DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and AGAP3

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_114152.3	Gene:	AGAP3 / 116988	HGNCID:	16923	Length:	911	Species:	Homo sapiens

Alignment Length:	205	Identity:	71/205 - (34%)
Similarity:	104/205 - (50%)	Gaps:	37/205 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NAGQRTKLIQEKCQTLLTQMLRD-EDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHIS 68
            :|..:|:|..:.. .|..|.:|. ..|.:|:||||..|.|||.|||..:||.|:||||:||.|:|
Human   649 SAKDKTRLGNQNA-ALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLS 712

  Fly    69 RVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTA---LENFIRAKYEHKKYLA 130
            ||:|::||.|.||.:..:..|||:.|.:|:|..| .|:.:|..|..   .|.:||||||.|.:||
Human   713 RVRSLDLDDWPPELLAVMTAMGNALANSVWEGAL-GGYSKPGPDACREEKERWIRAKYEQKLFLA 776

  Fly   131 REWVPPSPPK-VDWAKE-----IDEEL--------ERQKRKKKSTQAQATLGLAGVAGGSGDKRL 181
                 |.|.. |...::     ::::|        ...|.:...|.            |.||.|.
Human   777 -----PLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETY------------GDGDGRT 824

  Fly   182 SGSSASALKN 191
            :...:||:.|
Human   825 ALHLSSAMAN 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	55/117 (47%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	68/190 (36%)
AGAP3	NP_114152.3	small_GTPase	126..291	CDD:197466
		Centaurin_gamma	128..285	CDD:133303
		PH_AGAP	401..645	CDD:241281
		PH	404..>465	CDD:278594
		ArfGap	664..778	CDD:279720	54/119 (45%)
		Ank_2	789..879	CDD:289560	10/58 (17%)
		ANK	789..>878	CDD:238125	10/58 (17%)
		ANK repeat	789..819	CDD:293786	3/41 (7%)
		ANK repeat	821..852	CDD:293786	5/14 (36%)
		ANK repeat	854..879	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810