DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Acap1

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_722483.2	Gene:	Acap1 / 216859	MGIID:	2388270	Length:	740	Species:	Mus musculus

Alignment Length:	330	Identity:	86/330 - (26%)
Similarity:	129/330 - (39%)	Gaps:	100/330 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSVNLDTWTPEQVISLQQMGNS 92
            :.|..|.||....|.|||.|||:.|||:|:||||:||||.|:|:|:.||:|.||.|..:.::||.
Mouse   415 DGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479

  Fly    93 RARAVYEAQL---------PDGFRRPQTDTALENFIRAKYEHKKYLAREWVPPSPPKVDWAKEID 148
            ....:|||::         |...|:.:     |.:|.|||..||:|.:  :|.
Mouse   480 IINQIYEARVEAMAVKKPGPSCSRQEK-----EAWIHAKYVEKKFLTK--LPE------------ 525

  Fly   149 EELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQVGGCSPKT 213
                                :.|..||.|..|         .:.|:| |.|..:|:     |...
Mouse   526 --------------------IRGRRGGRGPPR---------GHPPVP-PKPPIRPH-----SGIV 555

  Fly   214 TQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPD---KPIGS 275
            ..:.:..|..:.|.....||..::...|.:.|               .|:::|...|   ..:|.
Mouse   556 RSKSECPSDDMGSLHPGALLFQAAGHPPSLPT---------------MADALAHGADVNWVNVGQ 605

  Fly   276 NGDAANLMGSKPNSLAQEEQDFFNQGSLGAGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGG 340
            ......:..:..|||...|  |..|.  ||..|:.|.:|:            .|..|...:   |
Mouse   606 GNATPLIRATAANSLLACE--FLLQN--GANVNQADSAGR------------GPLHHATIL---G 651

  Fly   341 FTGMA 345
            .||:|
Mouse   652 HTGLA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	47/112 (42%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	74/283 (26%)
Acap1	NP_722483.2	Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250\|UniProtKB:Q15027	1..382
		BAR_ACAP1	18..217	CDD:153323
		PH	266..360	CDD:278594
		PH_ACAP	268..364	CDD:270070
		Required for interaction with GULP1. /evidence=ECO:0000250\|UniProtKB:Q15027	405..740		86/330 (26%)
		ArfGap	406..519	CDD:279720	45/108 (42%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250	525..566		12/87 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..562		11/83 (13%)
		Ank_2	575..670	CDD:289560	24/116 (21%)
		ANK repeat	575..602	CDD:293786	6/41 (15%)
		ANK	<592..692	CDD:238125	20/84 (24%)
		ANK repeat	606..637	CDD:293786	9/34 (26%)
		ANK repeat	639..670	CDD:293786	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810