Protein Alignment CG8243 and ACAP3

DIOPT Version :9

• Sequence 1: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_011538908.1
• Gene: ACAP3 / 116983
• HGNCID: 16754
• Length: 844
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 124/536 - (23%)
• Similarity: 183/536 - (34%)
• Gaps: 196/536 - (36%)

  Fly     2 SSSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVH 66
            ||.::...|:....|.:::|.::.....|..|.||....|||||.|||:.|||.|:||||:||||
Human   397 SSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVH 461

  Fly    67 ISRVKSVNLDTWTPEQVISLQQMGNSRARAVYEAQLPD-GFRRPQTDTA---LENFIRAKYEHKK 127
            .|:|:|:.||:|.||.:..:.::|||....:||||... |.|:|...::   .|.:|:.||..||
Human   462 CSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKK 526

  Fly   128 YL-----------AREW------VPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGV--- 172
            :|           .|.|      .|.|.|:...|:       |:.|.:......|.|...|.
Human   527 FLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTAR-------RKVRLEPVLPCVAALSSVGTLDR 584

  Fly   173 -----------------------AGGSGDKRLSGSSASALKNTPLPAPLPKPKPNQVGGCSPKTT 214
                                   |.|:|.:.||..|.                   :||
Human   585 KFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSG-------------------LGG------ 624

  Fly   215 QRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESFTSFLSAESIAGQPDKPIGSNGD- 278
                      ||.|.||:|...|.:   |..:.:::...||       |..:|:.|      ||
Human   625 ----------SSDGSSDVLAFGSGS---VVDSVTEEEGAES-------EESSGEAD------GDT 663

  Fly   279 --------------------------------AANLMGSKPNSLAQEEQ---------------- 295
                                            ||...|::.|....|::
Human   664 EAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIV 728

  Fly   296 -DFFNQGSLGAGGNEKDQSGKMSKDSILALYGSAPATHNPQMNFGGFTG-----MAPGGYMHQQQ 354
             :|..|.  ||..|::|..|:            ||..|...:   |.||     :..|...|...
Human   729 CEFLLQN--GADVNQRDSRGR------------APLHHATLL---GRTGQVCLFLKRGADQHALD 776

  Fly   355 QQQIPHQFMTPPNSVSMYNSPVMAAPNAFSNAAISSATAMSMGGSHGFTGAQFPSTGGSPYAAAG 419
            |:|               ..|:..|..| :||.|.:...::............|   |.|.|.||
Human   777 QEQ---------------RDPLAIAVQA-ANADIVTLLRLARMAEEMREAEAAP---GPPGALAG 822

  Fly   420 QAAATNLMQTNQSILS 435
            ........:..|..:|
Human   823 SPTELQFRRCIQEFIS 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	50/128 (39%)
		COG5347	20..300	CDD:227651	90/376 (24%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:299863
		PH	279..373	CDD:278594
		PH_ACAP	281..377	CDD:270070
		ArfGap	413..531	CDD:279720	50/117 (43%)
		ANK	711..>798	CDD:238125	23/119 (19%)
		ANK repeat	712..743	CDD:293786	5/32 (16%)
		Ank_4	715..766	CDD:290365	13/67 (19%)
		ANK repeat	745..776	CDD:293786	9/45 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810