DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Smap2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001094139.1	Gene:	Smap2 / 298500	RGDID:	1308418	Length:	428	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	174/496 - (35%)
Similarity:	241/496 - (48%)	Gaps:	106/496 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWT 79
            ::.|.:|..:|.:||||:|.||.:|||||||||:|:|:||||||||||||||||||||||||.||
  Rat    10 DRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWT 74

  Fly    80 PEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPKVDWA 144
            .||:..:|:|||.:|..:|||.||:.|||||.|.|:|.|||.|||.|||:.|
  Rat    75 QEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMDR------------- 126

  Fly   145 KEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKP---NQV 206
             .:|..:.|:::                    .||...||.         |||..|.:|   .:|
  Rat   127 -SLDINVLRKEK--------------------DDKWKRGSE---------PAPEKKMEPVVFEKV 161

  Fly   207 GGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDK 271
            .....|...::...||..|:|...|||||.:|....:|.:.:.:...:......|..|.:....|
  Rat   162 KMPQKKEDAQLPRKSSPKSAAPVMDLLGLDAPVACSIANSKTSNALEKDLDLLASVPSPSSVSRK 226

  Fly   272 PIGSNGDAANLMGSKPNSLAQEEQDFFNQGSLGAGGNEKDQSGK--MSKDSILALYGSAPATHNP 334
            .:||...|.: .||.|.:|     :.|.:     .|::.:::||  :||||||:||||    ..|
  Rat   227 AVGSMPTAGS-AGSVPENL-----NLFPE-----PGSKSEETGKKQLSKDSILSLYGS----QTP 276

  Fly   335 QMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSV--SMYNSPV--MAAPNAFSNAAISSATAMS 395
            ||...... |||....:.......|.  :|||||:  ||...||  :|.|     .|....|.|:
  Rat   277 QMPAQAMF-MAPAQMAYPTAYPSFPG--VTPPNSIMGSMMPPPVGMVAHP-----GASGMVTPMA 333

  Fly   396 MGGSHGFTGAQFPSTGGSPYAAAGQAAATNLMQTNQ----SILSGMP--LFGAVPQQQ-QQHQQQ 453
            |..  |:.|....|..|.|         :.:|.|.|    :.::.||  ::|..|.|| |.:..|
  Rat   334 MPA--GYMGGMQASMAGVP---------SGMMTTQQAGYMASMAAMPQTVYGVQPAQQLQWNLTQ 387

  Fly   454 LQQQHHPQLGGLSM---NLMQPLPSGLNIGQPPQGAGGFAA 491
            :.|    |:.|::.   |.|      ::.||...|..|.||
  Rat   388 MTQ----QMAGMNFYGANGM------MSYGQSMGGGNGQAA 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	76/113 (67%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	111/282 (39%)
Smap2	NP_001094139.1	ArfGap_SMAP2	16..122	CDD:350083	72/105 (69%)
Smap2	NP_001094139.1	PBP1	<102..419	CDD:227507	114/404 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351293
Domainoid	1	1.000	186	1.000	Domainoid score	I3265
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41489
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3534
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097163at2759
OrthoFinder	1	1.000	-	-		FOG0001773
OrthoInspector	1	1.000	-	-		otm45094
orthoMCL	1	0.900	-	-		OOG6_100831
Panther	1	1.100	-	-	LDO	PTHR45705
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760