DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and ACAP2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_016861535.1	Gene:	ACAP2 / 23527	HGNCID:	16469	Length:	848	Species:	Homo sapiens

Alignment Length:	506	Identity:	122/506 - (24%)
Similarity:	195/506 - (38%)	Gaps:	129/506 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHI 67
            |.::|..:|....|.::.|.::.....|..|.||....|||||.|||:.|||.|:||||:||||.
Human   419 SLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 483

  Fly    68 SRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPD-GFRRPQTDTALEN--FIRAKYEHKKYL 129
            |:|:|:.||||.||.:..:.::||.....||||.:.. |.::||.....|.  :|||||..:|::
Human   484 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFV 548

  Fly   130 AREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDK-RLSGSSASALKNTP 193
            .:..:..|||            |:||:....:..:..|.::..  |.||: |.|..|:....|:.
Human   549 DKYSISLSPP------------EQQKKFVSKSSEEKRLSISKF--GPGDQVRASAQSSVIAVNSD 599

  Fly   194 LPAPLPKPKPNQVGGC-----SPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQN 253
            .........|:::...     :....:.::.|.||:..:.:.....|.|    .|:.|:..:.:.
Human   600 EARRESLFCPDELDSLFSYFDTSSKLRSIRSNDSGIQQSSDDGRESLPS----TVSANSLYEPEG 660

  Fly   254 ESFTS--FLS----------------------AESIAGQPDKPIGSNGDAANLMGSKPNSLAQEE 294
            |...|  ||.                      ||::|.      |::.:.||...:|...|.|..
Human   661 ERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAH------GADVNWANSEENKATPLIQAV 719

  Fly   295 QDFFNQGSL---------GAGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGGFTG-----MA 345
            ..    |||         ||..|::|..|:            .|..|...:   |.||     :.
Human   720 LG----GSLVTCEFLLQNGANVNQRDVQGR------------GPLHHATVL---GHTGQVCLFLK 765

  Fly   346 PGGYMHQQQQQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMS-----MGGSHGFTGA 405
            .|...|...::.               ..|:..|..| :||.|.:...::     |..|.|..|.
Human   766 RGANQHATDEEG---------------KDPLSIAVEA-ANADIVTLLRLARMNEEMRESEGLYGQ 814

  Fly   406 QFPSTGGSPYAAAGQAAATNLMQTNQSILSGMPLFGAVPQQQQQHQQQLQQ 456
            ....|....:....|.|:.|                  |::..:.||..|:
Human   815 PGDETYQDIFRDFSQMASNN------------------PEKLNRFQQDSQK 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	50/116 (43%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	85/312 (27%)
ACAP2	XP_016861535.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810