMTTFTEPEVLFLQSRGNEV 106

  Fly    94 ARAV----YEAQ---LPDGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPKVDWAKEIDEEL 151
            .|.:    ::|:   :||. |.||   .::.|::.|||.|::    :|||..
  Rat   107 CRKIWLGLFDARTSLVPDS-RDPQ---KVKEFLQEKYEKKRW----YVPPEQ------------- 150

  Fly   152 ERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQVGGCSPKTTQR 216
                                |.|.|..|    .|.||   ||:...:|:.||.:.
  Rat   151 --------------------VKGASYSK----GSVSA---TPVQGSVPEGKPIRT---------- 178

  Fly   217 VQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGDAAN 281
                           |||...|:....|:.:||.:..                     |....|.
  Rat   179 ---------------LLGDPVPSLSDAASTSSQSVSQ---------------------SQARTAQ 207

  Fly   282 LMGSKPNSLAQEEQDFFNQGSLGAGGNEKDQSGKMSKDSILALYGSAPATHNPQM-----NFGGF 341
            ...|:|.|                     ..|.|.:...:||..|..|.. .||:     :|.||
  Rat   208 ARSSQPPS---------------------HSSTKKASTDLLADIGGDPFA-APQVAPAFASFPGF 250

  Fly   342 TGMAP--GGYMHQQQQQQIPHQ--FMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGSHGF 402
            .|..|  ||:.:.......|..  |.:.|.||   .:|..|.|...:|..::        ||:.|
  Rat   251 GGQNPSHGGFANFDAFSSSPSSSAFGSLPPSV---QTPFQAQPTPAANRMLT--------GSYSF 304

  Fly   403 TGAQFPSTGGSPYAAAGQ----AAATNLMQTNQSILSGMP--LFGAVPQQQQQHQQQLQQQHHPQ 461
            ..:|..:.|.:|.|||.|    |....|::...: ..|:|  :|| :|.|....|..:     |.
  Rat   305 GSSQMSAFGVAPLAAASQPNSLADVGGLLEPRMA-AGGLPGSVFG-MPSQVPALQSAV-----PG 362

  Fly   462 LGGL---------------------SMNLMQP--LPSGLNIG---------QPPQGAGGFAAT-- 492
            :||.                     |.|..||  :.||...|         ||...:|.||:|
  Rat   363 VGGSTGLPFGAFTNPFTTPAQPQLPSTNPFQPNGIASGPGYGMGSVQPGLLQPAPPSGAFASTFP 427

  Fly   493 ---GPTTSSVPSNLN-QQFGNLNIGNVWQ 517
               .||.:.:....| ..||:|....:.|
  Rat   428 APVFPTQAGLVEQQNGSSFGDLGTSKLGQ 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	35/109 (32%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	62/277 (22%)
Agfg2	XP_006249202.1	ArfGap	40..152	CDD:295313	38/150 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900