DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8243 and Git1

DIOPT Version :9

Sequence 1:NP_610424.1 Gene:CG8243 / 35890 FlyBaseID:FBgn0033349 Length:517 Species:Drosophila melanogaster
Sequence 2:NP_001004144.1 Gene:Git1 / 216963 MGIID:1927140 Length:770 Species:Mus musculus


Alignment Length:656 Identity:127/656 - (19%)
Similarity:203/656 - (30%) Gaps:229/656 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 CVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWTPEQVISLQQMGNSRARAV 97
            |.||.|..|.|||.:.|:.:|..|..:||:||.|||.||.:....|.|..:..:..:.::.|.::
Mouse    11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSI 75

  Fly    98 YE------AQLPDGFRR--PQ--TDTALENFIRAKYEHKKYLAREWVPPSPPKVDWAKEIDEELE 152
            :|      ||:..|.|:  ||  .......||||||:...::.:  :|........||::.::|.
Mouse    76 WEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK--LPCRDDDGVTAKDLSKQLH 138

  Fly   153 RQKR--------KKKSTQAQAT----------LGLAGVAG---------------GSGD------ 178
            ...|        :..|..|||.          |.:|..||               ||.|      
Mouse   139 SSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTP 203

  Fly   179 ---KRLSGSSASALK--------NTPLPAPLPKPKPNQVGG--CSPKTTQRVQ-------LNSSG 223
               .|.:|....|.:        ...|...|...||:...|  ..|:...|.:       |:.|.
Mouse   204 IDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSE 268

  Fly   224 VSSAGESDLLGLSS------------------------------------------PTKPIVATN 246
            ::.|.:..|..||:                                          |..|..:..
Mouse   269 LAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSAT 333

  Fly   247 ASQDLQN------ESFTSF---LSAESIAGQPDKPIGSNGDAANLMGSKPNSL----------AQ 292
            .:|..|.      ..|.:.   :.:|:...|..|.:.|..|...|.....:.|          :.
Mouse   334 RNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARSQSELDDQHDYDSVASD 398

  Fly   293 EEQDFFNQGSLGAGGNEKDQS--------GKMSKDSILALY------------------------ 325
            |:.|.....|.||..|.:.:|        |.::....|.|.                        
Mouse   399 EDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDEL 463

  Fly   326 ---------------------GSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSV 369
                                 |..|....|... ...|.|.|||..|::.:|           :.
Mouse   464 RRLQREIHKLQAENLQLRQPPGPVPPPSLPSER-AEHTLMGPGGSTHRRDRQ-----------AF 516

  Fly   370 SMYN-----SPVMAAP--------NAFSNAAISSATAMSM---GGSH----GFTGAQFPSTGGSP 414
            |||.     .|....|        ..|.:..:......|:   .|.:    |.:.:..|.|..||
Mouse   517 SMYEPGSALKPFGGTPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASSVPFTPSSP 581

  Fly   415 YAAAGQAAATNLMQTN----------QSILSGMPLFGAVPQQQQQHQQQLQQQHHPQLGGLSMNL 469
            ..:..|..:.:..:.:          ::..||.||.|.  :.::..:...:.:.||:|..|..:|
Mouse   582 LLSCSQEGSRHASKLSRHGSGADSDYENTQSGDPLLGL--EGKRFLELSKEDELHPELESLDGDL 644

  Fly   470 MQPLPS 475
            ...|||
Mouse   645 DPGLPS 650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8243NP_610424.1 ArfGap 18..132 CDD:279720 36/108 (33%)
COG5347 20..300 CDD:227651 82/396 (21%)
Git1NP_001004144.1 Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 1..124 37/114 (32%)
ArfGap_GIT1 1..111 CDD:350071 34/99 (34%)
ANK 1 132..161 6/28 (21%)
Ank_2 137..229 CDD:372319 16/91 (18%)
ANK repeat 137..165 CDD:293786 6/27 (22%)
ANK 2 166..195 4/28 (14%)
ANK repeat 167..197 CDD:293786 6/29 (21%)
ANK 3 199..228 3/28 (11%)
Interaction with PCLO. /evidence=ECO:0000250|UniProtKB:Q9Z272 245..374 17/128 (13%)
Interaction with PTK2/FAK1. /evidence=ECO:0000250|UniProtKB:Q9Z272 253..424 26/170 (15%)
Interaction with ARHGEF7. /evidence=ECO:0000250|UniProtKB:Q9Z272 254..376 17/121 (14%)
GIT_SHD <281..301 CDD:369921 1/19 (5%)
GIT_SHD 337..365 CDD:369921 3/27 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..425 13/61 (21%)
Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250|UniProtKB:Q9Z272 375..596 36/232 (16%)
Required for localization at synapses. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 375..596 36/232 (16%)
GIT_CC 418..482 CDD:374629 4/63 (6%)
Interaction with MAPK1. /evidence=ECO:0000269|PubMed:15923189 420..475 3/54 (6%)
Interaction with IKBKG. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 429..629 31/213 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..615 5/36 (14%)
Interaction with PXN and TGFB1I1. /evidence=ECO:0000250|UniProtKB:Q9Z272 646..770 3/5 (60%)
GIT1_C 649..763 CDD:371961 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.