DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8243 and Arap3

DIOPT Version :9

Sequence 1:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	XP_006525549.1	Gene:	Arap3 / 106952	MGIID:	2147274	Length:	1539	Species:	Mus musculus

Alignment Length:	265	Identity:	77/265 - (29%)
Similarity:	108/265 - (40%)	Gaps:	32/265 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QTLLTQMLRDED----------NKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKS 72
            |..:|:.|.|.:          |::|.||.|..|.||:.|||:.:|.:|||.||.||..||:|:|
Mouse   475 QEAVTETLSDYEVAEKVWSNPANRHCADCRASRPDWAAVNLGVVICKQCAGQHRALGSGISKVQS 539

  Fly    73 VNLDT--WTPEQVISLQQMGNSRARAVYEAQLP--DGFRRPQTDTALENFIRAKYEHKKYLAREW 133
            :.|||  |:.|.|.....:||.||...:...||  :|............||..||  |..|.|:.
Mouse   540 LKLDTSVWSNEIVQLFIVLGNDRANCFWAGALPPGEGLHPDSAPGPRGEFISRKY--KLGLFRKP 602

  Fly   134 VPPSPPKVDWAKEIDEELERQKRKKKSTQAQATLGLAGVAGGSGDKRLSGSSASALKNTPLPAPL 198
            .|..|......:.:...:......|...|      |..|....|::.||.|:.    |..|.:.|
Mouse   603 HPRHPDHSQLLQALCAAMAGPNLLKNMAQ------LLCVETSEGEEPLSPSAL----NGSLLSLL 657

  Fly   199 PKPKPNQVGGCSPKTTQRVQLNSSGVSS-AGESDL-LGLSSPTKPIVATNASQDLQNESFTSFLS 261
            |...|..........|.|..|....:|: ||...| .|..:|.:......|:.    |.|.|..|
Mouse   658 PSDSPGVYNEVVVPATYRGFLYCGSISNKAGAPPLRRGRDAPPRLWCVLGAAL----EMFASESS 718

  Fly   262 AESIA 266
            .|.::
Mouse   719 PEPLS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	46/127 (36%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	76/263 (29%)
Arap3	XP_006525549.1	SAM_Arap1,2,3	4..66	CDD:188889
		PHA03247	<81..312	CDD:223021
		PH1_ARAP	285..377	CDD:270073
		PH2_ARAP	392..475	CDD:270074	77/265 (29%)
		ArfGap_ARAP3	485..600	CDD:350089	42/116 (36%)
		PH-like	671..783	CDD:388408	15/57 (26%)
		PH-like	798..891	CDD:388408
		RhoGAP_ARAP	906..1081	CDD:239850
		Ubiquitin_like_fold	1113..1210	CDD:391949
		PH5_ARAP	1210..1326	CDD:270079
		PLN02983	<1472..>1538	CDD:215533
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900