Protein Alignment CG8243 and Git2

DIOPT Version :9

• Sequence 1: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_006530402.1
• Gene: Git2 / 26431
• MGIID: 1347053
• Length: 761
• Species: Mus musculus
• Alignment Length: 633
• Identity: 129/633 - (20%)
• Similarity: 212/633 - (33%)
• Gaps: 221/633 - (34%)

  Fly    21 LTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWTPEQVIS 85
            :::.||..|  .|.||:...|.|||.|.|.|:|..|..:||:||.|||:|:.:....|.|..:..
Mouse     1 MSKRLRSSD--VCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQM 63

  Fly    86 LQQMGNSRARAVYEAQLPD------GFRR--PQTDTALEN---FIRAKYEHKKYLAREWVPPSPP 139
            ::.:.|:.|.:::|..|.|      |.|:  || |....|   ||||||:...::.|  :|....
Mouse    64 VETLYNNGANSIWEHSLLDPASIMSGRRKANPQ-DKVHPNKAEFIRAKYQMLAFVHR--LPCRED 125

  Fly   140 KVDWAKEIDEELERQKR--------KKKSTQAQAT----------LGLAGVAGGSGDKRL----- 181
            ....||::.::|....|        :..|..|||.          |.:|..||......|
Mouse   126 DSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYG 190

  Fly   182 --SGSSASALKNTP--------------------------LPAPLPKPKPNQVGG----CSPKTT 214
              .|:..|:.| ||                          |...|...||:...|    ...:..
Mouse   191 ADPGTQDSSGK-TPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRAD 254

  Fly   215 QRVQLNSSGVSSAGESDLLGLSS------------------------------------------ 237
            :|:.|:.|.::.|.:..|..||:
Mouse   255 RRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFL 319

  Fly   238 PTKPIVATNASQDLQN------ESFTSF---LSAESIAGQPDKPIGSNGDAANLM---GSKPNSL 290
            |..|..::..:|..|.      ..|.:.   :.:::...|...|:..:.|...|:   .|..:|.
Mouse   320 PVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHST 384

  Fly   291 AQEEQDFFNQGSLGAGGNEKDQSGKMSK-------DSILALYGSAPATHNPQMNFGGFTGMAPGG 348
            ..::.|..:..|: |...:.|...:.||       ||.|:   ..|.|....|.       ....
Mouse   385 ESQDNDQPDYDSV-ASDEDTDVETRASKANRQKSLDSDLS---DGPVTVQEFME-------VKSA 438

  Fly   349 YMHQQQQQQIPHQFMTPPNSVS-----MYN--SPVMAAPNAFSNAAISSATAMSMGGSHGFTGA- 405
            .:..:.::|   |.|...|::|     |..  ..:.:..::....|.:||..:..|..|..|.:
Mouse   439 LVASEAKRQ---QLMKVNNNLSDELRIMQKKLQTLQSENSSLRRQATASACQVQTGSDHKDTASH 500

  Fly   406 ----QFPSTGGS-------------PYAAAGQAAATNLMQTNQSILSGMPLFGAVPQQQQQHQQQ 453
                :.||..||             ||...|:|:
Mouse   501 SSLKRRPSARGSRPMSMYETGSGQKPYLPMGEAS------------------------------- 534

  Fly   454 LQQQHHPQLGGLSMNLMQPLPSGLNIGQPPQGAGGFAATGPTTSSVPS 501
                 ||:   .|...:||.|:.:          |.:|...::||:||
Mouse   535 -----HPE---ESRTRLQPFPTHI----------GRSALVTSSSSLPS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	42/121 (35%)
		COG5347	20..300	CDD:227651	86/398 (22%)
Git2	XP_006530402.1	ArfGap_GIT2	1..111	CDD:350072	40/112 (36%)
		Ank_2	137..229	CDD:372319	16/92 (17%)
		ANK repeat	137..165	CDD:293786	6/27 (22%)
		ANK repeat	167..197	CDD:293786	6/29 (21%)
		GIT_SHD	268..296	CDD:369921	3/27 (11%)
		GIT_SHD	332..360	CDD:369921	2/27 (7%)
		GIT_CC	416..480	CDD:374629	12/76 (16%)
		GIT1_C	640..754	CDD:371961

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810