DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and AGAP2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001116244.1	Gene:	AGAP2 / 116986	HGNCID:	16921	Length:	1192	Species:	Homo sapiens

Alignment Length:	202	Identity:	73/202 - (36%)
Similarity:	102/202 - (50%)	Gaps:	30/202 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSNAGQRTKLIQEKCQTLLTQMLRD-EDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVH 66
            ||....||   ..:.:.:..|.:|: :.|..||||.|..|.|||.|||..:||.|:|||||||.|
Human   918 SSKVKLRT---DSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTH 979

  Fly    67 ISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTA---LENFIRAKYEHKKY 128
            :|||:|::||.|..|..:.|..:||..|..|:|:. ..|..:|..|::   .|::||||||...:
Human   980 LSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD-TRGRAKPSRDSSREERESWIRAKYEQLLF 1043

  Fly   129 LAREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQAT--LGLAGVAGGSGDKRLSGSSASALKN 191
            ||    |.|..        :|.|.||.......|..||  |.||....|..|        :::::
Human  1044 LA----PLSTS--------EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLD--------TSVED 1088

  Fly   192 TPLPAPL 198
            ..|.:||
Human  1089 PQLRSPL 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	52/117 (44%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	69/185 (37%)
AGAP2	NP_001116244.1	Interaction with EPB41L1. /evidence=ECO:0000250	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..377
		Interactions with HOMER1 and NF2. /evidence=ECO:0000250	180..225
		Interaction with PLCG1. /evidence=ECO:0000250	267..390
		G domain	405..572
		small_GTPase	405..572	CDD:197466
		Centaurin_gamma	407..566	CDD:133303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..619
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..673
		PH_AGAP	674..914	CDD:241281
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..854
		PH	<845..909	CDD:278594
		ArfGap	933..1047	CDD:279720	52/118 (44%)
		Ank_2	1058..1148	CDD:289560	11/46 (24%)
		ANK	1058..>1147	CDD:238125	11/46 (24%)
		ANK repeat	1058..1088	CDD:293786	8/37 (22%)
		ANK repeat	1090..1121	CDD:293786	3/6 (50%)
		ANK 1	1090..1119		3/6 (50%)
		ANK 2	1123..1152
		ANK repeat	1123..1148	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810