DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8243 and ARAP2

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_056045.2	Gene:	ARAP2 / 116984	HGNCID:	16924	Length:	1704	Species:	Homo sapiens

Alignment Length:	344	Identity:	87/344 - (25%)
Similarity:	128/344 - (37%)	Gaps:	102/344 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKCQTLLTQMLRD----------EDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISR 69
            |..|..:.:.|.|          |.|:.|.||.|..|.|||.||.:.:|.:|||.||:||...|:
Human   672 EAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSK 736

  Fly    70 VKSVNLDT--WTPEQVISLQQMGNSRARAVYEAQLPDGFRRPQTDTAL---------ENFIRAKY 123
            |:|:.:|.  |:.|.:.....:||.||...:...|       |.|..|         :|||..||
Human   737 VRSLKMDASIWSNELIELFIVIGNKRANDFWAGNL-------QKDEELHMDSPVEKRKNFITQKY 794

  Fly   124 EHKKYLAREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASA 188
            :..|:  |:.:..|..|    :|:::.|.....|....:..|.|             .||:....
Human   795 KEGKF--RKTLLASLTK----EELNKALCAAVVKPDVLETMALL-------------FSGADVMC 840

  Fly   189 LKNTPL---PAPLPKPKPNQVGGCSPKTTQRVQ----------------LNSSGVSSAGES---- 230
            ....|:   |..|.|           |..|.:|                ::|.||.|...|
Human   841 ATGDPVHSTPYLLAK-----------KAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTF 894

  Fly   231 --DLL--------GLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGDAANLMGS 285
              |.|        .|||..|.:..||....:....|.|:.       :.||....|| ..|:  :
Human   895 LCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYY-------ENDKSTTPNG-TINI--N 949

  Fly   286 KPNSLAQEEQDFF-NQGSL 303
            :...||..::||: |.|.:
Human   950 EVICLAIHKEDFYLNTGPI 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	43/134 (32%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	83/334 (25%)
ARAP2	NP_056045.2	SAM_Arap1,2,3	6..68	CDD:188889
		SAM	13..65	CDD:197735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..161
		PH1_ARAP	484..576	CDD:270073
		PH	484..574	CDD:278594
		PH	588..679	CDD:278594	2/6 (33%)
		PH2_ARAP	588..675	CDD:270074	1/2 (50%)
		ArfGap	686..801	CDD:279720	40/123 (33%)
		PH3_ARAP	892..1002	CDD:270076	21/87 (24%)
		PH	921..998	CDD:278594	13/58 (22%)
		PH4_ARAP	1015..1110	CDD:270077
		RhoGAP_ARAP	1114..1293	CDD:239850
		UBQ	1330..1417	CDD:294102
		PH5_ARAP	1423..1543	CDD:270079
		PH	1436..1537	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1675
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900